[1]朱文新吴云虎?? 李良勇 裴培.星蒌承气汤治疗痰热腑实型卒中相关性肺炎 临床研究?[J].陕西中医药大学学报,2021,44(03):097-101.[doi:10. 13424 / j. cnki. jsctcm. 2021. 03. 021]
 ZHU Wenxin WU Yunhu LI LiangyongPEI Pei.Clinical Effects of Xinglou Chengqi Decoction on Stroke Associated Pneumonia of Phlegm Heat and Fu Excess Type[J].Journal of Shaanxi University of Traditional Chinese Medicine,2021,44(03):097-101.[doi:10. 13424 / j. cnki. jsctcm. 2021. 03. 021]
点击复制

星蒌承气汤治疗痰热腑实型卒中相关性肺炎 临床研究?
分享到:

《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
44
期数:
2021年03期
页码:
097-101
栏目:
论著
出版日期:
2021-05-30

文章信息/Info

Title:
Clinical Effects of Xinglou Chengqi Decoction on Stroke Associated Pneumonia of Phlegm Heat and Fu Excess Type
文章编号:
2096-1340(2021)03-0097-05
作者:
朱文新1吴云虎2?? 李良勇2 裴培2
1. 安徽中医药大学,安徽 合肥 230038;
2. 安徽中医药大学第一附属医院,安徽 合肥 230031
Author(s):
ZHU Wenxin1 WU Yunhu2 LI Liangyong2PEI Pei3
1. Anhui University of Traditional Chinese Medicine, Hefei 230038,China;
2. The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031,China
关键词:
卒中相关性肺炎痰热腑实证星蒌承气汤神经功能临床研究
Keywords:
Stroke associated pneumonia Phlegm heat Fu excess syndrome Xinglou Chengqi Decoction Neurologi- cal function Clinical research
分类号:
R256. 14
DOI:
10. 13424 / j. cnki. jsctcm. 2021. 03. 021
文献标志码:
A
摘要:
目的 观察星蒌承气汤治疗痰热腑实型卒中相关性肺炎(stroke-associated pneumonia,SAP)的临床应 用价值。 方法 将 60 例痰热腑实型 SAP 患者随机分为两组,每组各 30 例。 对照组予以常规基础治疗,治疗组予 以常规联合中药星蒌承气汤口服或者鼻饲,疗程为 2 w。 比较两组患者临床疗效、神经功能评分及日常生活能 力评分。 结果 治疗结果显示,两组治疗均有临床疗效,且治疗组总有效率高于对照组( p < 0. 05);治疗后两组 NIHSS 评分均低于治疗前,mRS 评分均高于治疗前,均为治疗组改变明显,差异有统计学意义( p < 0. 05)。 结论 在常规治疗的基础上联合星蒌承气汤治疗痰热腑实型 SAP 患者临床疗效显著,可明显缓解患者的呼吸系 统症状,改善神经功能,提高生活质量,值得临床推广。
Abstract:
Objective To observe the clinical application value of Xinglou Chengqi Decoction in the treatment of stroke associated pneumonia (SAP) of phlegm heat Fu excess type. Methods 60 patients with SAP of phlegm heat Fu ex- cess type were randomly divided into two groups, 30 cases in each group. The control group was given routine basic treat- ment, the treatment group was given routine combined with Xinglou Chengqi Decoction oral or nasal feeding, the course of treatment was 2 weeks. The clinical efficacy, neurological function score and ADL score were compared between the two groups. Results The treatment results showed that the two groups had clinical efficacy, and the total effective rate of the treatment group was higher than that of the control group (p < 0. 05); after treatment, the NIHSS scores of the two groups were lower than those before treatment, and the mRS scores were higher than those before treatment, which indicated that the treatment group had obvious changes, and the difference was statistically significant (p < 0. 05). Conclusion On the basis of conventional treatment combined with Xinglou Chengqi Decoction in the treatment of SAP patients with phlegmheat and Fu excess syndrome, the clinical effect is significant, which can significantly relieve the respiratory symptoms, improve the neurological function and improve the quality of life of patients, which is worthy of clinical promotion.

参考文献/References:

[1] HILKER R,POETTER C,FINDEISEN N,et al. Nosocomi- al pneumonia after acute stroke:implications for neurologi- cal inten - sive care medicine [ J] Stroke,2003,34(4): 975-981.
[2] TEH W H,SMITH C J,BARLAS R S,et al. Impact of stroke - associated pneumonia on mortality,length of hos- pitalization, and functional outcome [ J ]. Acta Neurol Scand,2018,138(4):293-300.
[3] YU Y J,WENG W C,SU F C,et al. Association between pneumonia in acute stroke stage and 3 - year mortality in patients with acute first - ever ischemic stroke[J/ OL]. J Clin Neurosci,2016,33:124-128.
[4] JI R,SHEN H,PAN Y,et al. Novel risk score to predict pneumonia after acute ischemic stroke[J]. Stroke,2013, 44(5):1303-1309.
[5]中国卒中学会急救医学分会. 卒中相关性肺炎诊治中 国专家共识[J]. 中国卒中杂志,2019, 14(12):1251.
[6]崔颖. 老年急性缺血性卒中相关性肺炎的易患因素及 其对 预 后 的 影 响 [ J]. 浙 江 医 学, 2017, 39 ( 13 ) : 1116-1117.
[7]宋苹,张溪,姚怀国. 卒中相关性肺炎的中医症状及证 型特征[J]. 实用医学杂志,2018,34(9):1557-1560.
[8]黄璐,张月娟,廖若夷,等. 中医药辅助治疗卒中相关性 肺炎的 Meta 分析[ J]. 湖南中医药大学学报,2016,36 (1):81-84.
[9]国家中医药管理局. 中医病证诊断疗效标准(中华人民 共和国中医药行业标准) [M]. 北京:中国医药科技出 版社, 2012:189-190.
[10]简文佳,时晶,田金洲. 王永炎先生运用化痰通腑法治 疗中风浅析[J]. 天津中医药,2015,32(2):65.
[11]王雪,吕晓佟,刘鑫,等. 卒中诱导的免疫抑制和卒中 相关性肺炎的研究进展[ J]. 中国实用神经疾病学杂 志,2018,21(15):1644-1647.
[12] Huang GQ,Lin YT,Wu YM,et al. Individualized Predic- tion Of Stroke - Associated Pneumonia For Patients With Acute Ischemic Stroke. Clin Interv Aging 2019; 14: 1951-1962.
[13] 张根明,星萎承气汤对缺血性中风痰热腑实证超敏 C - 反应蛋白的影响 [ J]. 光明中医, 2010, 25 ( 7 ) : 1129-1130.
[14]陈进玲,张丽蕊,陈艳霞,等. 星蒌承气汤对急性脑缺 血并发 SIRS 的治疗效果及对血清 TNF - α、D - L 水平 的影 响 [ J ]. 中 华 中 医 药 学 刊, 2018, 36 ( 11 ): 2729-2731.
[15]甄耀辉. 星蒌承气汤治疗急性期缺血性中风痰热腑实 证的临 床 观 察 [ J]. 中 医 临 床 研 究, 2017, 9 ( 22 ): 101-102.
[16]陈沛,江澜,韩笑,等. 星萎承气汤治疗急性缺血性中 风病痰热腑实证的临床观察〔 J]. 中华中医药杂志, 2018, 33 (10) : 4764-4767.
[17]和焕香,郭庆梅. 瓜蒌化学成分和药理作用研究进展 及质量标志物预测分析[ J]. 中草药,2019,50 (19): 4808-4820.
[18]黄玉秋,范亚楠,贾天柱,. 胆南星炮制现代研究进展 [J]. 医学研究杂志,2016,45(2):150-152.
[19]陈嘉倩,陈艳琰,唐于平,等. 大黄不同功效的古今用 药规律分析[J]. 中草药,2019,50(6):1485-1492.
[20]范敏,李晓波. 调胃承气汤的化学成分及药理作用研 究进展[J]. 中国药房,2016,27(31):4446-4448.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年基金项目(81803903)
更新日期/Last Update: 2021-06-08