[1]胡剑威丁超吴莹张玉莹龚传明张东东王薇.青藤碱及其制剂治疗类风湿性关节炎的研究进展[J].陕西中医药大学学报,2024,(03):001-7.[doi:10.13424/j.cnki.jsctcm.2024.03.001]
　HU JianweiDING ChaoWU YingZHANG Yuying GONG ChuanmingZHANG DongdongWANG Wei.Research Progress on the Treatment of Rheumatoid Arthritis with Sinomenine and Its Preparations[J].Journal of Shaanxi University of Traditional Chinese Medicine,2024,(03):001-7.[doi:10.13424/j.cnki.jsctcm.2024.03.001]
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青藤碱及其制剂治疗类风湿性关节炎的研究进展()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2024年03期
页码:
001-7
栏目:
出版日期:
2024-07-01

文章信息/Info

Title:
Research Progress on the Treatment of Rheumatoid Arthritis with Sinomenine and Its Preparations
文章编号:
2096-1340(2024)03-0001-07
作者:
胡剑威1丁超2吴莹2张玉莹2龚传明2张东东2王薇2
1.武威市凉州医院，甘肃 武威 733000；
2.陕西中医药大学药学院，陕西 咸阳 712046
Author(s):
HU Jianwei1DING Chao2WU Ying2ZHANG Yuying2 GONG Chuanming2ZHANG Dongdong2WANG Wei2
1.Liangzhou Hospital in Wuwei City,Gansu Wuwei 733000,China;
2.School of Pharmacy,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China
关键词:
关键词：青风藤; 青藤碱; 类风湿关节炎; 作用机制
Keywords:
Key words：Qingfengteng; Qingteng alkaloid; Rheumatoid arthritis; Mechanism of action
分类号:
R285.6
DOI:
10.13424/j.cnki.jsctcm.2024.03.001
文献标志码:
A
摘要:
摘要：类风湿性关节炎（rheumatoid arthritis，RA）是一种自身免疫障碍性疾病，发病率高，好发于中年女性，严重影响患者的运动能力。目前，关乎其发病机制尚未完全明确，现有的治疗方案也仅停留在延缓病情、改善关节功能为目标。青藤碱是青风藤中的一种有效成分，具有抗炎、镇痛、免疫抑制、抗肿瘤等多种药理活性，其在治疗类风湿性关节炎方面颇有成效，主要通过缓解炎症、抑制滑膜增生、减轻骨破坏等途径，且联合用药的效果更佳。目前，市面上也出现了许多有关青藤碱的复方制剂，比如：除痹活络方、秦息痛片等，均表现出良好的抗RA作用，且不良反应较小。因此，基于青藤碱抗RA的相关研究，对青藤碱治疗类风湿性关节炎的作用机制及其复方制剂研究进行综述，以期为其以后的开发利用提供参考依据。
Abstract:
Abstract： Rheumatoid arthritis (RA) is an autoimmune disease with a high incidence rate,which tends to occur in middle-aged women and seriously affects the motor ability of patients.At present,the pathogenesis of the disease is not fully understood,and existing treatment plans only focus on delaying the condition and improving joint function.Qingteng alkaloid is an effective ingredient in Qingfengteng,which has various pharmacological activities such as anti-inflammatory,analgesic,immunosuppressive,anti-tumor,etc.It is quite effective in the treatment of rheumatoid arthritis,mainly by alleviating inflammation,inhibiting periosteal proliferation,reducing bone damage,and the combined use of drugs has a better effect.Nowadays,there are also many compound preparations related to sinomenine on the market,such as Qubi Huoluorecipe,Qinxitong tablet,etc.,all of which have shown good anti RA effects with minimal adverse reactions.Therefore,based on the relevant research on the anti RA effect of sinomenine,this article reviews the mechanism of action and compound preparations of sinomenine in the treatment of rheumatoid arthritis,in order to provide reference for its future development and utilization.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金项目（82104368）；陕西中医药大学创新团队项目（2023-CXTD-05）
更新日期/Last Update: 2024-05-20