[1]王婷 刘维海 张盼 王钰莹 邹俊波 马战平 刘继平 王斌 王川.基于网络药理学和分子对接探讨中研益肺解毒汤防治新型冠状病毒肺炎(COVID-19)的活性成分及靶点[J].陕西中医药大学学报,2023,(02):001-8.[doi:10.13424/j.cnki.jsctcm.2023.02.001 ]
 WANG Ting LIU Weihai ZHANG Pan WANG Yuying ZOU Junbo MA Zhanping LIU Jiping WANG Bin WANG Chuan.Discussion of Active Components and Targets of Zhongyan Yifei Jiedu Decoction in Prevention and Treatment of COVID-19 Based on Network Pharmacology and Molecular Docking[J].Journal of Shaanxi University of Traditional Chinese Medicine,2023,(02):001-8.[doi:10.13424/j.cnki.jsctcm.2023.02.001 ]
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基于网络药理学和分子对接探讨中研益肺解毒汤防治新型冠状病毒肺炎(COVID-19)的活性成分及靶点
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2023年02期
页码:
001-8
栏目:
疫病防治
出版日期:
2023-05-13

文章信息/Info

Title:
Discussion of Active Components and Targets of Zhongyan Yifei Jiedu Decoction in Prevention and Treatment of COVID-19 Based on Network Pharmacology and Molecular Docking
文章编号:
2096-1340(2023)02-0001-08
作者:
王婷 1 刘维海 2 张盼 1 王钰莹 1 邹俊波 1 马战平 3 刘继平 1 王斌 1 王川 1
1.陕西中医药大学,陕西 咸阳 712046;
2.陕西中医药大学附属医院,陕西 咸阳 712000;
3.陕西省中医医院,陕西 西安 710003
Author(s):
WANG Ting 1 LIU Weihai 2 ZHANG Pan 1 WANG Yuying1 ZOU Junbo1 MA Zhanping3 LIU Jiping 1 WANG Bin1 WANG Chuan1
1.Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;
2 Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China;
3.Shaanxi Provincial Hospital of Chinese Medicine,Xian 710003,China
关键词:
关键词:中研益肺解毒汤网络药理学COVID-19中药分子对接
Keywords:
Key words: Zhongyan Yifei Jiedu DecoctionNetwork pharmacologyCOVID-19Chinese herbalMolecular docking
分类号:
R254.2
DOI:
10.13424/j.cnki.jsctcm.2023.02.001
文献标志码:
A
摘要:
摘 要:目的 基于网络药理学和分子对接探讨中研益肺解毒汤防治新型冠状病毒肺炎(COVID-19)的成分和作用机制。方法 TCMSP数据库检索中研益肺解毒汤的主要成分和作用靶点;Cytoscape构建药物-活性成分-靶点网络图;对中研益肺解毒汤与COVID-19相同靶蛋白进行GO功能富集分析和KEGG通路富集分析;分子对接研究其结合活性。结果 从中研益肺解毒汤共筛选出176个潜在活性成分和280相应靶点,69个靶点与疾病密切相关;靶点通路富集分析显示中研益肺解毒汤主要集中于病毒感染及炎症信号通路等。 结论 中研益肺解毒汤可能通过抗炎抗病毒等对COVID-19有潜在的防治作用。
Abstract:
Abstract: Objective To explore the components and mechanism of Zhongyan Yifei Jiedu Decoction in the prevention and treatment of COVID-19 based on network pharmacology and molecular docking.Methods TCMSP database was used to search the main components and targets of Zhongyan Yifei Jiedu Decoction;Cytascape constructs drug-active component-target network diagram;The same target protein of Zhongyan Yifei Jiedu Decoction and COVID-19 was analyzed for GO function enrichment and KEGG pathway enrichment;Molecular docking was used to study its binding activity.Results Zhongyan Yifei Jiedu Decoction screened 176 potential active ingredients and 280 corresponding targets,69 of which were closely related to diseases;The enrichment analysis of target pathway showed that Zhongyan Yifei Jiedu Decoction mainly concentrated on viral infection and inflammatory signal pathway.Conclusion Zhongyan Yifei Jiedu Decoction may have potential preventive and therapeutic effects on COVID-19 through anti-inflammation and anti-virus.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81800401);陕西省教育厅一般专项项目(22JK0348);陕西省科技厅一般项目(2022SF-207);陕西中医药大学附属医院院级项目(2020MS019)
更新日期/Last Update: 2023-03-27