[1] YANG KangdiWANG YichuanZHANG XuSHAO MingcongLI ZiyanWANG Lina,.Application and Mechanism of Warm Traditional Chinese Medicine in the Treatment of Primary Liver Cancer [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2024, (04): 18-22. [doi: 10.13424/j.cnki.jsctcm.2024.04.004]
Application and Mechanism of Warm Traditional Chinese Medicine in the Treatment of Primary Liver Cancer
- Article number:
- 2096-1340(2024)04-0018-05
- Keywords:
- Key words： Warm type; Traditional Chinese medicine; Primary liver cancer; Clinical treatment; Mechanism
- ZTFLH:
- R735.7
- Code:
- A
- Abstract:
- Abstract： Liver cancer，as a common and difficult to treat tumor in clinical practice，has always had a high mortality rate.Traditional medicine has a unique theoretical system and methods for the treatment of liver cancer.Based on the classics，this study explores the function of Yin and Yang by exploring the concept of “Yang transforming Qi and Yin forming shape”，as well as the discussion in Ling Shu，which concludes that tumors possess the attribute of “Yin”;Combined with the physiological attribute of the liver’s “body Yin and using Yang”，it is believed that the application of warm and hot traditional Chinese medicine in the treatment of primary liver cancer is worth paying attention to.The article reviews the clinical application of warm and hot traditional Chinese medicine in the treatment of liver cancer from the perspective of warming Yang and dispersing cold.Evidence is sought from basic experiments of different warm and hot traditional Chinese medicine in liver cancer，and it is concluded that in the treatment of liver cancer，attention should not only be paid to the methods of clearing heat and detoxifying，but also to the application of warming Yang and dispersing cold.Provided different approaches for the clinical treatment of liver cancer.
References:
［1］BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA:a Cancer Journal for Clinicians,2018,68(6):394-424.
［2］杨智海.原发性肝癌治疗中祛邪与扶正的关系［J］.陕西中医学院学报,1990,13(2):23-25.
［3］阳国彬,刘松林,刘玉芳.中医药辨治原发性肝癌研究概况［J］.中医药临床杂志,2020,32(1):175-181.
［4］张颖,李崇慧.国医大师徐经世运用中医药治疗肝癌经验拾萃［J］.陕西中医药大学学报,2018,41(5):22-24.
［5］王洪绪.外科全生集:四卷［M］.新1版.潘器之，编.上海:上海卫生出版社,1956:7.
［6］戚益铭,吴霜霜,沈敏鹤,等.中医药治疗原发性肝癌研究述评［J］.中医学报,2015,30(1):14-16.
［7］张军茹,张冠杰.“阳化气、阴成形” 理论及其在心衰治疗中应用价值探讨［J］.中医药临床杂志,2014,26(4):336-337.
［8］李如辉,黄兆鋆.“阳化气,阴成形” 诠释及其理论意义［J］.中医药学刊,2002,20(7):87.
［9］蒋锐沅,荣震,满婷婷,等.基于“阳化气,阴成形” 理论探讨原发性肝癌的病因与治法［J］.四川中医,2020,38(4):33-36.
［10］王文成,王彬彬.吴良村应用“肝体阴而用阳” 理论治疗原发性肝癌经验［J］.辽宁中医杂志,2015,42(7):1195-1197.
［11］张璐.张氏医通［M］.上海:锦章堂图书局,1935.
［12］王梅.肝为刚脏辨析［J］.山东中医药大学学报,2016,40(1):23-24.
［13］叶天士.临证指南医案［M］.苏礼，等整理.北京:人民卫生出版社,2006.
［14］周文献.“肝体阴而用阳” 刍议［J］.山东中医杂志,2000,19(11):645-646.
［15］王红玲,康斐,黄兴.基于“阳化气,阴成形” 理论探讨温阳法在恶性肿瘤中的应用［J］.中国中医基础医学杂志,2019,25(7):999-1002.
［16］高学敏,李兴广.《药性赋》白话解［M］.北京:北京中医药大学,1960.
［17］赵远红.恶性肿瘤“温药和之” 解析［J］.新中医,2008,40(7):100.
［18］张佳艺,闫梓乔,杜璐瑶,等.乌头抗肿瘤的应用及研究［J］.中医药导报,2019,25(10):45-49.
［19］张锡纯.医学衷中参西录:合订本［M］.河北新医大学《医学衷中参西录》修订小组，修订.石家庄:河北人民出版社,1977.
［20］王强,高峰,曹妮达.杨金坤治疗肝癌经验［J］.中医肿瘤学杂志,2020,2(1):76-80.
［21］林霜,魏克民.魏克民对恶性腹水的辨证施治［J］.陕西中医学院学报,2014,37(2):17-18.
［22］孙佳,叶丽红.名老中医治疗肝癌经验研究评述［J］.中医学报,2012,27(6):658-660.
［23］吴普.经典医学名著:神农本草经［M］.上海:第二军医大学出版社,2005:86-87,94-95,140,147,157,231.
［24］孙秉严.治癌秘方［M］.北京:华龄出版社,1992:1-280.
［25］王三虎.薏苡附子败酱散［J］.河南中医,2017,37(11):1955.
［26］陶志广.桂枝汤类方在肝癌治疗中的价值初探［J］.四川中医,2007,25(10):125-126.
［27］阳国彬,刘玉芳.《伤寒论》桂枝汤类方辨治肝癌并发症体会［J］.中医药通报,2017,16(6):26-28.
［28］林杰,邓厚波,沈东,等.刘铁军教授运用扶阳益气法治疗肝癌发热临床经验［J］.中西医结合肝病杂志,2018,28(3):185-187.
［29］赖春娥,刘思亮.肉桂粉调醋外敷双足三里、内关穴促进原发性肝癌行腹腔镜下肝切除术后胃肠功能恢复的疗效分析［J］.中医临床研究,2019,11(30):83-86.
［30］干宝善.治疗肝癌疼痛的中草药汤剂及制备方法:CN1814258A［P］.2006-08-09.
［31］吴塘.温病条辨第三卷［M］.北京：中国中医药出版社，2012.
［32］赵尚华,靳建云,牛玉洁.升降散临证应用举隅［J］.山西中医,2005,21(6):3-4.
［33］林铭堉.《神农本草经》对研发抗肿瘤中药的贡献［D］.广州:广州中医药大学,2011.
［34］何秀兰,周而复,袁尚华,等.王沛教授治肝癌临床经验总结［J］.中国中医基础医学杂志,2004,10(3):70-71.
［35］陶志广.周岱翰教授治疗肝癌临证经验［J］.天津中医药,2004,21(3):182-184.
［36］王志学.活血化瘀七法治疗原发性肝癌［J］.中医药研究,1999(5):30-31.
［37］裴俊文.蒋士卿教授运用温阳法治疗恶性肿瘤经验［J］.河南中医,2009,29(2):129-130.
［38］杨璇,刘永刚,常占杰.常占杰教授运用补中益气汤治疗肝癌发热经验［J］.现代中医药,2016,36(4):1-3.
［39］彭磷基,陆大祥.肝癌治疗学的研究进展［J］.中国老年学杂志,2009,29(5):628-631.
［40］吴尚先.理瀹骈文［M］.孙洪生，校注.北京:中国医药科技出版社,2011:1.
［41］向彩琼,徐大志,邹丹,等.基于《理瀹胼文》外治理论谈热疗对肝癌的治疗［J］.中医药临床杂志,2020,32(10):1799-1802.
［42］王琮,孙一予,李小江.中药联合热疗在肝癌治疗中的应用［J］.世界中西医结合杂志,2010,5(9):803,827.
［43］赖春丽,黄婉锋,祝晨蔯,等.抗肿瘤中药新药开发探讨［J］.中药材,2003,26(9):677-80.
［44］左清平,张顺芝,刘世坤.姜黄素抑制NF-κB信号对人肝癌HepG2细胞株增殖的影响［J］.中南药学,2015,13(4):348-351.
［45］朱开梅,顾生玖,李美波,等.八角莽草酸诱导人肝癌细胞HepG-2凋亡及其机制研究［J］.中国实验方剂学杂志,2014,20(8):154-158.
［46］丁志山,高承贤,陈铌铍,等.姜黄素具有抑制血管生成与诱导肿瘤细胞凋亡双重作用［J］.中国药理学通报,2003,19(2):171-173.
［47］陈伟海,徐晓玉,胡益勇,等.阿魏酸钠对小鼠H22肝癌生长的抑制作用及其机制研究［J］.北京中医药大学学报,2006,29(10):690-693,701,723.
［48］唐渊,李晓辉.莪术提取物对肝癌细胞系HepG2的抗癌作用及机制研究［J］.中国药理学通报,2007,23(6):790-794.
［49］钱珍.附子多糖联用乌头碱对肝细胞肝癌的作用及机理初步研究［D］.南京:南京中医药大学,2015.
［50］李曦,张丽宏,王晓晓,等.当归化学成分及药理作用研究进展［J］.中药材,2013,36(6):1023-1028.
［51］商澎,杨铁虹,贾敏,等.当归多糖AP-0对小鼠移植性肿瘤的抑制作用［J］.第三军医大学学报,2001,23(11):1299-1302.
［52］冯晗,周宏灏,欧阳冬生.杜仲的化学成分及药理作用研究进展［J］.中国临床药理学与治疗学,2015,20(6):713-720.
［53］袁带秀,舒丽霞,黄蓉.杜仲黄酮对H22小鼠的抑瘤作用及其机制［J］.中国老年学杂志,2016,36(2):291-293.
［54］辛晓明,王大伟,赵娟,等.杜仲总多糖抗肿瘤作用的实验研究［J］.医药导报,2009,28(6):719-721.
［55］王谦,张玲,毛海婷,等.中药淫羊藿苷抑制肝癌HepG2.2.15细胞增殖和免疫逃逸作用研究［J］.中国免疫学杂志,2007,23(10):908-911.
［56］YU J,ZHOU XM,HE XS,et al.Curcumin induces apoptosis involving bax/bcl-2 in human hepatoma SMMC-7721 cells［J］.Asian Pacific Journal of Cancer Prevention:APJCP,2011,12(8):1925-1929.
［57］赵爽,郭星娴,周鹏,等.吴茱萸碱通过Hippo-YAP通路诱导人肝癌BEL-7402细胞凋亡的实验研究［J］.中草药,2019,50(20):4962-4968.
［58］朱秀琴,张学军.阿魏酸钠对人EBL-7404肝癌细胞的抑制作用［J］.肝脏,2001,6(1):19-20.
［59］SHANG P,YANG TH,JIA M,et al.Isolation and purification,analysis and determination of polysaccharides of Angelica sinensis (Oliv.) Diels［J］.Di-siJunyiDaxueXuebao (J Fourth Mil Med Univ)，2001,22(2):1-7.
［60］宋娜,吴施国,谢星星,等.中药干预肝癌及其疼痛的分子机制研究进展［J］.现代中医药,2021,41(4):1-6.
［61］孙建超,娄方方,史云,等.吴茱萸碱对肝癌HepG2细胞侵袭和迁徙的影响［J］.世界华人消化杂志,2015,23(10):1546-1552.
Memo
基金项目：国家自然科学基金项目（8177424，81303112）；上海市自然基金项目（12ZR1437400）