[1]赵艳莉 吴召利 李仁廷.扶正祛痰方联合顺铂对 LL/2 荷瘤小鼠非小细胞肺癌血清 IL - 2 水平的影响[J].陕西中医药大学学报,2017,(04):101-104.[doi:10.13424/j.cnki.jsctcm.2017.04.033]
 Zhao Yanli Wu zhaoli Li enting.The Effect of the Health - enhancing and Phlegm - removing Prescription Combined with Cisplatin on IL - 2 Levels in NSCLC Serum of Mice Bearing LL / 2 Neoplasm[J].Journal of Shaanxi University of Traditional Chinese Medicine,2017,(04):101-104.[doi:10.13424/j.cnki.jsctcm.2017.04.033]
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扶正祛痰方联合顺铂对 LL/2 荷瘤小鼠非小细胞肺癌血清 IL - 2 水平的影响()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2017年04期
页码:
101-104
栏目:
实验研究
出版日期:
2017-07-05

文章信息/Info

Title:
The Effect of the Health - enhancing and Phlegm - removing Prescription Combined with Cisplatin on IL - 2 Levels in NSCLC Serum of Mice Bearing LL / 2 Neoplasm
文章编号:
2096-1340(2017)04-0101-04
作者:
赵艳莉 吴召利 李仁廷
陕西中医药大学附属医院肿瘤一科,陕西 咸阳 712000
Author(s):
Zhao Yanli Wu zhaoli Li Renting
Oncology Department,the First Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China
关键词:
扶正祛痰方 顺铂 非小细胞肺癌
Keywords:
Health - enhancing and Phlegm - removing PrescriptioncisplatinNSCLC
分类号:
R734.2
DOI:
10.13424/j.cnki.jsctcm.2017.04.033
文献标志码:
A
摘要:
: 目的 观察扶正祛痰方、顺铂及扶正祛痰方与顺铂联合治疗非小细胞肺癌的疗效,探索扶正祛痰方 的抗癌机制及对顺铂的增效减毒作用。方法 将 40 只小鼠分为对照组、扶正祛痰方组、顺铂组和联合组,每组各 10 只小鼠。对照组给予常规喂养,扶正祛痰方组每天中药灌胃,顺铂组腹腔注射顺铂,每周两次,联合组结合上 述两种方法给药,所有小鼠 21 天后处死。小鼠处死前取血,采用 ELISA 法检测 IL - 2; 小鼠处死后,测肿瘤体积 及脾脏、胸腺重量。结果 扶正祛痰方组、顺铂组和联合组中的抑瘤率分别为 66. 9%
Abstract:
Objective: To observe the effect of Health - enhancing and Phlegm - removing Prescription,cisplatin as well as both combination on non - small cell lung cancer ( NSCLC) and to explore the anti - cancer mechanism of Health - enhancing and Phlegm - removing Prescription as well as the cisplatin’s action in enhancing the therapeutic effects and reducing poisonousness. Method: Totally 40 mice were evenly divided into the control,HPP ( Health - enhancing and Phlegm - removing Prescription) ,CS ( cisplatin) and combining group. The control group received conventional feeding,HPP group Chinese medicine lavage every day,CS group intraperitoneally injection of cisplatin for twice a week and the combining group was in combination of the above two methods,all mice put to death after 21 days. The mice were taken blood before executed to determine IL - 2 levels by ELISA method. After the mice were executed,the tumor volume and the spleen as well as thymus weight were measured. Results: The tumor inhibiting rates of the HPP, CS and combining group were 66. 9% ,68. 8% and 71. 8% respectively. The splenic and thymus indexes of the lung cancer mice in the HPP and combing group were higher than the CS group,and the difference was statistically significant ( P < 0. 05) . The serum IL - 2 levels of in the HPP and combing group were also higher than the CS group,and the difference was statistically significant ( P < 0. 05) . Conclusion: The Health - enhancing and Phlegm - removing Prescription has certain tumor suppression effect and its combination with cisplatin is better for it can effectively reduce theside effects of cisplatin.

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备注/Memo

备注/Memo:
收稿日期:2016-09-21编辑:文颖娟
基金项目:咸阳市科技局项目(2012K16-02);陕西中医药大学附属医院科研项目(2014-30)
更新日期/Last Update: 2017-07-15