[1] Gao Shanqing, Wen Hongzhu, BianHui, et al. A Clinical Study on 33 Cases with Refractory Functional Dyspepsia Postprandial Discomfort Syndrome Treated by Li Donghuan Xiao Pi Pill [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2020, (03): 62-68. [doi: 10.13424/j.cnki.jsctcm.2020.03.017]
A Clinical Study on 33 Cases with Refractory Functional Dyspepsia Postprandial Discomfort Syndrome Treated by Li Donghuan Xiao Pi Pill
- Article number:
- 2096-1340(2020)03-0062-07
- Keywords:
- Xiao Pi Pill; Refractory Functional Dyspepsia ; Postprandial Discomfort Syndrome; clinical study
- ZTFLH:
- R255.3
- Code:
- A
- Abstract:
- Objective To evaluate the clinical effect on treating Refractory Functional Dyspepsia Postprandial Discomfort Syndrome by Li Donghuan Xiao Pi Pill. Methodology The patients with Refractory Functional Dyspepsia Postprandial Discomfort Syndrome are divided into two groups which are treated by Xiao Pi concentrated granules and the placebo granules respectively for a period of 4 weeks by means of the random, double - blind, and placebo control lab experiment. The observation index includes the overall clinical syndrome score and single clinical syndrome score. The main outcome measurement is the overall clinical syndrome effective rate, and the secondary is the single clinical syndrome disappearance rate and the improvement rate of symptom score. Result Among 65 cases, 33 are divided into Xiao Pi Pill and placebo group with 3 detached for each group, thereby 30 cases are actually accomplished in each group. The analysis of overall effective rate for each group is 66. 7% vs 36. 7% ( P = 0. 02) and 60. 61% vs 33. 33% ( P = 0. 014) respectively by means of FAS and PPS. Xiao Pi Pill Group is significantly higher than its counterpart in terms of the disappearance and improvement rate of the postprandial fullness, fullness in the morning and the discomfort in upper - middle abdomen( P <0. 05) . No adverse event occurs to the Xiao Pi Pill group, by contrast, 3 with the placebo group thws, there is no statistical significance between two groups( P >0. 05) . Conclusion Xiao Pi Pill can effectively improve the clinical symptoms caused by the Refractory Functional Dyspepsia Postprandial Discomfort Syndrome with security.
References:
[1] Drossman, D. A. Functional Gastrointestinal Disorders:History, Pathophysiology, Clinical Features, and Rome IV [ J] . Gastroenterology, 2016, 150 ( 6 ) , 1262 -1279. e2.
[2]吴柏瑶,张法灿,梁列新.功能性消化不良的流行病学[J].胃肠病学和肝病学杂志,2013,22(1):85-90.
[3] Hamilton J , Guthrie E , Creed F , et al. A Randomized Controlled Trial of Psychotherapy in Patients With Chronic Functional Dyspepsia [ J] . Gastroenterology, 2000, 119( 3) :661 -669.
[4]孙小娟,贾林,王胜炳,等.难治性功能性消化不良及其亚型患者的抑郁焦虑状况及其对生活质量影响的调查[J].现代消化及介入诊疗,2015,20(4):332-335.
[5]张年顺,吴少祯,张海凌,等.李东垣医学全书[M].北京:中国中医药出版社,2006,88
[6] Stanghellini V, Talley N J, Chan F, et al. Rome IV -Gastroduodenal Disorders[ J] . Gastroenterology, 2016,150( 6) :1380 -92
[7]张声生,赵鲁卿.功能性消化不良中医诊疗专家共识意见(2017)[J].中华中医药杂志,2017,32(6):2595-2598.
[8] Tack J, Bisschops R, Sarnelli G. Pathophysiology and treatment of functional dyspepsia[ J] . Gastroenterology,2004, 127( 4) :1239 -1255.
[9]孙小娟,贾林,王胜炳,等.难治性功能性消化不良患者的行为学特征分析[J].现代消化及介入诊疗,2015,20(5):463-466.
[10]冯辉,藏莉,张德重.半夏泻心汤对功能性消化不良患者血浆P物质和胃窦黏膜CGRP的影响[J].南京中医药大学学报,2015,31(4):310-313
[11] Hongli Wu, Zhiwei Jing, Xudong Tang, et al. To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen - deficiency and qi- stagnation syndrome: a randomized group sequential comparative trial[ J] . BMC Gastroenterology, 2011, 11 ( 1) , DOI:10. 1186/1471 -230X -11 -81
[12]窦丹波,蔡淦,王松坡,等.枳实消痞丸不同剂型治疗功能性消化不良的临床研究[J].中国中西医结合消化杂志,2006,14(2):86-89
[13] Lin Lv, Feng - Yun Wang, Xiang - Xue Ma, et al. Efficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi - center randomized doubleblind placebo - controlled clinical study[ J] . World J Gastroenterol, 2017, 23( 30) :5589 -5601
[14]何泮,郑粤文,游敏玲.和中方递减法配合心理疏导治疗老年难治性功能性消化不良的临床观察[J].吉林中医药,2006,26(4):22-23.
[15]刘艳敏,陈敏,付道时.温胆汤加味联合黛力新治疗难治性功能性消化不良伴睡眠障碍的效果观察[J].中国实用医药,2017,12(16):22-24.
[16] Zheng H, Xu J, Sun X, et al. Electroacupuncture for patients with refractory functional dyspepsia: A randomized controlled trial. [ J] . Neurogastroenterology Motil,2018,30( 7) : e13316. doi: 10. 1111/ nmo. 13316.
Memo
基金项目:上海市中医专科(专病)联盟建设项目(ZY(2018-2020)-FWTX-4018)