[1] ZHANG Qing GUO Yuanming LI Meibing ZUO Siyao WANG Guodong LIU Linfeng HAN Guangying WANG Guijuan YOU Xujun LAI Jinmao,.A study on Correlation Between Bone Density，Sex Hormones， and Traditional Chinese Medicine Syndrome Types in Elderly Patients with Primary Osteoporosis [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2024, (04): 31-36. [doi: 10.13424/j.cnki.jsctcm.2024.04.006]
A study on Correlation Between Bone Density，Sex Hormones， and Traditional Chinese Medicine Syndrome Types in Elderly Patients with Primary Osteoporosis
- Article number:
- 2096-1340(2024)04-0031-06
- Keywords:
- Key words： Primary osteoporosis in the elderly; Bone density; Sex hormones; Traditional Chinese Medicine syndrome types; Relativity
- ZTFLH:
- R259
- Code:
- A
- Abstract:
- Abstract： Objective To analyze the correlation between bone density，sex hormones，and traditional Chinese medicine syndrome types in elderly patients with primary osteoporosis (OP) in the community，and to provide a basis for the treatment of OP in the elderly with traditional Chinese medicine in the community.Methods A total of 347 elderly patients with primary osteoporosis who visited the Community Health Service Center of Bao’an District Traditional Chinese Medicine Hospital in Shenzhen from January 2020 to May 2022 were reviewed，including liver and kidney Yin deficiency syndrome，spleen and kidney Yang deficiency syndrome，Qi stagnation and blood stasis syndrome，and kidney Yang deficiency failure syndrome.The age，gender，bone density，serum testosterone (T)，and serum estradiol (E2) values of the patients were recorded，and the correlation between bone density，sex hormones，and traditional Chinese medicine syndrome differentiation was analyzed.Results Among 347 elderly patients with primary OP，there were 80 cases of liver and kidney Yin deficiency syndrome，88 cases of spleen and kidney Yang deficiency syndrome，90 cases of Qi stagnation and blood stasis syndrome，and 89 cases of kidney Yang deficiency failure syndrome;Among them，patients aged 60-70 are mainly characterized by Qi stagnation and blood stasis，patients aged 71-80 are mainly characterized by kidney Yang deficiency and failure，and patients aged 81-90 are mainly characterized by liver and kidney Yin deficiency;In the comparison of bone density values，the Qi stagnation and blood stasis syndrome was higher than other groups (P<0.05);In the comparison of serum testosterone (T) values，the Qi stagnation and blood stasis syndrome was higher than the other groups (P<0.05)，and the Kidney Yang deficiency syndrome was lower than the other groups (P<0.01);In the comparison of serum estradiol (E2) values，the Qi stagnation and blood stasis syndrome and kidney Yang deficiency and failure syndrome were higher than other groups (P<0.05)，and the differences were statistically significant;The proportion of fracture history in Qi stagnation and blood stasis syndrome was higher than that in other groups (P<0.05)，the proportion of osteoporosis in kidney Yang deficiency syndrome was higher than that in other groups (P<0.05)，and the proportion of severe osteoporosis in spleen kidney Yang deficiency syndrome was higher than that in other groups (P<0.05).Conclusion In the early stage of elderly patients with primary OP，Qi stagnation and blood stasis syndrome are the main symptoms，while in the later stage，they gradually develop into spleen kidney Yang deficiency syndrome，liver kidney Yin deficiency syndrome，and kidney Yang deficiency failure syndrome;The bone density value and sex hormone (serum testosterone，serum estradiol) value can be used as indicators to evaluate the deficiency excess syndrome type in elderly patients with primary osteoporosis，which is negatively correlated with deficiency syndrome and correlated with traditional Chinese medicine syndrome type.
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Memo
基金项目：国家自然科学基金青年项目（82104853）；深圳市宝安区科技创新局课题（2021JD260）