[1]杨 洋,惠 阳,王战争,等.结直肠癌患者中医证型和细胞免疫功能的相关性分析[J].陕西中医药大学学报,2019,(03):102-107.[doi:10.13424/j.cnki.jsctcm.2019.03.027]
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结直肠癌患者中医证型和细胞免疫功能的相关性分析 ()
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《陕西中医药大学学报》[ISSN:2096-1340/CN:61-1501/R]

卷:
期数:
2019年03期
页码:
102-107
栏目:
临床研究
出版日期:
2019-05-30

文章信息/Info

文章编号:
2096-1340(2019)02-0102-06
作者:
杨 洋;  惠 阳;  王战争; 马艳侠
1.陕西中医药大学,陕西咸阳712046;2.陕西中医药大学附属医院,陕西咸阳712000
关键词:
ＣＲＣ; 中医证型; 回顾性分析; 免疫细胞功能
分类号:
R735
DOI:
10.13424/j.cnki.jsctcm.2019.03.027
文献标志码:
A
摘要:
目的探讨结直肠癌(CRC)患者中医虚实证型与细胞免疫功能之间的关系,明确中药联合化疗治疗对CRC患者免疫功能的影响?方法收集2017年1月~2017年12月陕西中医药大学附属医院肿瘤科95例CRC住院患者,将其辨证分型分为实证(热毒蕴结证)?虚实错杂证(气滞血瘀证)和虚证(气阴两虚证)?检测T细胞亚群(CD3+?CD3+CD4+?CD3+CD8+?CD4+/CD8+)?B细胞?NK细胞百分比细胞免疫功能指标,分析CRC患者中医证型与免疫功能指标之间的关系?经过半年中药联合化疗治疗后,观察CRC患者免疫功能指标的变化?结果95例CRC患者外周血CD3+T细胞百分比实证组>虚证组,差别具有统计学意义(P<0.05)?外周血CD3+CD4+T细胞百分比实证组>虚证组?虚实错杂组>虚证组,差别具有统计学意义(P<0.05)?患者外周血CD4+/CD8+细胞比值虚实错杂组>实证组,虚实错杂组>虚证组,差别具有统计学意义(P<0.05)?患者外周血NK细胞百分比虚证组>实证组,差别具有统计学意义(P<0.05)?治疗后,气阴两虚证(虚证)患者CD3+T细胞(t=-4.740,P=0.000)?CD3+CD4+T细胞(t=-3.084,P=0.006)明显上升,有统计学意义?结论虚证CRC患者的免疫细胞功能被显著抑制,中药联合化疗治疗可显著提高CRC患者的细胞免疫功能?

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更新日期/Last Update: 2019-05-29