[1]王 涛** 康 涛 雷 琦 杨 谦 曹冰清**.银杏叶提取物注射液联合醒脑静注射液治疗阿尔茨海默病 70例[J].陕西中医药大学学报,2018,(02):030-33.[doi:10.13424/j.cnki.jsctcm.2018.02.010]
 Wang Tao,Kang Tao,Lei Qi,et al.70 Cases of the Treatment of Alzheimer's Disease by Ginkgo Leaf Extract Injection Combined with Xingnaojing Injection[J].Journal of Shaanxi University of Traditional Chinese Medicine,2018,(02):030-33.[doi:10.13424/j.cnki.jsctcm.2018.02.010]
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银杏叶提取物注射液联合醒脑静注射液治疗阿尔茨海默病 70例()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2018年02期
页码:
030-33
栏目:
临床研究
出版日期:
2018-03-10

文章信息/Info

Title:
70 Cases of the Treatment of Alzheimer's Disease by Ginkgo Leaf Extract Injection Combined with Xingnaojing Injection
文章编号:
2096-1340(2018)02-0030-05
作者:
王 涛** 康 涛 雷 琦 杨 谦 曹冰清**
陕西省人民医院,陕西 西安 710068)
Author(s):
Wang TaoKang TaoLei QiYang QianCao Bingqing
People's Hospital of Shaanxi Province,Xi'an 710068,China
关键词:
阿尔茨海默病 银杏叶提取物 醒脑静注射液 临床疗效
Keywords:
Alzheimer's disease ginkgo leaf extract Xingnaojing injection clinical effect
分类号:
R749. 1+6
DOI:
10.13424/j.cnki.jsctcm.2018.02.010
文献标志码:
A
摘要:
观察银杏叶提取物注射液联合醒脑静注射液治疗阿尔茨海默病的临床疗效。方法 将 140 例 阿尔茨海默病患者随机平均分为两组,对照组给予银杏叶提取物注射液,治疗组给予银杏叶提取物注射液联合 醒脑静注射液,其中银杏叶提取物注射液治疗方案同对照组。4 周后采用简易智能状态检查量表( MMSE) 、阿 尔茨海默病评估量表认知分量表( ADAS - cog) 、日常生活能力量表( ADL) 及脑电图( EEG) 评估治疗效果、脑电 异常率、P300 潜 伏 值 及 波 幅 变 化。结 果 治 疗 4 周 后,治 疗 组 总 有 效 率 高 于 对 照 组,差 异 有 统 计 学 意 义 ( P < 0. 05) ,治疗组在 MMSE、ADAS - cog 及 ADL 评分方面较对照组均有显著改善,其差异有统计学意义 ( P < 0. 05) 。治疗组脑电异常率也较对照组降低,P300 潜伏期较对照组明显缩短,且其波幅较对照组明显升高, 差异具有统计学意义( P < 0. 05) 。结论 银杏叶提取物注射液联合醒脑静注射液治疗阿尔茨海默病的临床疗效 较好,可有效改善患者认知功能。
Abstract:
To observe the clinical effect of ginkgo leaf extract injection combined with Xingnaojing injec- tion in treating Alzheimer's disease. Method: 140 cases of Alzheimer's disease were randomly divided into two groups, the control group was given ginkgo leaf extract injection,the treatment group was given ginkgo leaf extract injection and Xingnaojing injection,of which the therapeutic schedule of ginkgo leaf extract injection was the same as the control group. After 4 weeks,the therapeutic effect,EEG abnormality rate,P300 latency and amplitude changes were assessed byMMSE,ADAS - cog,ADL and EEG. Result: After 4 weeks of treatment,the total effective rate of the treatment group was higher than that of the control group,the difference was statistically significant ( P < 0. 05) . The MMSE,ADAS - cog and ADL scores of the treatment group were significantly improved compared with the control group with statistical sig- nificance ( P < 0. 05) . The EEG abnormality rate in the treatment group was also lower than that in the control group,the latency of P300 was significantly shorter than that in the control group,and the amplitude of the EEG was significantly higher than that in the control group,the difference was statistically significant ( P < 0. 05) . Conclusion: Ginkgo leaf ex- tract injection combined with Xingnaojing injection in the treatment of Alzheimer's disease has good clinical effect and can effectively improve the patients' cognitive function.

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备注/Memo

备注/Memo:
收稿日期: 2017 - 05 - 29 编辑:杨芳艳 * ** ***
基金项目:国家自然科学基金项目( 31100787) 作者简介:王涛( 1978 - ) ,男,博士,主治医师,主要研究方向: 脱髓鞘脑病,基因工程。E - mail: wangt78@ fmmu. edu. cn
通讯作者:曹冰清( 1984 - ) ,女,硕士,主治医师,主要研究方向: 帕金森病,阿尔茨海默病。E - mail: 569689538@ qq. com
更新日期/Last Update: 2019-12-10