[1]刘莎 朱晓娜 杨志宏 任鑫睿 王昕.调脂柔脉颗粒治疗高脂血症大鼠的实验研究[J].陕西中医药大学学报,2022,(02):067-70.[doi:10.13424/j.cnki.jsctcm.2022.02.015]
 LIU Sha ZHU Xiaona YANG Zhihong REN Xinrui WANG Xin.Experimental Study on Tiaozhi Roumai Granule in Treatment of Hyperlipidemia Rats[J].Journal of Shaanxi University of Traditional Chinese Medicine,2022,(02):067-70.[doi:10.13424/j.cnki.jsctcm.2022.02.015]
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调脂柔脉颗粒治疗高脂血症大鼠的实验研究
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2022年02期
页码:
067-70
栏目:
出版日期:
2022-04-16

文章信息/Info

Title:
Experimental Study on Tiaozhi Roumai Granule in Treatment of Hyperlipidemia Rats
文章编号:
2096-1340(2022)02-0067-05
作者:
刘莎1 朱晓娜2 杨志宏2 任鑫睿1 王昕1
1.陕西中医药大学,陕西 咸阳 712000;
2.陕西中医药大学附属医院,陕西 咸阳 712000
Author(s):
LIU Sha1 ZHU Xiaona 2YANG Zhihong2 REN Xinrui1 WANG Xin1
1.Shaanxi University ofTraditional Chinese Medicine,Shaanxi Xianyang 712000,China;2.Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Shaanxi Xianyang 712000,China
关键词:
关键词:调脂柔脉颗粒高脂血症动脉粥样硬化实验研究大鼠
Keywords:
Key words: Tiaozhi Roumai granuleHyperlipidemiaAtherosclerosisExperimental researchRat
分类号:
R285.5
DOI:
10.13424/j.cnki.jsctcm.2022.02.015
文献标志码:
A
摘要:
摘 要:目的 探讨调脂柔脉颗粒对高脂血症大鼠血脂以及颈部血管形态学的影响。方法 将72只SPF大鼠随机分为空白组(普通饲料喂养)、模型组、调脂柔脉低、中、高剂量组以及西药辛伐他汀组(高脂饲料喂养),造模8 W建立高脂血症大鼠模型,给予相应药物灌胃治疗。灌胃结束后取大鼠血清以及颈部血管,用全自动生化分析仪检测甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(LDLC),用HE染色方法观察颈部血管病理组织变化情况。结果 调脂柔脉低、中、高组以及辛伐他汀组在TC、TG、LDLC上显著低于模型组(P<0.05),HDLC高于模型组(P>0.05);颈部血管HE染色结果显示:调脂柔脉各剂量组以及辛伐他汀组在颈部血管的光滑度、厚度、平滑肌排列整齐度上与模型组比较病变情况均有不同程度改善。结论 调脂柔脉颗粒可以通过调节大鼠脂质代谢过程,改善颈部斑块情况,从而发挥抗动脉粥样硬化(atherosclerosis,AS)作用。
Abstract:
Abstract: Objective To investigate the effects of Tiaozhi Roumai granule on blood lipid and neck vascular morphology in hyperlipidemia rats.Methods 72 SPF Rats were randomly divided into blank group (fed with ordinary diet),model group,low,medium and high dose groups of Tiaozhi Roumai and Western medicine simvastatin group (fed with high-fat diet).The hyperlipidemia rat model was established after 8 weeks,and the corresponding drugs were given by gavage.After gavage,the serum and neck blood vessels of rats were taken.Triglyceride (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were detected by automatic biochemical analyzer.The pathological changes of neck blood vessels were observed by HE staining.Results TC,TG and LDL-C in Tiaozhi Roumai low,medium and high groups and simvastatin group were significantly lower than those in model group (P<0.05),and HDL-C was higher than those in model group (P>0.05);The results of HE staining of cervical blood vessels showed that the smoothness,thickness and smooth muscle arrangement of cervical blood vessels in each dose group and simvastatin group were improved in varying degrees compared with the model group.Conclusion Tiaozhi Roumai granule can improve the condition of cervical plaque by regulating the process of lipid metabolism in rats,so as to play the role of anti atherosclerosis (AS).

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备注/Memo

备注/Memo:
基金项目:咸阳市科技局项目(2018K0287)
更新日期/Last Update: 2022-04-06