[1]田王琪 张蔚桐 汪一凡 郭惠 王育伟.中药多糖通过调控肠道菌群干预肺癌的文献研究[J].陕西中医药大学学报,2023,(02):027-35.[doi:10.13424/j.cnki.jsctcm.2023.02.005 ]
　TIAN Wangqi ZHANG Weitong WANG Yifan GUO Hui WANG Yuwei TANG Yuping.Research Progress of Chinese Herbal Polysaccharides Intervening Lung Cancer by Regulating Intestinal Flora[J].Journal of Shaanxi University of Traditional Chinese Medicine,2023,(02):027-35.[doi:10.13424/j.cnki.jsctcm.2023.02.005 ]
点击复制

中药多糖通过调控肠道菌群干预肺癌的文献研究
分享到：

《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2023年02期
页码:
027-35
栏目:
肠道菌群专题
出版日期:
2023-05-13

文章信息/Info

Title:
Research Progress of Chinese Herbal Polysaccharides Intervening Lung Cancer by Regulating Intestinal Flora
文章编号:
2096-1340(2023)02-0027-09
作者:
田王琪 张蔚桐 汪一凡 郭惠 王育伟
陕西中医药大学，陕西 咸阳 712046
Author(s):
TIAN Wangqi ZHANG Weitong WANG Yifan GUO Hui WANG Yuwei TANG Yuping
Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China
关键词:
关键词：中药多糖; 肺癌; 肠道菌群; 糖代谢; 肠道屏障
Keywords:
Key words: Polysaccharides of Chinese herbal; Lung cancer; Intestinal flora; Glucose metabolism; Intestinal barrier
分类号:
R256.1
DOI:
10.13424/j.cnki.jsctcm.2023.02.005
文献标志码:
A
摘要:
摘 要：中药多糖是一类具有广泛药理活性的化合物，其对肺癌细胞的增殖抑制及其与化疗药物的联合应用均对肺癌的治疗有一定效果。此外，肠道菌群组成与功能的失衡与癌症的发生发展密切相关。中药多糖可与肠道菌群相互作用，通过调整肠道菌群丰度及修复受损的肠道屏障，对肺癌的治疗产生积极作用。因此，从不同中药多糖对肺癌的治疗及部分中药多糖对肺癌肠道菌群的影响进行综述，以期为中药多糖治疗肺癌的作用机制研究和抗肺癌中药新药的进一步研发提供参考。。
Abstract:
Abstract： Polysaccharide of chinese herbal is a kind of compound with extensive pharmacological activities.Its inhibition of proliferation of lung cancer cells and its combined application with chemotherapy drugs have certain effects on the treatment of lung cancer.In addition,the imbalance of intestinal flora composition and function is closely related to the occurrence and development of cancer.Chinese herbal polysaccharides can interact with intestinal flora,and play a positive role in the treatment of lung cancer by adjusting the abundance of intestinal flora and repairing the damaged intestinal barrier.Therefore,the treatment of lung cancer by different Chinese herbal polysaccharides and the effect of some Chinese herbal polysaccharides on intestinal flora of lung cancer are reviewed in order to provide references for the study of the mechanism of Chinese herbal polysaccharides in the treatment of lung cancer and the further development of new anti-lung cancer drugs.

参考文献/References:

［1］本刊讯.国家癌症中心发布最新一期全国癌症统计数据[J].上海护理,2022,22(4):72.
[2]林文苑,唐杰,曾波航.手术治疗局限期小细胞肺癌疗效的Meta分析[J].中山大学学报(医学科学版),2015,36(6):943-948.
[3]Shepherd FA.Surgery for limited stage small cell lung cancer:time to fish or cut bait[J].Journal of Thoracic Oncology,2010,5(2):147-149.
[4]朱慧,王绿化.放射治疗对小细胞肺癌预后的影响[J].中华肿瘤防治杂志,2010,17(24):2070-2074.
[5]白睿,袁程.抗血管生成治疗在肿瘤中的研究进展[J].中华生物医学工程杂志,2021(5):575-580.
[6]张爽,柳菁菁,杨长良,等.PARP抑制剂在小细胞肺癌的研究进展[J].中国肺癌杂志,2020,23(9):806-810.
[7]王硕,邓云天,彭欢,等.非小细胞肺癌免疫检查点抑制剂治疗进展[J/OL].协和医学杂志:1-10[2022-09-24].http://kns.cnki.net/kcms/detail/11.5882.r.20220808.1543.006.html.
[8]罗幸波,胡克辉,杨海霞,等.小细胞肺癌治疗近况[J].系统医学,2021,6(21):195-198.
[9]沈琦.中药治疗中晚期非小细胞肺癌的系统评价及用药规律分析初探[D].天津:天津中医药大学,2020.
[10]陈润泽,李鹏飞,胡雨奇,等.肠道菌群在中药代谢中的作用[J].中国微生态学杂志,2018,30(8):990-993.
[11]郑雁雪,王圆圆,王琳,等.中药配伍减毒的现代研究及思考[J/OL].中草药:1-10[2022-09-24].http://kns.cnki.net/kcms/detail/12.1108.R.20220831.0927.002.html.
[12]卢晶,张爱霞.中药材资源分布及利用前景:评《中国中药区划》[J].中国农业资源与区划,2020,41(5):256,300.
[13]Sun H,Zhang LJ,Sui BW,et al.The effect of terpenoid natural Chinese medicine molecular compound on lung cancer treatment[J].Evidence-Based Complementary and Alternative Medicine:ECAM,2021,2021:3730963.
[14]Zeng PJ,Li J,Chen YL,et al.The structures and biological functions of polysaccharides from traditional Chinese herbs[J].Progress in Molecular Biology and Translational Science,2019,163:423-444.
[15]Mao QX,Jiang F,Yin R,et al.Interplay between the lung microbiome and lung cancer[J].Cancer Letters,2018,415:40-48.
[16]Chen J,Domingue JC,Sears CL.Microbiota dysbiosis in select human cancers:evidence of association and causality[J].Seminars in Immunology,2017,32:25-34.
[17]Dzutsev A,Goldszmid RS,Viaud S,et al.The role of the microbiota in inflammation,carcinogenesis,and cancer therapy[J].European Journal of Immunology,2015,45(1):17-31.
[18]张维全.人类口腔及肠道微生态菌群多样性变化与非小细胞肺癌的相关性研究[D].济南:山东大学,2019.
[19]沈洁心,逯茂洋.肠道菌群的检测方法及最新研究进展[J].世界最新医学信息文摘,2017,17(A2):85,87.
[20]张大永,王云,吕敏,等.肠道菌群失调相关疾病及检测方法研究进展[J].中药与临床,2018,9(4):67-71.
[21]van den Bogert B,Erkus O,Boekhorst J,et al.Diversity of human small intestinal Streptococcus and Veillonella populations[J].FEMS Microbiology Ecology,2013,85(2):376-388.
[22]Wampach L,Heintz-Buschart A,Hogan A,et al.Colonization and succession within the human gut microbiome by Archaea,bacteria,and microeukaryotes during the first year of life[J].Frontiers in Microbiology,2017,8:738.
[23]Lim ES,Rodriguez C,Holtz LR.Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community[J].Microbiome,2018,6(1):87.
[24]Huttenhower C,Gevers D,Knight R,et al.Structure,function and diversity of the healthy human microbiome[J].Nature,2012,486(7402):207-214.
[25]Angelakis E,Bachar D,Henrissat B,et al.Glycans affect DNA extraction and induce substantial differences in gut metagenomic studies[J].Scientific Reports,2016,6:26276.
[26]Zhuang H,Cheng L,Wang Y,et al.Dysbiosis of the gut microbiome in lung cancer[J].Frontiers in Cellular and Infection Microbiology,2019,9:112.
[27]Wu CY,Ke Y,Zeng YF,et al.Anticancer activity of Astragalus polysaccharide in human non-small cell lung cancer cells[J].Cancer Cell International,2017,17:115.
[28]张时文,王欣,张小军.黄芪多糖对人肺癌细胞迁移的抑制作用机制研究[J].中国临床药理学杂志,2020,36(9):1124-1127.
[29]Zhao LC,Zhong YT,Liang J,et al.Effect of Astragalus polysaccharide on the expression of VEGF and EGFR in mice with lewis transplantable lung cancer[J].Journal of the College of Physicians and Surgeons—Pakistan:JCPSP,2019,29(4):392-394.
[30]杨琪,段俊颖,王雪林,等.黄芪多糖对肺癌A549细胞自噬的作用及机制研究[J].中国临床药理学杂志,2022,38(12):1329-1333.
[31]Zhang YM,Liu YQ,Liu D,et al.The effects of Astragalus polysaccharide on bone marrow-derived mesenchymal stem cell proliferation and morphology induced by A549 lung cancer cells[J].Med Sci Monit,2019,25:4110-4121.
[32]Zhou LJ,Liu ZJ,Wang ZX,et al.Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo[J].Scientific Reports,2017,7:44822.
[33]廖双叶.蜜炙黄芪多糖诱导肿瘤细胞免疫原性死亡的实验研究[D].广州:广东药科大学,2017.
[34]Pang GB,Chen C,Liu Y,et al.Bioactive polysaccharide nanoparticles improve radiation-induced abscopal effect through manipulation of dendritic cells[J].ACS Applied Materials & Interfaces,2019,11(45):42661-42670.
[35]肖小龙,莫观,廉云,等.大分子灵芝多糖对非小细胞肺癌细胞增殖、迁移和侵袭能力的抑制作用[J].上海中医药大学学报,2018,32(6):56-60.
[36]Hsu WH,Qiu WL,Tsao SM,et al.Effects of WSG,a polysaccharide from Ganoderma lucidum,on suppressing cell growth and mobility of lung cancer[J].International Journal of Biological Macromolecules,2020,165(Pt A):1604-1613.
[37]李志强,何玉霞.灵芝多糖对人肺癌A549细胞增殖凋亡的作用[J].现代食品科技,2021,37(5):38-42.
[38]Qiu WL,Hsu WH,Tsao SM,et al.WSG,a glucose-rich polysaccharide from Ganoderma lucidum,combined with cisplatin potentiates inhibition of lung cancer in vitro and in vivo[J].Polymers,2021,13(24):4353.
[39]Zhao JP,Wang YY.Experimental study of the A549 cell apoptosis of human non-small cell lung cancer induced by ginseng polysaccharide in vitro[J].Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi,2006,26(Suppl):95-97.
[40]贺晓静,陈广伟.人参多糖体外抑制人非小细胞肺癌A549细胞作用研究[J].中华实用诊断与治疗杂志,2013,27(11):1097-1098.
[41]Shin MS,Hwang SH,Yoon TJ,et al.Polysaccharides from ginseng leaves inhibit tumor metastasis via macrophage and NK cell activation[J].International Journal of Biological Macromolecules,2017,103:1327-1333.
[42]Lee DY,Park CW,Lee SJ,et al.Anti-cancer effects of Panax ginseng berry polysaccharides via activation of immune-related cells[J].Frontiers in Pharmacology,2019,10:1411.
[43]王敏,孔德军,杨莉,等.人参多糖注射液联合TP方案对晚期非小细胞肺癌患者Th1/Th2免疫平衡和血清肿瘤标志物的影响[J].现代生物医学进展,2022,22(7):1352-1356.
[44]Ma JJ,Liu HP,Wang XL.Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer[J].Journal of Traditional Chinese Medicine = Chung i Tsa Chih Ying Wen Pan,2014,34(6):641-645.
[45]赵俊霞.刺五加多糖对人小细胞肺癌H446细胞的抑制作用及免疫调节作用研究[D].石家庄:河北医科大学,2008.
[46]Sun D,Chen J,Hu H,et al.Acanthopanax senticosus polysaccharide suppressing proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells is associated with Wnt/β-catenin signaling[J].Neoplasma,2019,66(4):555-563.
[47]Huang DB,Ran RZ,Yu ZF.Effect of Acanthopanax senticosus injection on the activities of human tumor necrosis factor and natural killer cell in blood in the patients with lung cancer[J].Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica,2005,30(8):621-624.
[48]苗玉荣.香菇多糖对Lewis肺癌小鼠P53、Bcl-2蛋白表达及细胞凋亡的影响[D].沈阳:辽宁中医药大学,2006.
[49]邓声明.香菇多糖通过调节IFNγ的分泌来抑制肿瘤血管的功能[D].苏州:苏州大学,2018.
[50]Zhao CC,Yan HF,Pang WT,et al.Lentinan combined with cisplatin for the treatment of non-small cell lung cancer[J].Medicine,2021,100(12):e25220.
[51]董娅,赵钰玲,范亚莉,等.红花多糖对人非小细胞肺癌A549细胞增殖和凋亡的影响[J].临床肺科杂志,2017,22(11):2045-2048.
[52]Li JY,Yu J,Du XS,et al.Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway[J].Oncology Reports,2016,36(1):147-154.
[53]王婷婷.红花多糖抑制肺癌细胞系发生上皮间质化转化的机制研究[D].哈尔滨:黑龙江中医药大学,2016.
[54]Shi XK,Ruan DQ,Wang YX,et al.Anti-tumor activity of safflower polysaccharide (SPS) and effect on cytotoxicity of CTL cells,NK cells of T739 lung cancer in mice[J].Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica,2010,35(2):215-218.
[55]张晓莉,赵富生,武庚,等.红花多糖对小鼠Lewis肺癌移植瘤生长及转移的影响[J].国际免疫学杂志,2010,33(6):486-489.
[56]Tian H,Liu ZJ,Pu YW,et al.Immunomodulatory effects exerted by Poria cocos polysaccharides via TLR4/TRAF6/NFκB signaling in vitro and in vivo[J].Biomedicine & Pharmacotherapy,2019,112:108709.
[57]张密霞,李怡文,张德生,等.茯苓多糖对Lewis肺癌小鼠自发肺转移的抑制作用及其机制研究[J].现代药物与临床,2013,28(6):842-846.
[58]Lin TY,Lu MK,Chang CC.Structural identification of a fucose-containing 1,3-β-mannoglucan from Poria cocos and its anti-lung cancer CL1-5 cells migration via inhibition of TGFβR-mediated signaling[J].International Journal of Biological Macromolecules,2020,157:311-318.
[59]李琳琳.茯苓多糖联合顺铂对Lewis肺腺癌移植瘤的抑瘤作用及VEGF、p-STAT3、CD31表达的影响[D].张家口:河北北方学院,2021.
[60]魏科,陈勇超,周家豪,等.茯苓多糖辅助抗肺癌及免疫调节作用研究[J].中华中医药杂志,2020,35(10):4937-4940.
[61]Ye GY,Li J,Zhang JH,et al.Structural characterization and antitumor activity of a polysaccharide from Dendrobium wardianum[J].Carbohydrate Polymers,2021,269:118253.
[62]葛基春.霍山石斛体内外抗Lewis肺癌作用研究[D].合肥:合肥工业大学,2018.
[63]庞晨,张锡流,张秀玲,等.鲜铁皮石斛对肺腺癌裸鼠移植瘤中自噬及抑癌基因表达的影响[J].医药导报,2021,40(2):163-169.
[64]葛颖华,王杰,杨锋,等.鲜铁皮石斛多糖对Lewis肺癌小鼠免疫功能的影响[J].浙江中医杂志,2014,49(4):277-279.
[65]王杰,葛颖华,周萃,等.鲜铁皮石斛提取物抗Lewis肺癌的机制研究[J].中国现代应用药学,2014,31(8):953-957.
[66]胡同晨,果然,魏晓琼,等.白花蛇舌草通过抑制CXCR3的表达调控非小细胞肺癌细胞A549凋亡的机制研究[J].标记免疫分析与临床,2020,27(12):2164-2170.
[67]毛宇.白花蛇舌草多糖对非小细胞肺癌A549细胞作用机理研究[D].长沙:湖南农业大学,2015.
[68]Lin LY,Cheng KL,He Z,et al.A polysaccharide from Hedyotis diffusa interrupts metastatic potential of lung adenocarcinoma A549 cells by inhibiting EMT via EGFR/Akt/ERK signaling pathways[J].International Journal of Biological Macromolecules,2019,129:706-714.
[69]Lin LY,Cheng KL,Xie ZQ,et al.Purification and characterization a polysaccharide from Hedyotis diffusa and its apoptosis inducing activity toward human lung cancer cell line A549[J].International Journal of Biological Macromolecules,2019,122:64-71.
[70]贾羲,王娟,贾文瑞,等.白花蛇舌草多糖对Lewis肺癌小鼠肿瘤抑制作用及机制研究[J].中医学报,2021,36(1):143-147.
[71]肖琳,白秀珍,杨学东.枸杞多糖对人肺癌A549细胞影响的研究[J].数理医药学杂志,2006,19(2):130-132.
[72]肖琳,王平,崔涛,等.枸杞多糖对人肺癌A549细胞凋亡及Survivin表达的影响[J].时珍国医国药,2011,22(12):2917-2918.
[73]韩何丹,韩照玉,杜月梅,等.枸杞多糖联合顺铂对人肺腺癌细胞A549氧化损伤及凋亡的影响[J].食品科学,2020,41(15):194-200.
[74]Lu CX,Cheng BQ.Radiosensitizing effects of Lycium barbarum polysaccharide for Lewis lung cancer[J].Zhong Xi Yi Jie He Za Zhi,1991,11(10):611-612,582.
[75]Wei SY,Zhang PX,Han N,et al.Effects of Hedysari polysaccharides on regeneration and function recovery following peripheral nerve injury in rats[J].The American Journal of Chinese Medicine,2009,37(1):57-67.
[76]刘华,闫立萍,王小军.红芪多糖1联合顺铂对肺癌A549细胞凋亡的协同作用及其机制探讨[J].肿瘤,2013,33(11):980-984.
[77]闫立萍,刘华,王小军,等.红芪多糖1联合吉非替尼对肺癌A549细胞凋亡的作用及机制探讨[J].国际呼吸杂志,2020,40(16):1216-1220.
[78]侯亚琴.黄精通过AMPK/PDH轴调控M2巨噬细胞极化并抑制肺癌细胞迁移[D].合肥:安徽医科大学,2022.
[79]龙婷婷.基于TLR4-MAPK/NF-κB信号通路探讨黄精多糖免疫调节抗肿瘤作用机制研究[D].重庆:重庆医科大学,2018.
[80]Long T,Liu Z,Shang J,et al.Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-κB signaling pathways[J].International Journal of Biological Macromolecules,2018,111:813-821.
[81]赵冲.三七多糖对肺癌细胞A549的作用研究[D].新乡:新乡医学院,2015.
[82]谭庆龙,周昌园,刘春萍,等.猪苓多糖对人巨噬细胞形态及免疫功能的影响[J].中华中医药杂志,2018,33(5):1891-1896.
[83]Tabarsa M,Dabaghian EH,You SG,et al.The activation of NF-κB and MAPKs signaling pathways of RAW264.7 murine macrophages and natural killer cells by fucoidan from Nizamuddinia zanardinii[J].International Journal of Biological Macromolecules,2020,148:56-67.
[84]刘月新,刘倩倩,廖颖妍,等.玉竹多糖结构特征及其降糖生物活性研究进展[J].现代中药研究与实践,2022,36(1):98-102.
[85]王婷婷,周海燕,王亚贤,等.中药多糖抗肺癌作用研究进展[J].中医药学报,2016,44(2):92-95.
[86]Fang QY,Hu JL,Nie QX,et al.Effects of polysaccharides on glycometabolism based on gut microbiota alteration[J].Trends in Food Science & Technology,2019,92:65-70.
[87]Fang F,Tuncil YE,Luo X,et al.Shear-thickening behavior of gelatinized waxy starch dispersions promoted by the starch molecular characteristics[J].International Journal of Biological Macromolecules,2019,121:120-126.
[88]Shang QS,Jiang H,Cai C,et al.Gut microbiota fermentation of marine polysaccharides and its effects on intestinal ecology:an overview[J].Carbohydrate Polymers,2018,179:173-185.
[89]Xu XF,Xu PP,Ma C,et al.Gut microbiota,host health,and polysaccharides[J].Biotechnology Advances,2013,31(2):318-337.
[90]Hamaker BR,Tuncil YE.A perspective on the complexity of dietary fiber structures and their potential effect on the gut microbiota[J].Journal of Molecular Biology,2014,426(23):3838-3850.
[91]胡婕伦.大粒车前子多糖体内外消化与酵解特征体系构建及其促进肠道健康的作用[D].南昌:南昌大学,2014.
[92]施青青.霍山石斛多糖对结肠癌荷瘤小鼠的抑瘤作用研究[D].合肥:合肥工业大学,2021.
[93]邓增华.益生元对小鼠肺腺癌影响的研究[D].天津:天津医科大学,2016.
[94]王丽敏.多糖和生酮饮食联用抗肿瘤活性研究[D].贵阳:贵州大学,2019.
[95]Huang JM,Liu D,Wang YW,et al.Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio,potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy[J].Gut,2022,71(4):734-745.
[96]张圣方.泰山蛹虫草多糖对免疫抑制小鼠肠道菌群和免疫调节功能的影响研究[D].泰安:山东农业大学,2015.
[97]孙豪.玉屏风多糖合生元对獭兔免疫功能和肠道菌群结构的影响[D].雅安:四川农业大学,2016.
[98]沈红,伍城颖,龙芳,等.从肠道菌群调控角度探讨中药汤剂中多糖组分存在的意义[J/OL].药学学报:1-17[2022-09-24].DOI:10.16438/j.0513-4870.2022-0861.

相似文献/References:

[1]余 勃,许　鹏.加味沙参麦冬汤治疗肺癌患者ＥＧＦＲ － ＴＫＩｓ相关皮疹的临床研究[J].陕西中医药大学学报,2019,(03):112.[doi:10.13424/j.cnki.jsctcm.2019.03.029]
　Yu Bo Xu Peng.Clinical Study on Modified Shashen Maidong Decoction in Treating EGFR - TKIs Related Rash in Patients with Lung Cancer[J].Journal of Shaanxi University of Traditional Chinese Medicine,2019,(02):112.[doi:10.13424/j.cnki.jsctcm.2019.03.029]
[2]王留晏 陈露 张克克.肺癌从脾肾论治体悟[J].陕西中医药大学学报,2019,(01):040.[doi:10.13424/j.cnki.jsctcm.2019.01.014]
[3]李宜鲜 魏华琳??.山豆根乙醇提取物对 Lewis 肺癌小鼠的抗肿瘤作用[J].陕西中医药大学学报,2021,44(03):086.[doi:10.13424/j.cnki.jsctcm.2021.03.019]
[4]刘文娟,乐世俊 姬玉洁 曹蔚 唐于平.中药多糖调节肠道菌群治疗2型糖尿病研究进展[J].陕西中医药大学学报,2023,(02):036.[doi:10.13424/j.cnki.jsctcm.2023.02.006 ]
　LIU Wenjuan YUE Shijun JI Yujie CAO Wei TANG Yuping.Research Progress in Treatment of Type 2 Diabetes by Regulating Intestinal Flora with Polysaccharide of Chinese Medicine[J].Journal of Shaanxi University of Traditional Chinese Medicine,2023,(02):036.[doi:10.13424/j.cnki.jsctcm.2023.02.006 ]

备注/Memo

备注/Memo:
基金项目：国家自然科学基金项目（82003653）;陕西省自然科学基金项目（2021JQ-734）;陕西中医药大学校级课题（2020XG01）
更新日期/Last Update: 2023-03-27