[1]高斯１ 许鹏光１,２ 周鹏军１,２ 穆真１ 郭.梅花针叩刺联合 ＡＬＡ － ＰＤＴ 疗法对兔耳增生性瘢痕的抑制作用[J].陕西中医药大学学报,2019,(02):063-68.[doi:10.13424/j.cnki.jsctcm.2019.02.020]
　Gao Si,Xu Pengguang,Zhou Pengjun,et al.Inhibitory Effect of Pyonex Tapping Combined with ALA – PDT Therapy on Hypertrophic Scar in Rabbit Ears[J].Journal of Shaanxi University of Traditional Chinese Medicine,2019,(02):063-68.[doi:10.13424/j.cnki.jsctcm.2019.02.020]
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梅花针叩刺联合 ＡＬＡ － ＰＤＴ 疗法对兔耳增生性瘢痕的抑制作用()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2019年02期
页码:
063-68
栏目:
针推研究
出版日期:
2019-03-10

文章信息/Info

Title:
Inhibitory Effect of Pyonex Tapping Combined with ALA – PDT Therapy on Hypertrophic Scar in Rabbit Ears
文章编号:
2096-1340(2019)02-0063-06
作者:
高斯１ 许鹏光１; ２ 周鹏军１; ２ 穆真１ 郭
１． 陕西中医药大学，陕西 咸阳 712046；２． 陕西中医药大学附属医院，陕西 咸阳 712000
Author(s):
Gao Si 1 ;  Xu Pengguang 1;  2 ;  Zhou Pengjun 1;  2 ;  Mu Zhen 1 ;  Guo Min 1
1. Shaanxi University of Chinese Medicine, Xianyang China, 712046; 2. Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang China, 712000
关键词:
梅花针; ＡＬＡ － ＰＤＴ; 增生性瘢痕; 基质金属蛋白酶及其组织抑制剂; 兔耳实验
Keywords:
pyonex;  ALA - PDT;  hypertrophic scar;  matrix metalloproteinases and their tissue inhibitors;  rabbit ear experiment
分类号:
R245.3 R2 -031
DOI:
10.13424/j.cnki.jsctcm.2019.02.020
文献标志码:
A
摘要:
目的 研究梅花针叩刺联合 ＡＬＡ － ＰＤＴ 疗法对兔耳增生性瘢痕的疗效，探讨梅花针叩刺联合 ＡＬＡ －ＰＤＴ 疗法对兔耳增生性瘢痕的抑制作用。 方法 选取实验动物（日本大耳白家兔）分为正常组、阴性对照组、梅花针联合 ＡＬＡ － ＰＤＴ 治疗组、ＡＬＡ － ＰＤＴ 治疗组、ＰＤＴ 治疗组，对治疗组分别进行每周 １ 次，共 ３ 次的 ＰＤＴ 干预治疗，分别于治疗前行梅花针扣刺，分别于 ＰＤＴ 治疗后的 １ 月、２ 月、３ 月取样，进行 ＥＬＩＳＡ 实验及免疫组化。 结果梅花针叩刺联合 ＡＬＡ － ＰＤＴ 治疗后 １ 月、２ 月和 ３ 月其中的 ＭＭＰ － ２、ＭＭＰ － ９、ＭＭＰ － １３ 及 ＴＩＭＰ － １ 的蛋白浓度水平梅花针扣刺联合 ＡＬＡ － ＰＤＴ 治疗组与 ＡＬＡ － ＰＤＴ 治疗组之间蛋白表达水平比较有差异（ Ｐ ＜ ０． ０５）。结论 梅花针扣刺联合 ＡＬＡ － ＰＤＴ 治疗后可对兔耳增生性瘢痕起抑制作用。
Abstract:
Objective To study the curative effect of pyonex tapping combined with ALA - PDT therapy on hypertrophic scar in rabbit ears, and to explore its inhibitory effect on hypertrophic scar of rabbit ears. Method The experimental animals ( Japanese big ear white rabbits) were divided into normal group, negative control group, pyonex combined with ALA - PDT treatment group, ALA - PDT treatment group and PDT treatment group. The treatment group was treated with PDT intervention once a week for three times. The pyonex was pricked before each treatment. The samples were taken in January, February and March after PDT treatment for ELISA experiment and immunohistochemistry. Result The protein levels of MMP -2, MMP -9, MMP -13 and TIMP -1 in 1, 2 and 3 months after treatment with pyonex tapping combined with ALA - PDT were different between the pyonex combined with ALA - PDT group and the ALA - PDT group ( P <0. 05) . Conclusion Pyonex tapping combined with ALA - PDT can inhibit hypertrophic scar in rabbit ears.

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备注/Memo

备注/Memo:
收稿日期：２０１８－０４－０９ 编辑：巩振东）
更新日期/Last Update: 2019-03-15