[1]宋媛媛,杨龙,刘越洋,等.萎平舒胶囊对慢性萎缩性胃炎模型大鼠胃黏膜细胞自噬水平的影响[J].陕西中医药大学学报,2020,(06):053-58.[doi:10.13424/j.cnki.jsctcm.2020.06.012]
　Song Yuanyuan,Yang Long,Liu Yueyang,et al.Effect of Weipingshu Capsule on the Autophagy Level of Gastric Mucosal Cellsin in Chronic Atrophic Gastritis Model Rats[J].Journal of Shaanxi University of Traditional Chinese Medicine,2020,(06):053-58.[doi:10.13424/j.cnki.jsctcm.2020.06.012]
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萎平舒胶囊对慢性萎缩性胃炎模型大鼠胃黏膜细胞自噬水平的影响()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2020年06期
页码:
053-58
栏目:
出版日期:
2020-12-30

文章信息/Info

Title:
Effect of Weipingshu Capsule on the Autophagy Level of Gastric Mucosal Cellsin in Chronic Atrophic Gastritis Model Rats
文章编号:
2096-1340(2020)06-0053-06
作者:
宋媛媛; 杨龙; 刘越洋; 王癑; 张鹏; 黄雅慧
西安市中医医院,陕西西安710001
Author(s):
Song Yuanyuan;  Yang Long;  Liu Yueyang;  Wang Yue;  Zhang Peng;  Huang Yahui
Xi’an Hospital of Traditional Chinese Medicine, Xi’anShaanxi , 710001
关键词:
萎平舒胶囊; 慢性萎缩性胃炎; 胃黏膜细胞; 自噬水平; 健脾活血
Keywords:
Weipingshu Capsule;  chronic atrophic gastritis;  gastric mucosal cells;  autophagy level;  invigorating spleen and activating blood
分类号:
R573.3+2
DOI:
10.13424/j.cnki.jsctcm.2020.06.012
文献标志码:
A
摘要:
目的探讨萎平舒胶囊对慢性萎缩性胃炎伴异型增生模型大鼠胃黏膜细胞自噬水平的影响?方法60只Wistar大鼠中,随机选取8只作为正常对照组,其余以MNNG诱导法建立大鼠胃粘膜萎缩伴肠化的模型?随机分为模型组?萎平舒低剂量组?萎平舒高剂量组,分别观察大鼠胃黏膜组织病理学变化?胃窦胃体黏膜与肌层厚度变化,各组大鼠胃黏膜上皮细胞中自噬小体的变化?结果与模型组比较,萎平舒胶囊低?高剂量组窦部的胃粘膜厚度及肌层厚度与模型组比较显著增厚(P<0.01;P<0.01),萎平舒大剂量组细胞质内可见到较多的次级溶酶体,自噬样小
Abstract:
Objective To investigate the effect of Weipingshu ( soothing stomach) Capsule on the autophagy level of gastric mucosal cells in chronic atrophic gastritis rat model associated with dysplasia. Methods 8 were randomly selected as the normal control group among 60 Wistar rats, and the rest were induced by MNNG to establish a model of gastric mucosal atrophy with intestinal metaplasia, and randomly divided into model group, Weipingshu low - dose group and Weipingshu high - dose group. The histopathological changes of gastric mucosa, gastric antrum and gastric body mucosa and muscle layer thickness as well as the gastric mucosal epithelial cells changes in autophagosomes of each group were observed respectively. Results Compared with the model group, the thickness of gastric mucosa and muscle layer in the antrum of the Weipingshu capsule low and high dose groups was significantly higher than that of the model group ( P <0.01; P <0. 01) . The secondary? lysosome in the Weipingshu high dose groupvisible is visible with more autophagy – like bodies. Conclusion Weipingshu Capsule can significantly improve the abnormal morphology of gastric mucosal epithelial cells and gland atrophy, increasing the number of autophagosomes in gastric mucosal epithelial cells.

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备注/Memo

备注/Memo:
基金项目:陕西省中医管理局中医药科研项目资助课题(JCPT033)
通讯作者:杨龙,医学博士,主治医师?E-mail:eastw@126.com
更新日期/Last Update: 2020-11-26