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[1] WANG Ting LIU Weihai ZHANG Pan WANG Yuying ZOU Junbo MA Zhanping LIU Jiping WANG Bin WANG Chuan,.Discussion of Active Components and Targets of Zhongyan Yifei Jiedu Decoction in Prevention and Treatment of COVID-19 Based on Network Pharmacology and Molecular Docking [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2023, (02): 1-8. [doi: 10.13424/j.cnki.jsctcm.2023.02.001 ]

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Discussion of Active Components and Targets of Zhongyan Yifei Jiedu Decoction in Prevention and Treatment of COVID-19 Based on Network Pharmacology and Molecular Docking

Journal of Shaanxi University of Traditional Chinese Medicine[ISSN: 2096-1340/ CN: 61-1501/R] Volumes & Issues: 2023 02 pagination: 1-8 Column: Publication date: 2023-05-13

Article number:: 2096-1340(2023)02-0001-08

Author(s):: WANG Ting ¹ LIU Weihai ² ZHANG Pan ¹ WANG Yuying¹ ZOU Junbo¹ MA Zhanping³ LIU Jiping ¹ WANG Bin¹ WANG Chuan¹; 1.Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;
2 Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China;
3.Shaanxi Provincial Hospital of Chinese Medicine,Xian 710003,China

Keywords:: Key words： Zhongyan Yifei Jiedu Decoction; Network pharmacology; COVID-19; Chinese herbal; Molecular docking

ZTFLH:: R254.2

DOI:: 10.13424/j.cnki.jsctcm.2023.02.001

Code:: A

Abstract:: Abstract： Objective To explore the components and mechanism of Zhongyan Yifei Jiedu Decoction in the prevention and treatment of COVID-19 based on network pharmacology and molecular docking.Methods TCMSP database was used to search the main components and targets of Zhongyan Yifei Jiedu Decoction;Cytascape constructs drug-active component-target network diagram;The same target protein of Zhongyan Yifei Jiedu Decoction and COVID-19 was analyzed for GO function enrichment and KEGG pathway enrichment;Molecular docking was used to study its binding activity.Results Zhongyan Yifei Jiedu Decoction screened 176 potential active ingredients and 280 corresponding targets,69 of which were closely related to diseases;The enrichment analysis of target pathway showed that Zhongyan Yifei Jiedu Decoction mainly concentrated on viral infection and inflammatory signal pathway.Conclusion Zhongyan Yifei Jiedu Decoction may have potential preventive and therapeutic effects on COVID-19 through anti-inflammation and anti-virus.

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Memo

基金项目：国家自然科学基金项目（81800401）；陕西省教育厅一般专项项目（22JK0348）；陕西省科技厅一般项目（2022SF-207）；陕西中医药大学附属医院院级项目（2020MS019）

Last Update: 2023-03-27