[1]关茜１ 焦俊?１ 叶子豪１ 王克穷２.益脾扶正方联合化疗治疗中晚期食管癌 ２１ 例[J].陕西中医药大学学报,2019,(01):150-154,158.[doi:10.13424/j.cnki.jsctcm.2019.01.045]
　Guan Qian Jiao Junzhe Ye Zihao Wang Keqiong.Clinical Analysis of Yipi Fuzheng Recipe combined with Chemotherapy in the Treatment of Advanced Esophageal Cancer[J].Journal of Shaanxi University of Traditional Chinese Medicine,2019,(01):150-154,158.[doi:10.13424/j.cnki.jsctcm.2019.01.045]
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益脾扶正方联合化疗治疗中晚期食管癌 ２１ 例()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2019年01期
页码:
150-154,158
栏目:
临床研究
出版日期:
2019-01-10

文章信息/Info

Title:
Clinical Analysis of Yipi Fuzheng Recipe combined with Chemotherapy in the Treatment of Advanced Esophageal Cancer
文章编号:
2096-1340(2019)01-0150-06
作者:
关茜１ 焦俊?１ 叶子豪１ 王克穷２
１． 陕西中医药大学第一临床医学院，陕西 咸阳 712046；２． 陕西中医药大学，陕西 咸阳 712000
Author(s):
Guan Qian 1 Jiao Junzhe 1 Ye Zihao 1 Wang Keqiong 2
1. Shaanxi University of Chinese Medicine, Xianyang China, 712046
关键词:
益脾扶正方; 化疗; 中晚期食管癌; 临床观察
Keywords:
Yipi Fuzheng Decoction;  chemotherapy;  advanced esophageal cancer;  clinical observation
分类号:
R735.1
DOI:
10.13424/j.cnki.jsctcm.2019.01.045
文献标志码:
A
摘要:
目的 观察益脾扶正方联合化疗治疗中晚期食管癌临床疗效。 方法 将 ４１ 例中晚期食管癌患者按照随机数字法分为治疗组 ２０ 例和对照组 ２１ 例。 对照组单用紫杉醇 ＋ 奈达铂化疗方案，治疗组在对照组基础上加用益脾扶正方，持续观察 ２ 周期，每周期 ２１ 天，观察治疗组和对照组患者治疗前后中医证候积分、免疫功能指标、ＫＰＳ 评分、化疗后毒副作用的发生率、近期疗效判定等指标并进行统计学评价。 结果 １． 在中医证候积分、中医证候疗效改善、ＫＰＳ 评分、免疫指标等方面，治疗组与对照组对比有统计学差异（Ｐ ＜ ０． ０５）２． 在减轻毒副作用方面，治疗组与对照组在治疗前后对比中，在改善恶心、呕吐症状具显著差异（Ｐ ＜ ０． ０５）。 ３． 在近期疗效方面，治疗组瘤体缓解有效率高于对照组，但两组间无统计学差异。 （Ｐ ＞ ０． ０５）。 结论 益脾扶正方联合化疗治疗中晚期食管癌可有效缓解患者临床症状，提高患者 ＫＰＳ 评分及生活质量，可有效降低恶心、呕吐等化疗副作用的发生率并改善患者免疫功能，为中西医结合治疗食管癌提供了优化方案。
Abstract:
To observe the clinical effect of Yipi Fuzheng Decoction combined with chemotherapy in the treatment of advanced esophageal cancer. Method: 41 patients with advanced esophageal cancer were randomly divided into treatment group ( 20 cases) and control group ( 21 cases) . The control group was treated with paclitaxel plus nedaplatin chemotherapy alone, while the treatment group was treated with Yipi Fuzheng Recipe on the basis of the control group. The two groups were observed for 2 cycles, 21 days a cycle. The scores of TCM syndromes, immune function, KPS score, incidence of toxic and side effects after chemotherapy, short - term efficacy evaluation and other indicators were observed before and after treatment in the treatment group and the control group, and the statistical evaluation was made. Result: 1. There were statistical differences between the treatment group and the control group in the aspects of TCM syndrome score, improvement of TCM syndrome efficacy, KPS score and immune index ( P < 0. 05) . 2. In alleviating toxic and side effects, there were significant differences between the treatment group and the control group in improving nausea and vomiting symptoms before and after treatment ( P < 0. 05) . 3. In terms of short - term efficacy, the effective rate of tumor remission in the treatment group was higher than that in the control group, but there was no statistical difference between the two groups. ( P > 0. 05) . Conclusion: Yipi Fuzheng Decoction combined with chemotherapy in the treatment of advanced esophageal cancer can effectively alleviate the clinical symptoms of patients, improve the KPSscore and quality of life of patients, effectively reduce the incidence of side effects such as nausea and vomiting, and improve the immune function of patients. It provides an optimized scheme for the treatment of esophageal cancer with integrated traditional Chinese and Western medicine.

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备注/Memo

备注/Memo:
基金项目：陕西省中医药管理局资助项目（ＬＣＰＴ０２０
更新日期/Last Update: 2019-01-15