[1]黄露露 姚庆华.中医药联合同步放化疗对鼻咽癌疗效影响的 Meta 分析[J].陕西中医药大学学报,2017,(03):092-99.[doi:10.13424/j.cnki.jsctcm.2017.03.030]
 Huang Lulu Yao Qinghua.Meta Analysis of the Effect of Traditional Chinese Medicine Combined with Concurrent Chemoradiotherapy on Nasopharyngeal Carcinoma[J].Journal of Shaanxi University of Traditional Chinese Medicine,2017,(03):092-99.[doi:10.13424/j.cnki.jsctcm.2017.03.030]
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中医药联合同步放化疗对鼻咽癌疗效影响的 Meta 分析()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2017年03期
页码:
092-99
栏目:
文献研究
出版日期:
2017-05-03

文章信息/Info

Title:
Meta Analysis of the Effect of Traditional Chinese Medicine Combined with Concurrent Chemoradiotherapy on Nasopharyngeal Carcinoma
文章编号:
2096-1340(2017)03-0092-08
作者:
黄露露 姚庆华
1. 浙江中医药大学第一临床医学院,浙江 杭州 310053; 2. 浙江省肿瘤医院,浙江省肿瘤医院中西医结合重点实验室, 浙江 杭州 310022
Author(s):
Huang Lulu1 Yao Qinghua2
1. The First Clinical Medical College of Zhenjiang University of Chinese Medicine, Hangzhou 310053, China; 2. The Key Laboratory of Integrative Chinese and Western Medicine, Tumor Hospital of Zhejiang Province, 310022, China
关键词:
中医药 鼻咽癌 Meta 分析
Keywords:
Chinese medicine nasopharyngeal carcinoma Meta analysis
分类号:
R739.63
DOI:
10.13424/j.cnki.jsctcm.2017.03.030
文献标志码:
A
摘要:
目的 系统评价中医药联合同步放化疗治疗鼻咽癌的疗效是否优于单纯放化疗治疗。方法 计算机 检索 MEDLINE、 EMbase、 SCI、 CBM、 CNKI、 VIP、 PubMed 等数据库,收集中医药联合放化疗治疗( 实验组) 与单纯放 化疗治疗鼻咽癌患者( 对照组) 疗效影响的随机对照试验( RCT) 。由 2 位评价者独立筛选文献、 提取资料和评价 纳入研究的偏倚风险后,采用 RevMan5. 1 软件进行 Meta 分析。结果 我们最终纳入 37 篇文献,其中包括 2023 例 实验组和 185
Abstract:
Objective: To comprehensively assess the curative effect of Chinese medicine combined with concurrent chemoradiotherapy on nasopharyngeal carcinoma to see whether the effect of combined method is superior to the simple chemoradiotherapy. Method: Retrieved from MEDLINE, EMbase, SCI, CBM, CNKI, VIP and PubMed database, the materials were collectecl to get a conclusion for randomized controlled trials ( RCTs) of the effect comparisons between the combining method ( the experimental group) and the simple chemoradiotherapy ( the control group) in treating nasopharyngeal carcinoma. The Meta analysis was conducted by two reviewers with RevMan5. 1 software who independently screened the literature, extracted data and evaluated risk of bias containing in the collected data. Results: Totally 37 articles were brought into the research, containing 2023 cases of experimental group and 1852 cases of control group. Resultsof Meta analysis indicated that Chinese medicine combined with radiotherapy and chemotherapy can improve the prognosis of patients with nasopharyngeal carcinoma. The prognosis more than 1 year: RR = 0. 48, 95% CI = 0. 38 - 0. 61, 16 cases of clinical research, experimental group / control group = 794 /761; the prognosis more than 3 years: RR = 0. 78, 95% CI = 0. 65 - 0. 94, 15 cases of clinical research, experimental group / control group = 819 /684; the prognosis more than 5 years: RR = 0. 84, 95% CI = 0. 76 - 0. 93, 10 cases of clinical research, experimental group / control group = 756 /673; all the difference showed statistical meaning. Meanwhile, it was showed that the tumor in the experimental group had a better overall effective rate ( total reactive rate = 1. 07, 95% CI = 1. 01 - 1. 14, 20 cases of clinical research, experimental group / control group = 914 /837) . Discussion: Whether in the short term or long term, curative effect of TCM combined with radiotherapy and chemotherapy in the treatment of nasopharyngeal carcinoma was better than chemotherapy. Limited by the methodological quality and sample’ s quantity in the collected literature, the achieved conclusion still needs to be verified with more high - qualified RCT.

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备注/Memo

备注/Memo:
收稿日期:2016-11-04编辑:杨芳艳
基金项目:国家自然科学基金项目(81673813)
通讯作者:姚庆华(1974-),女,主任医师,主要研究方向:中西医结合肿瘤方向。Email:danfer1001@163.com.
更新日期/Last Update: 2017-05-15