[1]史磊磊曹珊珊张雨涵赵博深史永恒韩朝军 刘继平.真武汤方药解析及临床应用的研究进展[J].陕西中医药大学学报,2024,(06):141-145.[doi:10.13424/j.cnki.jsctcm.2024.06.024]
 SHI LeileiCAO ShanshanZHANG YuhanZHAO Boshen SHI YonghengHAN ChaojunLIU Jiping.Research Progress on the Drug Analysis and Clinical Application of Zhenwu Decoction[J].Journal of Shaanxi University of Traditional Chinese Medicine,2024,(06):141-145.[doi:10.13424/j.cnki.jsctcm.2024.06.024]
点击复制

真武汤方药解析及临床应用的研究进展()
分享到:

《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2024年06期
页码:
141-145
栏目:
出版日期:
2024-11-20

文章信息/Info

Title:
Research Progress on the Drug Analysis and Clinical Application of Zhenwu Decoction
文章编号:
2096-1340(2024)06-0141-05
作者:
史磊磊曹珊珊张雨涵赵博深史永恒韩朝军 刘继平
陕西中医药大学,陕西 咸阳 712046
Author(s):
SHI LeileiCAO ShanshanZHANG YuhanZHAO Boshen SHI YonghengHAN ChaojunLIU Jiping
Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China
关键词:
关键词:真武汤方药解析临床应用伤寒论
Keywords:
Key words: Zhenwu decoctionAnalysis of prescription drugsClinical applicationTreatise on Cold Damage
分类号:
R285.1
DOI:
10.13424/j.cnki.jsctcm.2024.06.024
文献标志码:
A
摘要:
摘要:经典名方真武汤源于张仲景所著《伤寒论》,并收录于国家中医药管理局所发布的《古代经典名方目录(第一批)》。真武汤属祛湿剂类,善利水温阳,治各类水湿邪盛之证,并对太阳、少阴之阳虚水滞病机有独到的治疗作用,现代常用该方治疗阳虚水泛之心力衰竭、慢性肾功能衰竭及帕金森等水湿内停病症。现对真武汤的方药进行解析,并通过对真武汤的现代临床相关研究进行总结,为其他相关疾病的临床治疗提供理论依据。
Abstract:
Abstract: The classic formula Zhenwudecoction originates from ZHANG Zhongjing’s Treatise on Cold Damage and is included in the Catalogue of Ancient Classic Formulas (First Batch) published by the State Administration of Traditional Chinese Medicine.Zhenwu decoction belongs to the category of dampness dispelling agents,which is good at promoting water and warming Yang,treating various types of water dampness and pathogenic diseases,and has unique therapeutic effects on the mechanism of Yang deficiency and water stagnation caused by the Yang deficiency and water stagnation of Taiyang and Shaoyin.It is commonly used in modern times to treat heart failure caused by Yang deficiency and water flooding,chronic renal failure,Parkinson’s disease and other water dampness disorders.We will now analyze the formula of Zhenwu decoction and summarize its modern clinical research to provide theoretical basis for the clinical treatment of other related diseases.

参考文献/References:

[1]毛妍,梁慧慧,朱俊平,等.真武汤的方证解析与现代研究概况[J].中国实验方剂学杂志,2020,26(1):217-225.
[2]吕萍,莫劲松,王菊萍,等.加味真武汤对充血性心力衰竭少阴病阳虚水停证兔血流动力学的影响[J].中国中医药信息杂志,2004,11(6):489-491.
[3]杜丽,熊曼琪,梅国强,等.加味真武汤对充血性心力衰竭少阴病阳虚水停证兔心肌细胞凋亡的影响[J].中国医药学报,2000,15(2):26-29,38.
[4]朱奔奔,郭维,黄亮,等.真武汤对慢性充血性心力衰竭模型大鼠ET、CGRP水平的影响[J].江苏中医药,2005,37(8):49-51.
[5]何岚,蔡宇,陈朝晖,等.真武汤对大鼠阿霉素肾病的治疗作用及其机理研究[J].中国实验方剂学杂志,2006,12(2):51-53.
[6]孙香娟,常克,张娟,等.真武汤对肾病综合征大鼠肾脏水通道蛋白2的影响[J].天津中医药,2010,27(5):416-417.
[7]LAVI I,FRIESEM D,GERESH S,et al.An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells[J].Cancer Letters,2006,244(1):61-70.
[8]邓刚民,许津.茯苓素:一种潜在的醛固酮拮抗剂[J].中国抗生素杂志,1992,17(1):34-37.
[9]申利,翁丹卉.茯苓酸抑制TRIM29表达通过Wnt信号通路调控宫颈癌细胞存活和凋亡[J].广州中医药大学学报,2020,37(1):140-146.
[10]邢磊,屈苗苗,张晓云.桂枝茯苓丸对大鼠卵巢癌移植瘤的抑瘤作用及其机制[J].西部医学,2020,32(4):515-519.
[11]牛爽,郝利民,赵树欣,等.茯苓多糖的研究进展[J].食品科学,2012,33(13):348-353.
[12]许浩,卢静,曲彩红.茯苓多糖的药理作用研究概况[J].临床合理用药杂志,2015,8(16):175-176.
[13]贾岚,王蕾蕾,孟靓,等.白芍总苷对大鼠化学性肝损伤与肝阴虚证结合模型的影响和机制研究[J].中草药,2020,51(7):1885-1892.
[14]吴丽,王丽丽,费文婷,等.芍药苷和芍药内酯苷对小鼠疼痛模型的镇痛作用及对β-EP、PGE2的影响[J].中华中医药杂志,2018,33(3):915-918.
[15]YU HY,MU DG,CHEN J,et al.Suppressive effects of intrathecal paeoniflorin on bee venom-induced pain-related behaviors and spinal neuronal activation[J].Pharmacology,2011,88(3/4):159-166.
[16]LIU BH,LIN J,BAI LX,et al.Paeoniflorin inhibits mesangial cell proliferation and inflammatory response in rats with mesangial proliferative glomerulonephritis through PI3K/AKT/GSK-3β pathway[J].Frontiers in Pharmacology,2019,10:978.
[17]MEHRZADI S,KHALILI H,FATEMI I,et al.Zingerone mitigates carrageenan-induced inflammation through antioxidant and anti-inflammatory activities[J].Inflammation,2021,44(1):186-193.
[18]CHEN X,SHEN J,ZHAO JM,et al.Cedrol attenuates collagen-induced arthritis in mice and modulates the inflammatory response in LPS-mediated fibroblast-like synoviocytes[J].Food & Function,2020,11(5):4752-4764.
[19]TIAN L,QIAN WB,QIAN QH,et al.Gingerol inhibits cisplatin-induced acute and delayed Emesis in rats and minks by regulating the central and peripheral 5-HT,SP,and DA systems[J].Journal of Natural Medicines,2020,74(2):353-370.
[20]CALABRESE V,LODI R,TONON C,et al.Oxidative stress,mitochondrial dysfunction and cellular stress response in Friedreich’s Ataxia[J].Journal of the Neurological Sciences,2005,233(1/2):145-162.
[21]WU MP,ZHANG YS,ZHOU QM,et al.Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway[J].Pharmacological Research,2016,104:115-123.
[22]YANG SW,CHU SF,AI QD,et al.Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF-κB and Nrf2/HO-1 signaling pathways[J].International Immunopharmacology,2020,85:106629.
[23]张涛,王桂杰,白书阁,等.附子对老年大鼠抗氧化系统影响的实验研究[J].中国老年学杂志,2001,21(2):135-136.
[24]陈琴华,余飞,王红梅,等.白术内酯Ⅰ、Ⅱ、Ⅲ对炎性巨噬细胞细胞因子表达的影响[J].中国药师,2017,20(12):2112-2116.
[25]苏祖清,曾科学,孙朝跃,等.白术挥发油对代谢综合征大鼠糖脂代谢的影响[J].亚太传统医药,2018,14(10):4-7.
[26]周剑,苏德春,宋国权.白术多糖对H22肝癌小鼠抗肿瘤作用实验研究[J].亚太传统医药,2015,11(17):9-10.
[27]傅奕,李鑫,朱莹,等.慢性肾功能衰竭用药规律及潜在机制分析[J].中国实验方剂学杂志,2022,28(6):151-158.
[28]林恩羽.真武汤加减延缓肾功能衰竭的效果观察[J].医学食疗与健康,2020,18(19):43-44.
[29]陈鸿艳.真武汤治疗慢性肾功能衰竭的疗效以及对肾动脉血流动力学的影响[J].四川中医,2018,36(3):121-123.
[30]徐海丽.真武汤加味佐治阳虚水肿型慢性肾衰40例疗效观察[J].国医论坛,2017,32(1):7-8.
[31]孙成力,真武汤加味温补心肾治疗早中期慢性肾衰脾肾阳虚证的临床研究[Z].上海:上海市宝山区中西医结合医院,2018-03-29.
[32]黄志萍,肖丹丹,石怀英,等.医养结合中医药特色健康管理模式在老年糖尿病中应用效果[J].中国老年学杂志,2022,42(18):4598-4600.
[33]周荣华.真武汤治疗糖尿病肾病的临床效果研究[J].名医,2021(13):56-57.
[34]俞叶娜.真武汤治疗糖尿病肾病的临床效果[J].糖尿病新世界,2021,24(5):189-191.
[35]刘双,胡才理.真武汤治疗糖尿病肾病的临床效果研究[J].中国处方药,2020,18(3):133-135.
[36]杨薪博,刘超,梅安存.加味真武汤在糖尿病肾病临床治疗中的疗效研究[J].现代中医药,2018,38(6):20-21,30.
[37]李世军.老年心力衰竭流行病学和病理生理学及预后的研究进展[J].中华老年心脑血管病杂志,2021,23(3):318-320.
[38]任艳芸,袁敏惠,陈景平.真武汤治疗慢性心衰的概况[J].陕西中医学院学报,2005,28(2):63-64.
[39]李嘉宁,陈鹏,王春莹.真武汤加味治疗慢性心力衰竭(阳虚水泛证)临床观察[J].中国中医急症,2022,31(6):1052-1054.
[40]高阳.真武汤治疗心肾阳虚型慢性心力衰竭临床观察[J].中国中医药现代远程教育,2022,20(4):90-92.
[41]华金根,祝正誉,刘雪佳.真武汤治疗心肾阳虚型慢性心力衰竭的临床疗效[J].深圳中西医结合杂志,2022,32(2):41-44.
[42]史亚楠.帕金森病和血管性帕金森综合征中医证候及临床特点比较研究[D].北京:北京中医药大学,2015.
[43]李彬,冯毅,周德安.真武汤加减治疗帕金森病32例临床观察[J].中国中医药信息杂志,2006,13(11):73-74.
[44]李进,王丽,汪仁斌,等.史载祥运用真武汤治疗不自主运动验案[J].中华中医药杂志,2017,32(4):1606-1609.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(82304504);陕西省自然科学基础研究计划(2022JQ-918)
更新日期/Last Update: 2024-11-21