[1] LIU YanniJia NiYANG YifanFAN Xianling?ZHANG JingwenWANG NanZHANG ZitengYAN Yongmei,.Treatment of Parkinson’s Disease with Depression Based on???? Five Viscera Theory in Traditional Chinese Medicine [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2024, (01): 21-26. [doi: 10.13424/j.cnki.jsctcm.2024.01.004]
Treatment of Parkinson’s Disease with Depression Based on???? Five Viscera Theory in Traditional Chinese Medicine
- Article number:
- 2096-1340(2024)01-0021-06
- Keywords:
- Key words： Parkinsons disease with depression; Pathogenesis; The theory of the five viscera; Treatment
- ZTFLH:
- R277.7
- Code:
- A
- Abstract:
- Abstract： Depression symptoms are common throughout the disease in Parkinson’s disease patients,and the mechanism of depression in Parkinson’s disease is not yet clear,so treatment is limited.The “Five Viscera Theory” in traditional Chinese medicine believes that the human body is centered around the five organs,and Parkinson’s disease with depression is a process of “causing depression due to illness” or “causing disease due to depression”.Its onset is closely related to the five organs of “liver,heart,spleen,lung,and kidney”.Therefore,this article mainly explores the pathogenesis and treatment principles of Parkinson’s disease with depression from the perspective of the five organs,in order to provide effective reference for clinical practice.
References:
［1］胡琪,陶雪,蒋敏,等.丁苯酞治疗帕金森病研究进展［J］.医药导报,2023,42(2):203-207.
［2］Braak H,Rü BU,Jansen Steur ENH,et al.Cognitive status correlates with neuropathologic stage in Parkinson disease［J］.Neurology,2005,64(8):1404-1410.
［3］刘明,杨丽静,张鑫杰.中西医治疗帕金森病抑郁研究述评［J］.中国中医基础医学杂志,2021,27(1):173-177.
［4］陈坚雄,邱仕君,肖莹.试论中医五脏相关学说的理论内涵［J］.广州中医药大学学报,2007,24(2):87-90.
［5］赵欣,胡玉英.帕金森病抑郁的中西医治疗研究进展［J］.中医临床研究,2022,14(33):85-88.
［6］王晨曦,袁金敏,胡域峰,等.从肝肾论治疗帕金森病合并抑郁症［J］.世界中医药,2022,17(7):1003-1006,1012.
［7］肖开慧,任翼,徐帅,等.“肝主疏泄”的现代生物学阐释［J］.世界中医药,2022,17(24):3519-3523.
［8］王凯.肝主疏泄调畅情志机制探讨—调肝方药对抑郁症模型大鼠抑郁状态影响机制研究［D］.济南：山东中医药大学,2017.
［9］严灿,徐志伟.肝主疏泄调畅情志功能的中枢神经生物学机制探讨［J］.中国中西医结合杂志,2005,25(5):459-462.
［10］李晓红,李晶晶,刘玥芸,等.从慢性应激探讨肝郁脾虚证的中枢神经生物学机制［J］.中西医结合学报,2012,10(1):1-6.
［11］谢传同,扈洪波,尹淑涛,等.抑郁症机制及抗抑郁药食同源成分研究进展［J］.中国食品学报,2023,23(4):451-462.
［12］Goldstein DS,Holmes C,Sullivan P,et al.Elevated cerebrospinal fluid ratios of cysteinyl-dopamine/3,4-dihydroxyphenylacetic acid in parkinsonian synucleinopathies［J］.Parkinsonism & Related Disorders,2016,31:79-86.
［13］Ibrahimagic OC,Jakubovic AC,Smajlovic D,et al.Psychological stress and changes of hypothalamicpituitaryadrenal axis in patients withde novo Parkinsons disease［J］.Medical Archives,2016,70(6):445-448.
［14］Giordano N,Iemolo A,Mancini M,et al.Motor learning and metaplasticity in striatal neurons:relevance for Parkinsons disease［J］.Brain,2018,141(2):505-520.
［15］冯璐,董鹤婷,王乃娴,等.养心汤加减联合心理疗法治疗抑郁症的临床效果［J］.中华中医药学刊,2022,40(12):197-200.
［16］吴媛媛,孙晶,梁宜,等.方剑乔从心论治抑郁症经验探析［J］.浙江中医杂志,2020,55(6):405.
［17］抑郁障碍中西医整合诊治专家共识组,中国民族医药学会神志病分会.抑郁障碍中西医整合专家共识［J］.中国医药导报,2021,18(6):4-12.
［18］孙冬梅.从心论治中风病的理论研究［D］.济南:山东中医药大学,2008.
［19］刘思娜,连妍洁,仇盛蕾,等.基于数据挖掘具有脑心同治功效的中成药配伍规律研究［J］.世界中医药,2022,17(13):1928-1933,1938.
［20］冯治平.浅析疏肝健脾法治疗帕金森伴抑郁［J］.内蒙古中医药,2012,31(20):110.
［21］刘畅,李常慧,王姝元,等.基于脑肠微生物轴探讨益脾通腑法对帕金森病小鼠的干预机制［J］.现代中西医结合杂志,2022,31(10):1320-1327.
［22］Li YN,Yang LX,Li JN,et al.Antidepression of Xingpijieyu formula targets gut microbiota derived from depressive disorder［J］.CNS Neuroscience & Therapeutics,2023,29(2):669-681.
［23］Zhang C,Zhang YP,Li YY,et al.Minocycline ameliorates depressive behaviors and neuroimmune dysfunction induced by chronic unpredictable mild stress in the rat［J］.Behavioural Brain Research,2019,356:348-357.
［24］朱冬雨,陆征宇,陆玲丹,等.基于中医理论的帕金森病从肺论治［J］.神经病学与神经康复学杂志,2017,13(3):109-113.
［25］Bienenstock J,Collins S.99th Dahlem conference on infection,inflammation and chronic inflammatory disorders: psychoneuroimmunology and the intestinal microbiota: clinical observations and basic mechanisms［J］.Clinical and Experimental Immunology,2010,160(1):85-91.
［26］Mulak A,Bonaz B.Braingutmicrobiota axis in Parkinson’s disease［J］.World Journal of Gastroenterology,2015,21(37):10609-10620.
［27］刘丹丹,刘银辉,唐立.肠道菌群与神经精神疾病［J］.中国微生态学杂志,2017,29(7):850-854.
［28］郇鹏飞,何建成.肠道菌群对帕金森病并发抑郁症影响机制探析［J］.中国微生态学杂志,2022,34(8):969-973.
［29］李聪聪,赵允南,孙灵芝.肠道菌群失调与帕金森病的相关性及中医药干预［J］.中医学报,2021,36(12):2580-2584.
［30］范少凯,李炳翰,韩博雅,等.帕金森病伴抑郁的发病机制及治疗进展［J］.海南医学,2021,32(6):770-773.
［31］贺邵华,黄丽,方永奇,等.基于肝肾藏象理论的抑郁大鼠血脑神经递质变化与抑郁症的关系探讨［J］.时珍国医国药,2018,29(11):2814-2816.
［32］何勇,惠小珊,崔显勋,等.张金生教授运用防己茯苓汤加减治疗帕金森病经验［J］.中医临床研究,2018,10(36):5-7.
［33］雒晓东,文晓东,连新福,等.帕病2号方对肝肾不足型早期帕金森病中医证候的影响［J］.中医杂志,2013,54(1):32-34.
［34］谢磊,张鹏,罗瑞,等.基于“肾为元阳之本”探讨温补肾阳方治疗抑郁症［J］.中华中医药杂志,2011,26(5):1130-1134.
［35］Vian J,Pereira C,Chavarria V,et al.The reninangiotensin system:a possible new target for depression［J］.BMC Medicine,2017,15(1):1-13.
［36］Gong SZ,Deng F.Reninangiotensin system: the underlying mechanisms and promising therapeutical target for depression and anxiety［J］.Frontiers in Immunology,2023,13:1053136.
［37］Altamura AC,Zanchetti A.Renin and depression［J］.British Journal of Psychiatry,1978,132(4):414.
［38］Steenkamp LR,Hough CM,Reus VI,et al.Severity of anxiety but not depression is associated with oxidative stress in Major Depressive Disorder［J］.Journal of affective disorders,2017,219:193-200.
［39］温馨,王路,侯廷慧,等.基于神经-内分泌-免疫网络探讨针刺治疗抑郁症机制［J］.陕西中医药大学学报,2022,45(3):143-146.
［40］Du X,Pang TY.Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?［J］.Frontiers in psychiatry,2015,6:32.
［41］Verugina NI,Levin OS,Lyashenko EA.Neuroendocrine and metabolic impairments in patients with Parkinson’s disease［J］.Zhurnal nevrologii i psikhiatrii imeni S.S.Korsakova,Korsakova,2020,120(10):67.
［42］Zhang J,Xue B,Jing B,et al.LPS activates neuroinflammatory pathways to induce depression in Parkinson’s diseaselike condition［J］.Front Pharmacol,2022,13:961817.
Memo
基金项目：国家中医药管理局中医药科学技术研究专项课题（GYZ-KJS-2021-001）；陕西省科技厅重点研发计划项目（S2021-YF-ZDCXL-ZDLSF-0011;2020ZDLSF05-14)；陕西省中医药管理局中西医结合临床协作创新项目(2020-ZXY-002)；陕西中医药大学附属医院中医临床基地建设项目(2020LCJD003;2020LCJD007)