[1]胡剑威丁超吴莹张玉莹龚传明张东东王薇.青藤碱及其制剂治疗类风湿性关节炎的研究进展[J].陕西中医药大学学报,2024,(03):001-7.[doi:10.13424/j.cnki.jsctcm.2024.03.001]
 HU JianweiDING ChaoWU YingZHANG Yuying GONG ChuanmingZHANG DongdongWANG Wei.Research Progress on the Treatment of Rheumatoid Arthritis with Sinomenine and Its Preparations[J].Journal of Shaanxi University of Traditional Chinese Medicine,2024,(03):001-7.[doi:10.13424/j.cnki.jsctcm.2024.03.001]
点击复制

青藤碱及其制剂治疗类风湿性关节炎的研究进展()
分享到:

《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2024年03期
页码:
001-7
栏目:
出版日期:
2024-05-20

文章信息/Info

Title:
Research Progress on the Treatment of Rheumatoid Arthritis with Sinomenine and Its Preparations
文章编号:
2096-1340(2024)03-0001-07
作者:
胡剑威1丁超2吴莹2张玉莹2龚传明2张东东2王薇2
1.武威市凉州医院,甘肃 武威 733000;
2.陕西中医药大学药学院,陕西 咸阳 712046
Author(s):
HU Jianwei1DING Chao2WU Ying2ZHANG Yuying2 GONG Chuanming2ZHANG Dongdong2WANG Wei2
1.Liangzhou Hospital in Wuwei City,Gansu Wuwei 733000,China;
2.School of Pharmacy,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China
关键词:
关键词:青风藤青藤碱类风湿关节炎作用机制
Keywords:
Key words:QingfengtengQingteng alkaloidRheumatoid arthritisMechanism of action
分类号:
R285.6
DOI:
10.13424/j.cnki.jsctcm.2024.03.001
文献标志码:
A
摘要:
摘要:类风湿性关节炎(rheumatoid arthritis,RA)是一种自身免疫障碍性疾病,发病率高,好发于中年女性,严重影响患者的运动能力。目前,关乎其发病机制尚未完全明确,现有的治疗方案也仅停留在延缓病情、改善关节功能为目标。青藤碱是青风藤中的一种有效成分,具有抗炎、镇痛、免疫抑制、抗肿瘤等多种药理活性,其在治疗类风湿性关节炎方面颇有成效,主要通过缓解炎症、抑制滑膜增生、减轻骨破坏等途径,且联合用药的效果更佳。目前,市面上也出现了许多有关青藤碱的复方制剂,比如:除痹活络方、秦息痛片等,均表现出良好的抗RA作用,且不良反应较小。因此,基于青藤碱抗RA的相关研究,对青藤碱治疗类风湿性关节炎的作用机制及其复方制剂研究进行综述,以期为其以后的开发利用提供参考依据。
Abstract:
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease with a high incidence rate,which tends to occur in middle-aged women and seriously affects the motor ability of patients.At present,the pathogenesis of the disease is not fully understood,and existing treatment plans only focus on delaying the condition and improving joint function.Qingteng alkaloid is an effective ingredient in Qingfengteng,which has various pharmacological activities such as anti-inflammatory,analgesic,immunosuppressive,anti-tumor,etc.It is quite effective in the treatment of rheumatoid arthritis,mainly by alleviating inflammation,inhibiting periosteal proliferation,reducing bone damage,and the combined use of drugs has a better effect.Nowadays,there are also many compound preparations related to sinomenine on the market,such as Qubi Huoluorecipe,Qinxitong tablet,etc.,all of which have shown good anti RA effects with minimal adverse reactions.Therefore,based on the relevant research on the anti RA effect of sinomenine,this article reviews the mechanism of action and compound preparations of sinomenine in the treatment of rheumatoid arthritis,in order to provide reference for its future development and utilization.

参考文献/References:

[1]中华医学会风湿病学分会.2018中国类风湿关节炎诊疗指南[J].中华内科杂志,2018,57(4):242-251.
[2]MCINNES IB,SCHETT G.Pathogenetic insights from the treatment of rheumatoid arthritis[J].The Lancet,2017,389(10086):2328-2337.
[3]石颖,邹庆华,张艳,等.类风湿关节炎疾病活动度与患者心理状态和认知功能的相关性研究[J].免疫学杂志,2018,34(12):1082-1089.
[4]姜泉.国际中医临床实践指南 类风湿关节炎(2019-10-11)[J].世界中医药,2020,15(20):3160-3168.
[5]LUO CH,XU XR,WEI XC,et al.Natural medicines for the treatment of fatigue:Bioactive components,pharmacology,and mechanisms[J].Pharmacological Research,2019,148:104409.
[6]中国科学院.中国植物志:第54卷[M].北京:中国科学出版社,1978.
[7]宋小妹,刘海静.太白七药研究与应用[M].北京:人民卫生出版社,2011:34-38.
[8]国家中医药管理局《中华本草》编委会.中华本草[M].上海:上海科学技术出版社,2009.
[9]李晓娟,王培训,刘良,等.青藤碱对T淋巴细胞活化及TH1类细胞内细胞因子表达的影响[J].中国免疫学杂志,2004,20(4):249-252,258.
[10]王国芬.青风藤汤对类风湿关节炎患者Tfh、IL-21及抗CCP抗体的影响[J].现代实用医学,2019,31(8):1005-1007.
[11]马丽文,于丹,吴军凯,等.中药及有效成分治疗类风湿关节炎的作用机制[J].河北医药,2020,42(18):2832-2836,2841.
[12]李凝,邓筠,周洁如,等.青藤碱对类风湿关节炎患者外周血辅助性T淋巴细胞17/调节性T淋巴细胞比例的影响[J].上海医学,2013,36(3):254-258.
[13]张欣悦.青藤碱对类风湿关节炎模型小鼠BMDC表面共刺激分子CD80/CD86的影响[D].成都:成都中医药大学,2016.
[14]梅湘.青藤碱对类风湿关节炎模型大鼠甘露糖受体表达及相关抗体影响的实验研究[D].成都:成都中医药大学,2014.
[15]赵远翠.青风藤碱抗炎作用及机制研究[D].昆明:云南中医药大学,2019.
[16]KIM TW,HAN JM,HAN YK,et al.Anti-inflammatory effects of Sinomenium acutum extract on endotoxin-induced uveitis in lewis rats[J].International Journal of Medical Sciences,2018,15(8):758-764.
[17]CHENG H,XIA B,GUO QS,et al.Sinomenine attenuates 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice[J].International Immunopharmacology,2007,7(5):604-611.
[18]陶丛珊.青藤碱在黑色素合成以及皮肤炎症中的作用及其外用制剂的初步研究[D].上海:第二军医大学,2017.
[19]JIANG Y,GAO M,WANG WM,et al.Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy[J].International Journal of Molecular Sciences,2015,16(2):2559-2573.
[20]ZHAO ZJ,XIAO J,WANG JC,et al.Anti-inflammatory effects of novel sinomenine derivatives[J].International Immunopharmacology,2015,29(2):354-360.
[21]邹飏,李浩,尚江荫子,等.青藤碱对前成骨细胞增殖、分化的影响及可能的作用机制[J].江西医药,2018,53(2):119-121.
[22]丁从珠,姚瑶,方芸,等.青藤碱对胶原诱导的关节炎大鼠血清OPG/RANKL、IL-17含量的影响[J].南京中医药大学学报,2012,28(4):330-333.
[23]张浩然,吉金雨,侯晓强,等.青藤碱抑制CaN/NFAT通路信号抑制CIA骨破坏的研究[J].中国免疫学杂志,2020,36(12):1447-1452.
[24]李嘉,付婷婷,张光峰,等.青藤碱通过miR-23b-3p/FGF9诱导人类风湿关节炎成纤维细胞样滑膜细胞凋亡[J].中国病理生理杂志,2020,36(9):1653-1660.
[25]徐佳.青风藤醇提物治疗类风湿性关节炎的疗效及其作用机制的探究[D].南京:南京中医药大学,2015.
[26]YI L,LYN YJ,PENG C,et al.Sinomenine inhibits fibroblast-like synoviocyte proliferation by regulating α7nAChR expression via ERK/Egr-1 pathway[J].International Immunopharmacology,2018,56:65-70.
[27]韩娟.青藤碱抗类风湿关节炎滑膜相关细胞因子的实验研究[D].成都:成都中医药大学,2013.
[28]欧阳琳.青风藤配伍黑顺片治疗类风湿关节炎药效作用研究[D].长沙:湖南中医药大学,2019.
[29]YANG WJ,CONG YZ.Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases[J].Cellular & Molecular Immunology,2021,18(4):866-877.
[30]KISHIKAWA T,MAEDA Y,NII T,et al.Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population[J].Annals of the Rheumatic Diseases,2020,79(1):103-111.
[31]JIANG ZM,ZENG SL,HUANG TQ,et al.Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation[J].Science Bulletin,2023,68(14):1540-1555.
[32]KOK TW,YUE PYK,MAK NK,et al.The anti-angiogenic effect of sinomenine[J].Angiogenesis,2005,8(1):3-12.
[33]MCINNES IB,SCHETT G.The pathogenesis of rheumatoid arthritis[J].New England Journal of Medicine,2011,365(23):2205-2219.

[34]BOTTINI N,FIRESTEIN GS.Duality of fibroblast-like synoviocytes in RA:passive responders and imprinted aggressors[J].Nature Reviews Rheumatology,2013,9(1):24-33.
[35]RIESNER K,SHI Y,JACOBI A,et al.Initiation of acute graft-versus-host disease by angiogenesis[J].Blood,2017,129(14):2021-2032.


[36]JEGATHEESWARAN J,TURK M,POPE JE.Comparison of Janus kinase inhibitors in the treatment of rheumatoid arthritis:a systemic literature review[J].Immunotherapy,2019,11(8):737-754.
[37]MYASOEDOVA E,DAVIS JM 3RD,CROWSON CS,et al.Epidemiology of rheumatoid arthritis:rheumatoid arthritis and mortality[J].Current Rheumatology Reports,2010,12(5):379-385.
[38]SEYLER TM.BLyS and APRIL in rheumatoid arthritis[J].Journal of Clinical Investigation,2005,115(11):3083-3092.
[39]BEVAART L,VERVOORDELDONK MJ,TAK PP.Collagen-induced arthritis in mice[J].Methods in molecular biology(Clifton,NJ.),2010:181-192.
[40]谢锐龙,徐伟,康贤通,等.青风藤方水煎剂改善类风湿关节炎患者关节症状近期疗效[J].中国临床康复,2003,7(24):3394.
[41]许超.青风藤制剂调控滤泡辅助性T细胞干预类风湿关节炎发病的研究[D].南京:南京中医药大学,2018.
[42]颉敏琴.除痹活络方治疗类风湿性关节炎45例[J].中国中医药科技,2019,26(6):912-914.
[43]倪丹红,刘丹,吕琴琴,等.秦息痛片联合传统抗风湿药治疗早期活动性类风湿关节炎临床研究[J].陕西中医,2019,40(4):484-486.
[44]程红卫,秦艳,胡筱娟.青白通痹胶囊的组方学研究[J].陕西中医,2019,40(4):537-539.
[45]刘恬园,胡筱娟,程红卫,等.青白通痹胶囊联合来氟米特和甲氨喋呤治疗寒湿痹阻型类风湿性关节炎30例[J].陕西中医药大学学报,2020,43(6):85-88.
[46]王英,臧艳红.正清风痛宁穴位注射治疗类风湿关节炎的临床观察[J].中国民间疗法,2018,26(13):114-115.
[47]周雯,张思胜,潘建西.正清风痛宁治疗骨关节炎68例[J].安徽中医临床杂志,2002,14(3):198.
[48]刘继华,张快强,吕正茂,等.通痹丸治疗膝骨关节炎90例[J].陕西中医,2005,26(3):219-220.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(82104368);陕西中医药大学创新团队项目(2023-CXTD-05)
更新日期/Last Update: 2024-05-20