[1]胡越 许兵兵.网络药理学预测人参抗抑郁作用机制[J].陕西中医药大学学报,2021,44(05):113-119.[doi:10.13424/j.cnki.jsctcm.2021.05.023]
　HU Yue XU Bingbing.Prediction of Antidepressant Mechanism of Ginseng by Network Pharmacology[J].Journal of Shaanxi University of Traditional Chinese Medicine,2021,44(05):113-119.[doi:10.13424/j.cnki.jsctcm.2021.05.023]
点击复制

网络药理学预测人参抗抑郁作用机制
分享到：

《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
44
期数:
2021年05期
页码:
113-119
栏目:
出版日期:
2021-09-30

文章信息/Info

Title:
Prediction of Antidepressant Mechanism of Ginseng by Network Pharmacology
文章编号:
2096-1340(2021)05-0113-07
作者:
胡越1 许兵兵2
1.江西卫生职业学院，江西 南昌 330052;
2.江西省中医药研究院,江西 南昌 330052
Author(s):
HU Yue1 XU Bingbing2
1.Jiangxi Health Vocational College,Nanchang 330052,China;
2.Jiangxi Academy of Traditional Chinese Medicine,Nanchang 330052,China
关键词:
人参; 抑郁症; 网络药理学; 作用靶点; 蛋白相互作用
Keywords:
Ginseng; Depression;  Network pharmacology;  Action target;  Protein interaction
分类号:
R285
DOI:
10.13424/j.cnki.jsctcm.2021.05.023
文献标志码:
A
摘要:
目的 研究人参治疗抑郁症的潜在分子机制。方法 通过网络药理学的方法，采用TCMSP数据库查询获取人参主要的活性成分，利用Drugbank、GeneCards、NCBI、OMIM等数据库筛选人参活性成分并预测人参抗抑郁的作用靶点。使用String数据库和Cytoscape软件绘制靶点蛋白相互作用网络，使用Cytoscape软件构建活性成分作用靶点的网络，采用DAVID数据库对靶点进行GO及KEGG通路分析。结果 经过筛选得到人参的活性成分17个，主要涉及的作用靶点有43个。网络分析结果表明，人参发挥抗抑郁药效过程中主要涉及代谢过程、细胞过程、对应激的应答等生物过程，通过调节Neuroactive ligandreceptor interaction、Toxoplasmosis、Pathways in cancer、Leishmaniasis、Serotonergic synapse、Osteoclast differentiation、Tuberculosis等信号通路来发挥抗抑郁作用。结论 人参中的活性化合物延胡索碱、豆甾醇、人参二醇山奈酚、花生四烯酸等能作用于AKT1、TNF、PPARG、APRB2、IL1β、PTGS2等靶点调节多条信号通路进行抗炎、调节突触等作用，从而可能发挥对抑郁症的治疗作用。
Abstract:
Objective To study the potential molecular mechanism of Ginseng in the treatment of depression.Methods Through the method of network pharmacology,the main active components of Ginseng were obtained by TCMSP database.The active components of Ginseng were screened by Drugbank,Genecards,NCBI,OMIM and other databases,and the antidepressant targets of Ginseng were predicted.String database and Cytoscape software were used to draw the target protein interaction network,Cytoscape software was used to construct the network of active ingredient action target,and DAVID database was used to analyze the go and KEGG pathways of the target.Results After screening,17 active components of Ginseng were obtained,and 43 targets were mainly involved.The results of network analysis showed that Ginseng mainly involved biological processes such as metabolic process,cellular process and response to stress in the process of exerting antidepressant effect,through regulating neuroactive live receptor interaction,toxoplasmosis,pathways in cancer,leishmaniasis,serotonic synapse,osteolast differentiation tuberculosis and other signaling pathways to play an antidepressant role.Conclusion Fumarine,stigmasterol,Panaxadiol,kaempferol and arachidonic acid can act on AKT1,TNF,PPARG,aprb2 and IL-1β、 PTGS2 and other targets regulate multiple signal pathways for antiinflammatory and synaptic regulation,which may play a role in the treatment of depression.

参考文献/References:

［1］Rhead JC.How to change your mind：what the new science of psychedelics teaches us about consciousness,dying,addiction,depression,and transcendence［J］.Psychoactive Drugs,2018，50(5)：460.
［2］Anthes E.Depression：a change of mind［J］.Nature,515,185-187(2014).
［3］Mathers CD,Loncar D.Projections of global mortality and burden of disease from 2002 to 2030［J］.PLoS Med.2006,3(11):e442-e462.
［4］Ma K,Zhang H,Baloch Z.Pathogenetic and therapeutic applications of tumor necrosis factoralpha(TNFalpha) in major depressive disorder：a systematic review［J］.Int.J.Mol.Sci,2016,17(5)：733-754.
［5］Consortium C.Sparse wholegenome sequencing identifies two loci for major depressive disorder［J］.Nature,2015,523(7562)：588-591.
［6］Price JL,Drevets WC.Neural circuits underlying the pathophysiology of mood disorders［J］.Trends Cogn.Sci.(Regul.Ed.)2012,16(1)：61-71.
［7］Williams LM.Precision psychiatry：a neural circuit taxonomy for depression and anxiety［J］.The lancet,Psychiatry 2016,3(5):472-480.
［8］Joshi A.Selective serotonin reuptake inhibitors：an overview［J］.Psychiatr.Danub.30(Suppl 7)(2018) 605-609.
［9］Cipriani A,Zhou X,DelGiovane C,et al,Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents：a network metaanalysis［J］.Lancet 2016,388(10047):881-890.
［10］黄社霄.人参,西洋参,三七药用探讨［J］.中国中医药现代远程教育,2011,9(15)：73-74.
［11］杨武韬.人参的化学成分和药理研究进展［J］.中国医药指南,2014,12(3)：33-34.
［12］吴德琳,刘娟,郑思道.人参活性成分及人参复方制剂对细胞色素P450酶调节作用的研究进展［J］.中西医结合心脑血管病杂志，2016,14(16):1874-1876.
［13］李倩,柴艺汇,高洁,等,人参现代药理作用研究进展［J］.贵阳中医学院学报,2019,41(5):89-92.
［14］Xu X,Zhang WX,Huang C,et al.A Novel chemometric method for the prediction of human oral bioavailability［J］.Int.J.Mol.Sci.2012,13:6964-6982.
［15］Walters WP,Murcko MA.Prediction of ‘DrugLikeness［J］.Adv.Drug Deliver.Rev.2002,54,255-271.
［16］Karege F,Perroud N,Burkhardt S,et al.Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase3beta in ventral prefrontal cortex of depressed suicide victims［J］.Biol Psychiatry.2007,61(2)：240-245.
［17］Kalkman HO.The role of the phosphatidylinositide 3kinaseprotein kinase B pathway in schizophrenia［J］.Pharmacol Ther.2006,110(1)：117-134.
［18］Dowlati Y,Herrmann N,Swardfager W,et al.A metaanalysis of cytokines in major depression［J］.Biol Psychiatry,2010,67(5)：446-457.
［19］Boomsma DI,Willemsen G,Sullivan PF,et al.Genomewide association of major depression：description of samples for the GAIN Major Depressive Disorder Study：NTR and NESDA biobank projects［J］.Eur J Hum Genet,2008,16(3)：335-342.
［20］Schmidt FM,Kirkby KC,Himmerich H.The TNFα inhibitor etanercept as monotherapy in treatmentresistant depressionreport of two cases［J］.Psychiatr Danub,2014,26(3)：288-290.
［21］Krügel U,Fischer J,Radicke S,et al.Antidepressant effects of TNFα blockade in an animal model of depression［J］.J Psychiatr Res,2013,47(5)：611-616.
［22］吴丹,高耀,向欢,等.基于网络药理学的柴胡抗抑郁作用机制研究［J］.药学学报,2018.53(2):210-219.
［23］朱珂璇,邵晓,王昕,等.人参抗抑郁作用及机制的研究进展［J］.世界科学技术—中医药现代化,2016,18(9):1583-1588.
［24］Lee B,Kim H,Shim I,et al.Wild ginseng attenuates anxiety and depressionlike behaviors during morphine withdrawal［J］.J Microbiol Biotechnol,2011,21(10)：1088-1096.
［25］Kim NH,Kim KY,Jeong HJ,et al.Antidepressantlike effect of altered Korean red ginseng in mice［J］.Behav Med,2011,37(2)：42-46.
［26］曲苏晨,曹 程,戚明珠,等.中药复方开心散调控慢性压力应激小鼠海马炎性细胞因子水平抗抑郁作用机制研究［J］.世界科学技术中医药现代化，2019，21(11)：2302-2309.
［27］王佳,谢健,陈岳明,等.山奈酚对乳腺癌抑郁模型大鼠的抗抑郁作用研究［J］.中国现代应用药学,2016,33(3)：277-280.
［28］乔卫.荜茇果实中的胡椒碱对单胺氧化酶的抑制作用及抗抑郁活性［J］.国外医药(植物药分册),2006,21(6)：266-267.
［29］任思宇,王真真,陈乃宏.人参皂苷抗抑郁作用研究进展［J］.药学学报,2019,54(12)：2204-2208.
［30］宋璐.以海马PPARα为新型抗抑郁靶点的相关研究［D］.南通：南通大学,2017.

相似文献/References:

[1]刘 娟,田 　磊,王 　曼,等.电针对慢性应激抑郁模型大鼠脑组织中大麻素受体ＣＢ１的影响[J].陕西中医药大学学报,2019,(03):064.[doi:10.13424/j.cnki.jsctcm.2019.03.018]
　Liu Juan Tian Lei Wang Man Lu Jian Lei Zhengquan.Effect of Electroacupuncture on Cannabinoid Receptor CB1 in Brain Tissue of Rats with Chronic Stress Depression[J].Journal of Shaanxi University of Traditional Chinese Medicine,2019,(05):064.[doi:10.13424/j.cnki.jsctcm.2019.03.018]
[2]侯 文,柏鲁宁,赵晓平,等.健脾解郁法在脑卒中后肝郁脾虚型抑郁症中的临床应用[J].陕西中医药大学学报,2019,(03):082.[doi:10.13424/j.cnki.jsctcm.2019.03.022]
[3]曾霖１ 李惠林２ 赵恒侠２ 刘德亮２ 楚淑芳２ 指导：张学文３.张学文国医大师从肝论治抑郁症经验[J].陕西中医药大学学报,2019,(01):009.[doi:10.13424/j.cnki.jsctcm.2019.01.003]
[4]李正欢 宋雪利 王飞 陈杨梁杨.浅论基于苗医理论的广谱抗肿瘤复方参棱夏[J].陕西中医药大学学报,2020,(5):066.[doi:10.13424/j.cnki.jsctcm.2020.05.017]
　Li Zhenghuan,Song Xueli,Wang Fei,et al.A Discussion on the Broad - spectrum Antitumor Compound Shen Leng Xia Based on Theories of Miao Medicine[J].Journal of Shaanxi University of Traditional Chinese Medicine,2020,(05):066.[doi:10.13424/j.cnki.jsctcm.2020.05.017]
[5]陈奕晨 王娜 王文杰**.淫羊藿抗抑郁作用机制的网络药理学研究[J].陕西中医药大学学报,2021,44(02):053.[doi:10.13424/j.cnki.jsctcm.2021.02.012]
　CHEN Yi - chen,WANG Na,WANG Wen jie.Network Pharmacology Study on Antidepressant Mechanism of Epimedium[J].Journal of Shaanxi University of Traditional Chinese Medicine,2021,44(05):053.[doi:10.13424/j.cnki.jsctcm.2021.02.012]

备注/Memo

备注/Memo:
基金项目：江西省卫健委中医药科研计划课题（2018A076）
更新日期/Last Update: 2021-09-23