参考文献/References:
［1］吴才宏.2004年度诺贝尔生理学和医学奖简介［J］.生物化学与生物物理进展,2004,31(11):979-981.
［2］林依人,张彪.芳香类中药吸嗅疗法改善认知功能障碍研究进展［J］.江苏中医药,2017,49(9):78-81.
［3］李慧婷,李远辉,任桂林,等.中药挥发油防治情志疾病的研究现状及前景展望［J］.中草药,2019,50(17):4031-4040.
［4］Zhang YL,Long Y,Yu S,et al.Natural volatile oils derived from herbal medicines:a promising therapy way for treating depressive disorder［J］.Pharmacological Research,2021,164:105376.
［5］Fan WT,Wang Q.Mechanism of Acori Tatarinowii RhizomaCurcumae Radix treating depression based on network pharmacology［J］.Zhongguo Zhong Yao Za Zhi,2018,43(12):2607-2611.
［6］李冀,李想,高彦宇,等.中药石菖蒲研究进展［J］.辽宁中医药大学学报,2019,21(10):13-17.
［7］高学敏.中药学［M］.2版.北京:中国中医药出版社,2007:420-421.
［8］Chellian R,Pandy V,Mohamed Z.Pharmacology and toxicology of α- and β-Asarone:a review of preclinical evidence［J］.Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2017,32:41-58.
［9］王联生,潘菊华.石菖蒲治疗抑郁症的研究进展［J］.环球中医药,2017,10(4):509-512.
［10］郭美彤,赵佳奇,韩诚,等.石菖蒲药效物质基础和作用机制研究进展［J］.中药药理与临床,2019,35(2):179-184.
［11］邰佳,邹俊波,史亚军,等.GC-MS分析水蒸气蒸馏法提取石菖蒲挥发油过程中油水分配规律［J］.中草药,2020,51(1):59-66.
［12］魏刚,林双峰,方永奇,等.GC-MS建立石菖蒲挥发油质量标准研究［J］.中国中药杂志,2005,30(10):794-796.
［13］章晓娟,石书婷,易伦朝.四川产石菖蒲的挥发性成分色谱指纹图谱研究［J］.中华中医药杂志,2016,31(2):459-462.
［14］Han P,Han T,Peng W,et al.Antidepressantlike effects of essential oil and asarone,a major essential oil component from the rhizome of Acorus tatarinowii［J］.Pharmaceutical Biology,2013,51(5):589-594.
［15］唐怡,任刚,黄群,等.石菖蒲挥发油化学成分的GC-MS分析［J］.江西中医药,2014,45(12):60-62.
［16］杨鹤年,吴宿慧,李寒冰,等.石菖蒲的研究进展及质量标志物预测分析［J］.中国新药杂志,2021,30(13):1213-1219.
［17］张铁军,白钢,刘昌孝.中药质量标志物的概念、核心理论与研究方法［J］.药学学报,2019,54(2):187-196.
［18］徐飞飞,李钦青,楚世峰,等.石菖蒲挥发油中主要成分α-和β-细辛醚的神经药理学作用及机制研究进展［J］.天然产物研究与开发,2020,32(11):1969-1979.
［19］Lam KYC,Wu QY,Hu WH,et al.Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes［J］.Neuroscience Letters,2019,707:134308.
［20］王婉卿,王雷,王伟.石菖蒲挥发油对小鼠记忆障碍的作用及急性毒理研究［J］.药学研究,2019,38(2):76-79,124.
［21］李芝明,付胜奇,刘变化,等.石菖蒲通过CXCR4-PI3K信号通路对脑出血大鼠小胶质细胞自噬的影响［J］.中医学报,2021,36(8):1711-1717.
［22］林慧光,杜建,张亮亮,等.石菖蒲挥发油香熏辅助治疗老年性痴呆大鼠的实验研究［J］.福建中医学院学报,2007,17(4):25-27.
［23］吴慧,吴闻哲.经鼻给药增加药物脑靶向的制剂方法［J］.世界临床药物,2015,36(1):50-55.
［24］刘建春,杨婉芳,季新燕,等.中药鼻腔给药的脑靶向性探讨［J］.中医杂志,2014,55(15):1284-1287.
［25］胡泓博,夏传余,李光武.丁香酚吸嗅对MCAO模型大鼠脑源性神经营养因子的影响［J］.中风与神经疾病杂志,2015,32(1):28-32.
［26］杨天鹏,唐敏,刘巧琼,等.丁香酚通过嗅觉通路改善昆明鼠学习记忆的机制［J］.中国康复医学杂志,2007,22(6):487-489,508,478.
［27］陆燕,刘华,王东兴.中药鼻腔给药的临床前研究进展［J］.中国药房,2011,22(47):4500-4502.
［28］Chellian R,Pandy V,Mohamed Z.Alphaasarone attenuates depressionlike behavior in nicotinewithdrawn mice:Evidence for the modulation of hippocampal pCREB levels during nicotinewithdrawal［J］.European Journal of Pharmacology,2018,818:10-16.
［29］Chellian R,Pandy V,Mohamed Z.Biphasic effects of α-asarone on immobility in the tail suspension test:evidence for the involvement of the noradrenergic and serotonergic systems in its antidepressantlike activity［J］.Frontiers in Pharmacology,2016,7:72.
［30］Dong HY,Gao ZY,Rong H,et al.Β-asarone reverses chronic unpredictable mild stressinduced depressionlike behavior and promotes hippocampal neurogenesis in rats［J］.Molecules(Basel,Switzerland),2014,19(5):5634-5649.
［31］朱彩霞,黄丽,方永奇,等.β-细辛醚对慢性不可预见性轻度刺激小鼠模型的行为学和单胺类神经递质的影响［J］.时珍国医国药,2017,28(4):833-836.
［32］Xue ZF,Guo YL,Zhang S,et al.Betaasarone attenuates amyloid betainduced autophagy via Akt/mTOR pathway in PC12 cells［J］.European Journal of Pharmacology,2014,741:195-204.
［33］Li QQ,Xu FF,Zhang Q,et al.Effect of α-asarone on ethanolinduced learning and memory impairment in mice and its underlying mechanism［J］.Life Sciences,2019,238:116898.
［34］马宇昕,李国营,刘靖,等.β-细辛醚对阿尔茨海默病大鼠海马神经元突触可塑性的影响［J］.广东医学,2017,38(10):1489-1492.
［35］Zhang S,Gui XH,Huang LP,et al.Neuroprotective Effects of β-Asarone Against 6-Hydroxy DopamineInduced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway［J］.Molecular neurobiology,United States:2016,53(1):83-94.
［36］Kim BW,Koppula S,Kumar H,et al.Α-Asarone attenuates microgliamediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTPinduced behavioral deficits in a mouse model of Parkinson’s disease［J］.Neuropharmacology,2015,97:46-57.
［37］Huang LP,Deng MZ,Zhang S,et al.Coadministration of β-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa:a different mechanism from Madopar［J］.Clinical and Experimental Pharmacology & Physiology,2014,41(9):685-690.
［38］傅思莹,方若鸣,方更利,等.β-细辛醚对青霉素点燃癫痫大鼠额叶皮质FOS、GAD65表达的影响［J］.中药材,2008,31(1):79-81.
［39］傅思莹,杨国柱,李翎,等.β-细辛醚对癫痫大鼠氨基酸递质受体表达的影响［J］.中药材,2014,37(10):1837-1840.
［40］Huang C,Li WG,Zhang XB,et al.Α-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABA receptors［J］.Neuropharmacology,2013,65:1-11.
［41］方永奇,李翎,吴启端,等.β-细辛醚和冰片对大鼠缺血再灌注脑损伤的保护作用［J］.中国中医药科技,2004,11(6):353-354.
［42］Yang YX,Chen YT,Zhou XJ,et al.Betaasarone,a major component of Acorus tatarinowii Schott,attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats［J］.BMC Complementary and Alternative Medicine,2013,13:236.