[1]聂发毅 吴宇蔚 薛思梦 乔海法.耳针干预对精神分裂症模型小鼠阴性症状的影响[J].陕西中医药大学学报,2024,(05):103-106.[doi:10.13424/j.cnki.jsctcm.2024.05.017]
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耳针干预对精神分裂症模型小鼠阴性症状的影响()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2024年05期
页码:
103-106
栏目:
出版日期:
2024-09-09

文章信息/Info

文章编号:
2096-1340(2024)05-0103-04
作者:
聂发毅 吴宇蔚 薛思梦 乔海法
陕西中医药大学，陕西 咸阳 712046
关键词:
关键词：耳针; 精神分裂症; 阴性症状; 耳迷走神经; EGR3
分类号:
R245.32+3
DOI:
10.13424/j.cnki.jsctcm.2024.05.017
文献标志码:
A
摘要:
摘 要：目的 观察耳针干预对精神分裂症模型小鼠阴性症状的影响。方法 C57BL/6小鼠随机分为对照组、模型组、耳针组，每组8只。对照组注射对照病毒，其余各组将表达EGR3的腺相关病毒注射至小鼠腹侧海马区建立精神分裂症小鼠模型；耳针组在模型上施用耳针治疗。采用矿场实验与高架十字实验检测各组小鼠自发活动与焦虑样行为，采用三箱社交实验检测各组小鼠社交行为。结果 模型组小鼠在旷场箱内活动总距离与对照组和耳针干预组没有明显差异，模型组小鼠在旷场中心区域停留的时间与对照组相比明显降低（P<0.05）；耳针治疗后，小鼠在中心区域的停留时间较模型组显著增加（P<0.05）；高架十字实验结果显示，与对照组相比，模型组小鼠在开臂停留时间减少（P<0.001），在闭臂停留时间增加（P<0.05）；耳针干预组小鼠在开臂停留时间较模型组增加（P<0.05），在闭臂停留时间较模型组减少（P<0.05）；三箱社交实验结果显示，模型组小鼠在有陌生小鼠和空白室内停留时间没有差异，在陌生小鼠和熟悉小鼠室内停留时间没有差异。耳针干预组小鼠在陌生小鼠的室内停留时间较空白笼长（P<0.05），与熟悉的小鼠相比，其在陌生小鼠室内停留时间长（P<0.05）。结论 耳针干预可改善精神分裂症模型小鼠焦虑水平和社交能力等阴性症状。本研究为耳针治疗精神分裂症提供了实验依据。

参考文献/References:

［1］COLLABORATORS GBDMD.Global,regional,and national burden of 12 mental disorders in 204 countries and territories,1990-2019:a systematic analysis for the Global Burden of Disease Study 2019［J］.Lancet Psychiatry,2022,9(2):137-150.
［2］HUANG Y,WANG Y,WANG H,et al.Prevalence of mental disorders in China:a cross-sectional epidemiological study［J］.The Lancet Psychiatry,2019,6(3):211-224.
［3］VAN DEN NOORT M,YEO S,LIM S,et al.Acupuncture as Add-On Treatment of the Positive,Negative,and Cognitive Symptoms of Patients with Schizophrenia:A Systematic Review［J］.Medicines(Basel,Switzerland),2018,5(2):29.
［4］刘敬萱,孙彦辉,张莘,等.耳针理论学说的研究现状与思考［J］.针刺研究,2021,46(10):893-900.
［5］王红,刘晓茹,姜劲峰,等.耳皮内刺治疗抑郁症的临床观察［J］.中国中医基础医学杂志,2020,26(4):526-528.
［6］ZHANG R,LU S,MENG L,et al.Genetic evidence for the association between the early growth response 3(EGR3)gene and schizophrenia［J］.PLoS One,2012,7(1):e30237.
［7］YAMADA K,GERBER DJ,IWAYAMA Y,et al.Genetic analysis of the calcineurin pathway identifies members of the EGR gene family,specifically EGR3,as potential susceptibility candidates in schizophrenia［J］.Proc Natl Acad Sci U S A,2007,104(8):2815-2820.
［8］KIM SH,SONG JY,JOO EJ,et al.EGR3 as a potential susceptibility gene for schizophrenia in Korea［J］.Am J Med Genet B Neuropsychiatr Genet,2010,153b(7):1355-1360.
［9］HUENTELMAN MJ,MUPPANA L,CORNEVEAUX JJ,et al.Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk［J］.PLoS One,2015,10(10):e0135076.
［10］GALLITANO-MENDEL A,WOZNIAK DF,PEHEK EA,et al.Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effects［J］.Neuropsychopharmacology,2008,33(6):1266-1275.
［11］SONG T,NIE B,MA E,et al.Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia［J］.Biochem Biophys Res Commun,2015,460(3):678-683.
［12］XIAO X,XU X,LI F,et al.Anti-inflammatory treatment with beta-asarone improves impairments in social interaction and cognition in MK-801 treated mice［J］.Brain Res Bull,2019,150:150-159.
［13］WANG X,LUO C,MAO XY,et al.Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats［J］.Brain Res,2019,1719:30-39.
［14］JEONG Y,BAE HJ,PARK K,et al.4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice［J］.Journal of Ethnopharmacology,2022,285:114864.
［15］STEPNICKI P,KONDEJ M,KACZOR AA.Current Concepts and Treatments of Schizophrenia［J］.Molecules,2018,23(8).
［16］钟琴,田真真,晏敏.中医药治疗精神分裂症的研究进展［J］.江西中医药,2022,53(6):67-69.
［17］林琴韵,杨朝阳.中医药治疗精神分裂症研究进展［J］.河南中医,2022,42(9):1429-1434.
［18］周林艳,刘文娟.中医情志护理和耳穴压豆对精神分裂症患者认知功能和社会功能的影响［J］.新中医,2020,52(14):144-146.
［19］宋欣欣,安琦,李玉焕.针灸治疗精神分裂症的研究进展［J］.双足与保健,2019,28(3):25-26.
［20］宁式颖,郑璐,李响,等.针灸治疗精神分裂症取穴规律研究［J］.中医药信息,2015,32(2):31-34.
［21］黄庆元,李建国.耳针治疗精神分裂症幻听34例［J］.甘肃中医学院学报,2005,22(1):36-38.
［22］王美娜,张永臣,王家振,等.项七针联合耳穴贴压治疗首发精神分裂症32例［J］.中国针灸,2022,42(3):355-356.
［23］杨杰,张晓明,马新英,等.耳穴压豆联合奥氮平治疗精神分裂症的临床研究［J］.陕西中医,2015,36(7):829-830.
［24］戴铁城.以耳压法为主治疗青春型精神分裂症［J］.甘肃中医,1994,7(4):25.
［25］HILZ MJ.Transcutaneous vagus nerve stimulation - A brief introduction and overview［J］.Auton Neurosci,2022,243:103038.
［26］WANG L,WANG Y,WANG Y,et al.Transcutaneous auricular vagus nerve stimulators:a review of past,present,and future devices［J］.Expert Review of Medical Devices,2022:1-19.
［27］BUTT MF,ALBUSODA A,FARMER AD,et al.The anatomical basis for transcutaneous auricular vagus nerve stimulation［J］.J Anat,2020,236(4):588-611.
［28］LIU CH,YANG MH,ZHANG GZ,et al.Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression［J］.Journal of neuroinflammation,2020,17(1):54.
［29］YU Y,HE X,WANG Y,et al.Transcutaneous auricular vagal nerve stimulation inhibits limbic-regional P2X7R expression and reverses depressive-like behaviors in Zucker diabetic fatty rats［J］.Neurosci Lett,2022,775:136562.
［30］PEREZ SM,CARRENO FR,FRAZER A,et al.Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia［J］.J Neurosci,2014,34(28):9261-9267.

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备注/Memo

备注/Memo:
基金项目：陕西省科技厅项目（2019JM-399)
更新日期/Last Update: 2024-09-09