[1]刘德亮１ 楚淑芳１ 李惠林１ 赵恒侠１ 渠昕１ 周道成１ 曾霖２ 庄伟坤２ 张学文３.活血降糖饮对 ２ 型糖尿病患者饮食偏好的影响及分子机制研究[J].陕西中医药大学学报,2019,(01):119-122,133.[doi:10.13424/j.cnki.jsctcm.2019.01.036]
　Liu Deliang Chu Shufang Li Huilin Zhao Hengxia Qu Xin Zhou Daocheng Zeng Lin Zhuang Weikun Zhang Xuewen.Effect of Huoxue Jiangtang Decoction on Dietary Preference of Patients with Type 2 Diabetes and Its Molecular Mechanism[J].Journal of Shaanxi University of Traditional Chinese Medicine,2019,(01):119-122,133.[doi:10.13424/j.cnki.jsctcm.2019.01.036]
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活血降糖饮对 ２ 型糖尿病患者饮食偏好的影响及分子机制研究()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2019年01期
页码:
119-122,133
栏目:
临床研究
出版日期:
2019-01-10

文章信息/Info

Title:
Effect of Huoxue Jiangtang Decoction on Dietary Preference of Patients with Type 2 Diabetes and Its Molecular Mechanism
文章编号:
2096-1340(2019)01-0119-05
作者:
刘德亮１ 楚淑芳１ 李惠林１ 赵恒侠１ 渠昕１ 周道成１ 曾霖２ 庄伟坤２ 张学文３
１． 深圳市中医院，广东 深圳 518033； ２． 广州中医药大学第四临床医学院，广东 深圳 518033；３． 陕西中医药大学，陕西 咸阳 712046
Author(s):
Liu Deliang 1 Chu Shufang 1 Li Huilin 1 Zhao Hengxia 1 Qu Xin 1 Zhou Daocheng 1 Zeng Lin 2 Zhuang Weikun 2 Zhang Xuewen 3
1. Shenzhen TCM Hospital, Shenzhen China, 518033; 2. The Forth Clinical Medical School of Guangzhou University of Chinese Medicine, Shenzhen 518033; 3. Shaanxi University of Chinese Medicine, Xianyang China, 712046
关键词:
活血降糖饮; 饮食偏好; 可溶性 ＣＤ３６
Keywords:
Huoxue Jiangtang Decoction;  diet preference;  soluble CD36
分类号:
R587.1
DOI:
10.13424/j.cnki.jsctcm.2019.01.036
文献标志码:
A
摘要:
目的 探讨活血降糖饮对 ２ 型糖尿病患者高糖高脂饮食偏好的影响以及对血浆可溶性 ＣＤ３６ 的调控作用。 方法 选取我院住院及门诊患者共 ４０ 例，分为治疗组和对照组，各 ２０ 例，均给予磷酸西格列汀口服治疗，治疗组加用活血降糖饮。 治疗前后分别计算证候积分，检测空腹血糖（ＦＰＧ），餐后 ２ 小时血糖（２ｈ － ＰＧ），空腹胰岛素（ＦＩｎｓ），餐后 ２ 小时胰岛素（２ｈ － Ｉｎｓ），胰岛素抵抗指数（ＨＯＭＡ － ＩＲ），游离脂肪酸（ＦＦＡ），ｓＣＤ３６，以及对４ 种不同糖脂含量的饮品的偏好得分。 结果 经治疗，两组患者证候积分、ＦＰＧ、２ｈ － ＰＧ、Ｆｉｎｓ、２ｈ － Ｉｎｓ、ＨＯＭＡ －ＩＲ、ＦＦＡ、ｓＣＤ３６ 以及对高糖高脂饮食的偏好得分均明显改善（Ｐ ＜ ０． ０５，Ｐ ＜ ０． ０１）。 经治疗后，治疗组证候积分、２ｈ － ＰＧ、Ｆｉｎｓ、２ｈ － Ｉｎｓ、ＨＯＭＡ － ＩＲ、ＦＦＡ、ｓＣＤ３６ 以及对高糖高脂饮食的偏好得分均较对照组改善更加明显，差异有统计学意义（Ｐ ＜ ０． ０５，Ｐ ＜ ０． ０１）。 结论 活血降糖饮具有良好的降糖调脂改善胰岛素抵抗的作用，同时能够调节血浆 ｓＣＤ３６ 含量，并能够改善 ２ 型糖尿病患者对高糖高脂饮食的偏好。
Abstract:
To explore the effect of Huoxue Jiangtang Decoction on high glucose and high fat diet preference in patients with type 2 diabetes mellitus and its regulation on plasma soluble CD36. Method: A total of 40 inpatients and outpatients in our hospital were selected and divided into treatment group and control group, with 20 cases in each.All patients were given Sigliptin Phosphate Oral Treatment, and the treatment group was given Huoxue Jiangtang Decoction in addition. Syndrome scores were calculated, fasting blood glucose ( FPG) , 2 - hour postprandial blood glucose ( 2h- PG) , fasting insulin ( FIns) , 2 - hour postprandial insulin ( 2h - Ins) , insulin resistance index ( HOMA - IR) , freefatty acid ( FFA) , sCD36 and preference scores for four drinks with different glycolipid contents were measured before and after treatment. Result: After treatment, the scores of syndromes, FPG, 2h - PG, Fins, 2h - Ins, HOMA - IR, FFA,sCD36 and preference for high - sugar and high - fat diet were significantly improved in both groups ( P < 0. 05, P < 0.01) . After treatment, the scores of syndromes, 2h - PG, Fins, 2h - Ins, HOMA - IR, FFA, sCD36 and preference for high - sugar and high - fat diet in the treatment group improved more significantly than those in the control group, the difference was statistically significant ( P < 0. 05, P < 0. 01) . Conclusion: Huoxue Jiangtang Decoction has a good effect of lowering blood sugar and lipid, improving insulin resistance, regulating plasma sCD36 content, and improving the preference of type 2 diabetes mellitus for high - sugar and high - fat diet.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81704002);深圳市医疗卫生“三名工程”项目(SZSM201512043)
更新日期/Last Update: 2019-01-15