[1]王曼莉 孙志广.胃肠苦味受体与胃肠动力相关性的研究进展[J].陕西中医药大学学报,2022,(02):132-136.[doi:10.13424/j.cnki.jsctcm.2022.02.029]
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胃肠苦味受体与胃肠动力相关性的研究进展
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2022年02期
页码:
132-136
栏目:
出版日期:
2022-04-16

文章信息/Info

文章编号:
2096-1340(2022)02-0132-05
作者:
王曼莉1 孙志广2
1.南京中医药大学第二附属医院，江苏 南京 210000；
2.南京中医药大学，江苏 南京 210000
关键词:
关键词：苦味受体; 胃肠动力; 胃肠激素; 苦味中药; 中药药性理论
分类号:
R284
DOI:
10.13424/j.cnki.jsctcm.2022.02.029
文献标志码:
A
摘要:
摘 要：苦味受体（Bitter taste receptor，TAS2R）是一类能够感受苦味觉的G-蛋白偶联受体（GPCR），在口腔、肠道、气道、尿道、血管平滑肌、神经系统、甲状腺等多处表达。通过回顾近年来国内外报道的胃肠道TAS2Rs与胃肠平滑肌收缩、胃肠激素之间的关系，认为不同的TAS2R根据表达部位和配体的不同而发挥不同的功能，胃肠苦味受体激活后，可以影响胃肠平滑肌的收缩、胃肠激素的释放、胃酸的分泌等，从而发挥影响胃排空、调整胃肠道运动、调节血糖稳态、影响机体代谢的作用。而在中医药中，苦味中药亦在消化系统疾病发挥着不可替代的作用，苦降辛开、苦辛通降等方法迄今仍是胃肠道疾病的常用治法，文章对苦味中药以TAS2R作为靶点治疗胃肠疾病提出设想。

参考文献/References:

［1］Depoortere I.Taste receptors of the gut:emerging roles in health and disease［J］.Gut,2014,63(1):179-190.
［2］Lee RJ,Kofonow JM,Rosen PL,et al.Bitter and sweet taste receptors regulate human upper respiratory innate immunity［J］.The Journal of Clinical Investigation,2014,124(3):1393-1405.
［3］Deckmann K,KrastevaChrist G,Rafiq A,et al.Cholinergic urethral brush cells are widespread throughout placental mammals［J］.International Immunopharmacology,2015,29(1):51-56.
［4］Liu X,Gu F,Jiang L,et al.Expression of bitter taste receptor Tas2r105 in mouse kidney［J］.Biochemical and Biophysical Research Communications,2015,458(4):733-738.
［5］Lund TC,Kobs AJ,Kramer A,et al.Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression［J］.PLoS One,2013,8(3):e58945.
［6］Voigt A,Bojahr J,Narukawa M,et al.Transsynaptic tracing from taste receptor cells reveals local tastereceptor gene expression in gustatory Ganglia and brain［J］.The Journal of Neuroscience:the Official Journal of the Society for Neuroscience,2015,35(26):9717-9729.
［7］Clark AA,Dotson CD,Elson AE,et al.TAS2R bitter taste receptors regulate thyroid function［J］.FASEB Journal,2015,29(1):164-172.
［8］Devillier P,Naline E,GrassinDelyle S.The pharmacology of bitter taste receptors and their role in human airways［J］.Pharmacology & Therapeutics,2015,155:11-21.
［9］Harada Y,Koseki J,Sekine H,et al.Role of bitter taste receptors in regulating gastric accommodation in Guinea pigs［J］.The Journal of Pharmacology and Experimental Therapeutics,2019,369(3):466-472.
［10］Avau B,Rotondo A,Thijs T,et al.Targeting extraoral bitter taste receptors modulates gastrointestinal motility with effects on satiation［J］.Scientific Reports,2015,5:15985.
［11］Janssen S,Laermans J,Verhulst PJ,et al.Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying［J］.Proceedings of the National Academy of Sciences of the United States of America,2011,108(5):2094-2099.
［12］李俊川,姜淮芜.胆囊收缩素临床研究进展［J］.现代医药卫生,2012,28(3):407-408.
［13］Yoshida R,Shin M,Yasumatsu K,et al.The role of cholecystokinin in peripheral taste signaling inmice［J］.Frontiers in Physiology,2017,8:866.
［14］GrauBové C,MiguénsGómez A,GonzálezQuilen C,et al.Modulation of food intake by differential TAS2R stimulation in rat［J］.Nutrients,2020,12(12):E3784.
［15］Andreozzi P,Sarnelli G,Pesce M,et al.The bitter taste receptor agonist quinine reduces calorie intake and increases the postprandial release of cholecystokinin in healthy subjects［J］.Journal of Neurogastroenterology and Motility,2015,21(4):511-519.
［16］Yamazaki T,Takahashi C,Taniguchi Y,et al.Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells［J］.Biochemical and Biophysical Research Communications,2020,533(4):704-709.
［17］Jeon TI,Seo YK,Osborne TF.Gut bitter taste receptorsignalling induces ABCB1 through a mechanism involving CCK［J］.The Biochemical Journal,2011,438(1):33-37.
［18］Singaram K,GoldSmith FD,Petrov MS.Motilin:a panoply of communications between the gut,brain,and pancreas［J］.Expert Review of Gastroenterology & Hepatology,2020,14(2):103-111.
［19］Deloose E,Corsetti M,Van Oudenhove L,et al.Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers［J］.Neurogastroenterology & Motility,2018,30(1):e13171.
［20］张乐,白洁.胰高血糖素样肽1在药物成瘾中的作用及机制［J］.中国药理学通报,2020,36(4):488-491.
［21］Kim KS,Egan JM,Jang HJ.Denatonium induces secretion of glucagonlike peptide1 through activation of bitter taste receptor pathways［J］.Diabetologia,2014,57(10):2117-2125.
［22］Park J,Kim KS,Kim KH,et al.GLP1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell［J］.Biochemical and Biophysical Research Communications,2015,468(1/2):306-311.
［23］Pham H,Hui HX,Morvaridi S,et al.A bitter pill for type 2 diabetes?The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells［J］.Biochemical and Biophysical Research Communications,2016,475(3):295-300.
［24］Huang J,Wang XL,Zhang YD.Specific types of alcoholic beverage consumption and risk of type 2 diabetes:a systematic review and meta-analysis［J］.Journal of Diabetes Investigation,2017,8(1):56-68.
［25］Kok BP,Galmozzi A,Littlejohn NK,et al.Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits［J］.Molecular Metabolism,2018,16:76-87.
［26］Yu YL,Liu L,Wang XT,et al.Modulation of glucagonlike peptide1 release by berberine:in vivo and in vitro studies［J］.Biochemical Pharmacology,2010,79(7):1000-1006.
［27］Yu YL,Hao G,Zhang QY,et al.Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways［J］.Biochemical Pharmacology,2015,97(2):173-177.
［28］Chou WL.Therapeutic potential of targeting intestinal bitter taste receptors in diabetes associated with dyslipidemia［J］.Pharmacological Research,2021,170:105693.
［29］Li JY,Xu J,Hou RF,et al.QingHua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice［J］.Biomedecine & Pharmacotherapie,2017,89:10-17.
［30］Tack J,Depoortere I,Bisschops R,et al.Influence of ghrelin on interdigestive gastrointestinal motility in humans［J］.Gut,2006,55(3):327-333.
［31］Avau B,Carbone F,Tack J,et al.Ghrelin signaling in the gut,its physiological properties,and therapeutic potential［J］.Neurogastroenterology & Motility,2013,25(9):720-732.
［32］Hao SZ,Sternini C,Raybould HE.Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastricadministration of bitter taste receptor ligands［J］.American Journal of Physiology Regulatory,Integrative and Comparative Physiology,2008,294(1):R33-R38.
［33］Behrens M,Gu M,Fan SJ,et al.Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors［J］.Chemical Biology & Drug Design,2018,91(2):422-433.
［34］Yue X,Liang J,Gu F,et al.Berberine activates bitter taste responses of enteroendocrine STC1 cells［J］.Molecular and Cellular Biochemistry,2018,447(1/2):21-32.
［35］杨超.基于现代文献对中医药治疗功能性消化不良诊治规律的研究［D］.南京:南京中医药大学,2018.
［36］祝捷,李宇航,王庆国,等.半夏泻心汤对功能性消化不良大鼠胃排空及血浆胃动素的影响［J］.中华中医药杂志,2005,20(6):335-337.
［37］沈天华,沈洪,吴坚,等.半夏泻心汤对功能性消化不良大鼠模型血浆P物质及胃窦黏膜CGRP的影响［J］.中华中医药杂志,2011,26(11):2737-2739.
［38］吴坚,张星星,沈洪.半夏泻心汤对功能性消化不良大鼠胃排空率和胃窦组织Ghrelin的影响［J］.四川中医,2014,32(1):70-72.
［39］Turner A,Veysey M,Keely S,et al.Interactions between bitter taste,diet and dysbiosis:consequences for appetite and obesity［J］.Nutrients,2018,10(10):E1336.
［40］Tran HTT,Herz C,Ruf P,et al.Human T2R38 bitter taste receptor expression in resting and activated lymphocytes［J］.Frontiers in Immunology,2018,9:2949.

备注/Memo

备注/Memo:
基金项目：国家自然科学基金项目（82074312）
更新日期/Last Update: 2022-04-06