[1]冯 智王 俊 李毅忠廖 超 唐学贵*.溃疡性结肠炎“血水同病”模型的建立及评价[J].陕西中医药大学学报,2018,(02):081-84.[doi::10.13424/j.cnki.jsctcm.2018.02.024]
 Feng Zhi.The Establishment and Evaluation of “Simultaneous Blood and Water Syndromes”Model of Ulcerative Colitis[J].Journal of Shaanxi University of Traditional Chinese Medicine,2018,(02):081-84.[doi::10.13424/j.cnki.jsctcm.2018.02.024]
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溃疡性结肠炎“血水同病”模型的建立及评价()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2018年02期
页码:
081-84
栏目:
实验研究
出版日期:
2018-03-10

文章信息/Info

Title:
The Establishment and Evaluation of “Simultaneous Blood and Water Syndromes”Model of Ulcerative Colitis
文章编号:
2096-1340(2018)02-0081-04
作者:
冯 智1王 俊 1 李毅忠1廖 超 1 唐学贵2*
1. 安康市中医医院,陕西 安康 725000; 2. 川北医学院附属医院,四川 南充 637000
Author(s):
Feng Zhi
1. Ankang Hospital of Chinese Medicine,Ankang 725000,China; 2. Affilicated Hospital of North Sichuan Medical College,Nanchong 637000,China )
关键词:
溃疡性结肠炎 血水同病 模型
Keywords:
UC simultaneous blood and water syndromes model
分类号:
R574. 62
DOI:
:10.13424/j.cnki.jsctcm.2018.02.024
文献标志码:
A
摘要:
建立符合中医证候特点的“血水同病”型溃疡性结肠炎( Ulcerative Colitis,UC) 大鼠模型。 方法 将 SD 雄性大鼠随机分为正常组、模型组。正常组给予普通喂养,模型组采用 TNBS 与乙醇复合物造模,观 察各组大鼠症状、体征、病理改变。结果 模型组大鼠造模后第 3 天开始出现不同程度的腹泻、粘液血便。造模 第 3 天模型组体重明显比正常组减少( P < 0. 05) ,大便隐血实验阳性,大鼠结肠粘膜轻度充血、水肿,肉眼损伤 评分与正常组比较,差异有统计学意义( P < 0. 05) 。模型组大鼠结肠粘膜病理检查见溃疡灶形成,腺体破坏,粘 膜及粘膜下层可见炎细胞浸润。结论 TNBS 与乙醇复合物建立血水同病型 UC 大鼠模型,符合人类自然发生的 UC 的病变特点和中医证候特点,是较理想的血水同病型 UC 模型。
Abstract:
To establish rat models of“simultaneous blood and water syndromes”of UC in line with the characteristics of TCM syndrome. Method: The male SD rats were randomly divided into normal group and model group. The normal group was given normal feeding,and the model group was built with TNBS and ethanol complex. The symp- toms,signs and pathological changes of the rats in each group were observed. Result: The rats in the model group began to show varying degrees of diarrhea and mucus bloody stool on the 3rd day after modeling,and the body weight of the mod- el group was significantly lower than that of the normal group ( P < 0. 05) . Stool occult blood test was positive. The colon- ic mucosa of rats was mild hyperemia and edema,and the score of naked eye injury was compared with that of the normal group,the difference was statistically significant ( P < 0. 05) . The pathological examination of the colon mucosa of the rats in the model group showed the formation of the ulcer,the destruction of the glands,and the infiltration of inflammato- ry cells in the mucosa and submucosa. Conclusion: The establish of rat models of “simultaneous blood and water syn- dromes”of UC with TNBS and ethanol complex is in line with the natural characteristics of human UC lesions and TCM syndromes,and is an ideal model of“simultaneous blood and water syndromes”of UC.

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备注/Memo

备注/Memo:
收稿日期: 2017 - 05 - 03 编辑:文颖娟
更新日期/Last Update: 2019-12-10