[1] Zhi Liqin, Huang Jiaxin, Pei Jiwen,.Effect of Qijia Wuling Decoction Combined with Western Medicine on Cardiac Ultrasound Related Indexes in Heart Failure Mice [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2018, (05): 119-122. [doi: DOI:10．13424/j．cnki．jsctcm．2018．05．035]
Effect of Qijia Wuling Decoction Combined with Western Medicine on Cardiac Ultrasound Related Indexes in Heart Failure Mice
- Article number:
- 2096－1340(2018)04－0119－05
- Keywords:
- LVEF; LVESD; LVEDD; Qijia Wuling Decoction; heart failure mice
- ZTFLH:
- R541. 6
- Code:
- A
- Abstract:
- To observe the effect of Qijia Wuling Decoction combined with western medicine on LVEF， LVESD，LVEDD and FS of heart failure mice under cardiac uhrasonography and provide a strong theoretical foundation for clinic study． Method: By using coronary artery ligation，30 male Kunming mice were made into heart failure model were randomly divided into 3 groups: the model group ( 10) ，Qijia Wuling Decoction + western medicine group ( 10) ，western medicine group ( 10) ． After 48 hours，all heart failure mice were examined by echocardiography． When the ejection fraction was ＜45%， the index of heart failure was reached， indicating that the model was successful． The model group was given normal saline，Qijia Wuling Decoction + western medicine group and western medicine group were treated by gavage． After 4 weeks of treatment， the ultrasound － related indicators were observed． The data were analyzed by t test or analysis of variance between groups． Result: after 4 weeks of treatment， 1． Compared with the model group，LVEF of the Qijia Wuling Decoction + Western medicine group and the Western medicine group were improved to different extents， and there was statistical difference ( P ＜0． 05) ，and the effect in the Qijia Wuling Decoction + Western medicine group was more obvious ( P ＜0． 01) ． 2． Compared with the model group，LVESD of the Qijia Wuling Decoction + Western medicine group and the Western medicine group had different degrees of reduction，which was statistically significant ( P ＜0． 05) ，and the reduction and curative effect in the Qijia Wuling Decoction + Western medicine group was more obvious ( P ＜0． 01) ． 3． Compared with the model group，the LVEDD of the Qijia Wuling Decoction + Western medicine group increased with statistical difference ( P ＜0． 05) ，while the Western medicine group showed an increase in LVEDD ， but P ＞ 0． 05，which was not statistically significant． The LVEDD of the Qijia Wuling Decoction + Western medicine group was significantly higher than that of the Western medicine group，but P ＞0． 05，which was not statistically significant． 4． Compared with the model group，FS of the Qijia Wuling Decoction + Western medicine group and the Western medicine group were increased to different degrees，and there was statistical difference ( P ＜0． 05) ，and increase in the Qijia Wuling Decoction + Western medicine group was more obvious ( P ＜0． 01) ． Conclusion: Qijia Wuling Decoction can improve LVEF，reduce LVESD，increase LVEDD and improve FS of heart failure mice，Qijia Wuling Decoction is better than Western medicine in improving heart function in heart failure mice，affirming the clinical efficacy of Qijia Wul ing Decoction in treating heart failure and providing powerful theoretical theory basis．
References:
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Memo
基金项目:陕西省科技厅资助项目( 2013K12 －06 －04)
通讯作者:裴纪文( 1962 －) ，男，副主任医师，中医内科相关研究。E － maiL:13309296312@ qq． com收稿日期:2018 －06 －01 编辑:文颖娟