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[1] Hui Jianrong, Lv Yao, Li Yongfeng, et al. Effect and Mechanism of Pivot Function Promoting Acupuncture on Notch1 in Rats with Cerebral Ischemia [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2020, (01): 62-68. [doi: 10.13424/j.cnki.jsctcm.2020.01.017]

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Effect and Mechanism of Pivot Function Promoting Acupuncture on Notch1 in Rats with Cerebral Ischemia

Journal of Shaanxi University of Traditional Chinese Medicine[ISSN: 2096-1340/ CN: 61-1501/R] Volumes & Issues: 2020 01 pagination: 62-68 Column: Publication date: 2020-01-30

Article number:: 2096-1340(2020)01-0062-07

Author(s):: Hui Jianrong 1 ; Lv Yao 2 ; Li Yongfeng 1 ; Zhang Rui 3; 1. The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang China, 712000; 2. Peoples Hospital of Tongchuan, Tongchuan China, 727031; 3. Ankang TCM Hospital, Ankang China, 725000

Keywords:: Pivot Function Promoting Acupuncture; ischemic cerebral apoplexy; Notch signaling pathway; Notch1 protein

ZTFLH:: R289.51

DOI:: 10.13424/j.cnki.jsctcm.2020.01.017

Code:: A

Abstract:: Objective To investigate the effect of Pivot Function Promoting Acupuncture on neurological function repair and Notch 1 protein expression in rats with cerebral ischemia. Methods 10 out of the 60 male SD rats were randomly selected as the sham operation group. The remaining 50 rats were randomly divided into model control group, Lishu Acupuncture( Pivot Function Promoting Acupuncture) group, ordinary acupuncture group and Western medicine lavage group after MCAO modeling by suture method. Neurological function scores were obtained at the first day, third days, seventh day, and fourteenth day after modeling. The rats were sacrificed after 14 days to determine the percentage of cerebral infarction volume and the expression of Notch1 protein partially. Results On the 7th and 14th day after operation, compared with other groups, the nerve defect by Lishu Acupuncture was significantly improved ( P < 0. 01) ; Lishu Acupuncturecould significantly reduce the volume of cerebral infarction ( P < 0. 01) ; it could promote the expression of Notch – 1 protein after cerebral ischemia, and its effect was better than that of common acupuncture and Western medicine of lavage ( P < 0. 05 or P < 0. 01) . Conclusion Lishu Acupuncture can effectively improve the neurological function score and cerebral infarction volume in rats with cerebral ischemia, and promote the expression of Notch1 protein. The mechanism may be related to the Notch signaling pathway.

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基金项目：国家重点研发计划项目（２０１８ＹＦＣ１７０４６０６）；陕西省科技厅科技计划项目（２０１６ＪＱ８０２０）；陕西省教育厅科技计划项目（１４ＪＫ１２１１）；咸阳市科技局项目（２０１７ｋ－０２－１０１）；陕西省中医药管理局科研项目（ＬＣＰＴ１０３）作者简介：惠建荣（１９７８－），女，副教授，研究方向：中医、针灸防治疑难疾病的机理与临床研究。Ｅ－ｍａｉｌ：１５７６００９５８＠ｑｑ．ｃｏｍ

Last Update: 2020-01-15