[1]张美玲 王祯芝 熊康李雄 周锋.COVID-2019肝损伤中西医发生机制研究进展[J].陕西中医药大学学报,2023,(03):001-6.[doi:10.13424/j.cnki.jsctcm.2023.03.001]
　ZHANG Meiling WANG Zhenzhi XIONG Kang LI XiongZHOU Feng.Research Progress on Pathogenesis of Liver Injury inCOVID-2019 in Chinese and Western medicine[J].Journal of Shaanxi University of Traditional Chinese Medicine,2023,(03):001-6.[doi:10.13424/j.cnki.jsctcm.2023.03.001]
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COVID-2019肝损伤中西医发生机制研究进展
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2023年03期
页码:
001-6
栏目:
疫病防治
出版日期:
2023-05-31

文章信息/Info

Title:
Research Progress on Pathogenesis of Liver Injury in COVID-2019 in Chinese and Western medicine
文章编号:
2096-1340(2023)03-0001-06
作者:
张美玲1 王祯芝1 熊康1李雄1 周锋2
1.陕西中医药大学，陕西 咸阳 712046；
2.陕西中医药大学附属医院,陕西 咸阳 712046
Author(s):
ZHANG Meiling1 WANG Zhenzhi1 XIONG Kang1 LI Xiong1ZHOU Feng2
1.Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;
2 Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China
关键词:
关键词：冠状病毒; 新型冠状病毒肺炎; 肝损伤; 中医; 西医; 发病机制
Keywords:
Key words： Coronavirus; COVID-19; Liver injury; Chinese medicine; Western medicine; Pathogenesis
分类号:
R245.2
DOI:
10.13424/j.cnki.jsctcm.2023.03.001
文献标志码:
A
摘要:
摘 要：在冠状病毒肺炎2019（Corona Virus Disease，COVID-2019）的背景下，发生肝毒性患者并不少见，从既往无肝病的化学改变到有基础肝病的进行性失代偿期均可见。目前对新冠肺炎肝损伤发病机制尚不明确，从现代医学角度有直接病毒、细胞因子风暴、药物相关、低氧血症、凝血机制障碍、肾素-血管紧张素系统（Renin-Angiotensin System,RAS）等，中医学认为可能与气机升降失常、五行乘悔、经络相互贯通等有关。另外，运藏失调、阴阳失衡等可能也参与肝损伤，或存在各因素间相互作用的复杂机制。在未来的研究中，应继续从现代医学和传统中医理论的角度深入探究新型冠状病毒的作用机制，寻找不同途径的信号传递及生物化学方面的作用，为进一步提高临床应用提供科学、有效的治疗依据。
Abstract:
Abstract： In the context of COVID-2019,hepatotoxicity is not uncommon.It can be seen from chemical changes without liver disease to progressive decompensation with underlying liver disease.At present,the pathogenesis of COVID-19 liver injury is not clear.From the perspective of modern medicine,there are direct viruses,cytokine storms,drug-related,hypoxemia,coagulation mechanism disorders,Renin Angiotensin System (RAS),etc.Traditional medicine believes that it may be related to the abnormal rise and fall of Qi,the five elements riding and aggressive,and the interconnection of meridians.In addition,transport and storage disorders,and Yin Yang imbalance may also be involved in liver injury,or there may be complex mechanisms of interaction among various factors.In the future research,we should continue to explore the mechanism of action of COVID-19 from the perspective of modern medicine and traditional Chinese medicine theory,look for different ways of signal transmission and biochemical effects,and provide scientific and effective therapeutic evidence for further improving clinical application.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金面上项目（81873387,82074552）；国家中医药创新骨干人才项目（〔2019〕128号）；陕西中医药大学培养计划项目（2017SZKY-018）；陕西省咸阳市中青年科技领军人才培育项目（2019k01-52）
更新日期/Last Update: 2023-05-19