[1]江欣 王亿平.中药足浴法联合吡贝地尔治疗透析患者不宁腿综合征临床研究[J].陕西中医药大学学报,2022,(04):095-100.[doi:10.13424/j.cnki.jsctcm.2022.04.021]
　JIANG Xin WANG Yiping.Clinical study of Treatment of Uremic Restless Legs Syndrome in Dialysis Patients with Chinese Medicine Foot Bath Combined with Piribedil[J].Journal of Shaanxi University of Traditional Chinese Medicine,2022,(04):095-100.[doi:10.13424/j.cnki.jsctcm.2022.04.021]
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中药足浴法联合吡贝地尔治疗透析患者不宁腿综合征临床研究
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2022年04期
页码:
095-100
栏目:
论著
出版日期:
2022-07-20

文章信息/Info

Title:
Clinical study of Treatment of Uremic Restless Legs Syndrome in Dialysis Patients with Chinese Medicine Foot Bath Combined with Piribedil
文章编号:
2096-1340(2022)04-0095-06
作者:
江欣1 王亿平2
1.安徽中医药大学，安徽 合肥 230038；
2.安徽中医药大学第一附属医院，安徽 合肥 230031
Author(s):
JIANG Xin1 WANG Yiping2
1.Anhui University of Traditional Chinese Medicine，Hefei 230038,China；
2.The First Affiliated Hospital of Anhui University of Traditional Chinese medicine，Hefei 230031,China
关键词:
关键词：中药足浴; 不宁腿综合征; 吡贝地尔; 透析; 睡眠质量
Keywords:
Key words：Chinese medicine foot bath; Restless legs syndrome; Piribedil; Dialysis; Sleep quality
分类号:
R459.5
DOI:
10.13424/j.cnki.jsctcm.2022.04.021
文献标志码:
A
摘要:
摘 要：目的 观察中药足浴法联合吡贝地尔治疗透析患者不宁腿综合征（uremic restless legs syndrome,uRLS）的临床疗效。方法 选取60例透析患者伴不宁腿综合征（包括血液透析和腹膜透析），随机将其分成治疗组（30例）与对照组（30例）。对照组予吡贝地尔50 mg睡前口服，治疗组在对照组的基础上同时进行中药足浴，疗程为4周。比较两组患者国际不宁腿综合征自评量表（IRLSSG）评分、匹兹堡睡眠质量指数（PSQI）评分及临床疗效，观察治疗期间药物的不良反应及血生化相关指标。结果 治疗组的总有效率为86.67%（26/30），对照组为60.00%（18/30），比较两组的有效率，差异显著（P＜0.05）；与治疗前相比，治疗组和对照组IRLSSG、PSQI均降低（P＜0.05），且治疗组较对照组降低更显著；两组血钙（Ca）、血磷（P）、甲状旁腺激素（iPTH）治疗前后无明显变化，两组间进行比较，差异不明显（P>0.05）；并对两组的不良反应发生率进行比较，差异无意义（P>005）。结论 中药足浴法联合吡贝地尔治疗透析患者伴不宁腿综合征的疗效较显著，可以明显缓解临床症状，改善睡眠质量。
Abstract:
Abstract：Objective To observe the clinical efficacy of Chinese medicine foot bath combined with piribedil in the treatment of uremic restless legs syndrome (u-RLS) in dialysis patients. Methods 60 dialysis patients with restless legs syndrome (including hemodialysis and peritoneal dialysis) were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was given piribedil 50 mg orally before going to bed，while the treatment group was given traditional Chinese medicine foot bath on the basis of the control group for 4 weeks. The scores of international restless legs syndrome self rating scale (IRLSSG)，Pittsburgh sleep quality index (PSQI) and clinical efficacy were compared between the two groups. The adverse reactions of drugs and related blood biochemical indexes were observed during the treatment. Results The total effective rate was 86.67% (26/30) in the treatment group and 60.00% (18/30) in the control group. There was significant difference between the two groups (P<0.05)；Compared with that before treatment，IRLSSG and PSQI in the treatment group and the control group decreased (P<0.05)，and the decrease in the treatment group was more significant than that in the control group；There were no significant changes in serum calcium (Ca)，serum phosphorus (P) and parathyroid hormone (iPTH) in the two groups before and after treatment. There was no significant difference between the two groups (P>0.05)；There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Traditional Chinese medicine foot bath combined with piribedil has a significant effect on dialysis patients with restless legs syndrome，which can significantly alleviate clinical symptoms and improve sleep quality. Abstract：Objective To observe the clinical efficacy of Chinese medicine foot bath combined with piribedil in the treatment of uremic restless legs syndrome (uRLS) in dialysis patients. Methods 60 dialysis patients with restless legs syndrome (including hemodialysis and peritoneal dialysis) were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was given piribedil 50 mg orally before going to bed，while the treatment group was given traditional Chinese medicine foot bath on the basis of the control group for 4 weeks. The scores of international restless legs syndrome self rating scale (IRLSSG)，Pittsburgh sleep quality index (PSQI) and clinical efficacy were compared between the two groups. The adverse reactions of drugs and related blood biochemical indexes were observed during the treatment. Results The total effective rate was 86.67% (26/30) in the treatment group and 60.00% (18/30) in the control group. There was significant difference between the two groups (P<0.05)；Compared with that before treatment，IRLSSG and PSQI in the treatment group and the control group decreased (P<0.05)，and the decrease in the treatment group was more significant than that in the control group；There were no significant changes in serum calcium (Ca)，serum phosphorus (P) and parathyroid hormone (iPTH) in the two groups before and after treatment. There was no significant difference between the two groups (P>0.05)；There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Traditional Chinese medicine foot bath combined with piribedil has a significant effect on dialysis patients with restless legs syndrome，which can significantly alleviate clinical symptoms and improve sleep quality. Abstract：Objective To observe the clinical efficacy of Chinese medicine foot bath combined with piribedil in the treatment of uremic restless legs syndrome (uRLS) in dialysis patients. Methods 60 dialysis patients with restless legs syndrome (including hemodialysis and peritoneal dialysis) were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was given piribedil 50 mg orally before going to bed，while the treatment group was given traditional Chinese medicine foot bath on the basis of the control group for 4 weeks. The scores of international restless legs syndrome self rating scale (IRLSSG)，Pittsburgh sleep quality index (PSQI) and clinical efficacy were compared between the two groups. The adverse reactions of drugs and related blood biochemical indexes were observed during the treatment. Results The total effective rate was 86.67% (26/30) in the treatment group and 60.00% (18/30) in the control group. There was significant difference between the two groups (P<0.05)；Compared with that before treatment，IRLSSG and PSQI in the treatment group and the control group decreased (P<0.05)，and the decrease in the treatment group was more significant than that in the control group；There were no significant changes in serum calcium (Ca)，serum phosphorus (P) and parathyroid hormone (iPTH) in the two groups before and after treatment. There was no significant difference between the two groups (P>0.05)；There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Traditional Chinese medicine foot bath combined with piribedil has a significant effect on dialysis patients with restless legs syndrome，which can significantly alleviate clinical symptoms and improve sleep quality.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金面上项目(81673931)；安徽中医药领军人才项目［中医药发展秘(2018)23号］
更新日期/Last Update: 2022-07-25