[1] ZHAO Lifeng XIAO Jianqiang LU Xuejing,.Characteristics of Retinal Blood Oxygen Saturation in Bama Miniature Pigs with Excess Heat Syndrome [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2022, (06): 86-90. [doi: 10.13424/j.cnki.jsctcm.2022.06.017]
Characteristics of Retinal Blood Oxygen Saturation in Bama
Miniature Pigs with Excess Heat Syndrome
- Article number:
- 2096-1340(2022)06-0086-05
- Keywords:
- Excess heat syndrome; Bama miniature pig animal model; Retinal vessels; Blood oxygen saturation; Change
- ZTFLH:
- R276.7
- Code:
- A
- Abstract:
- Objective To investigate the effect of the animal model of excess heat syndrome of traditional Chinese medicine (TCM) on the blood oxygen saturation of retinal vessels in the fundus.Methods Twelve male and female Bama miniature pigs were randomly divided into two groups:the heat excess group and the normal group.The dose of mg·kg-1(50% concentration) was injected into the lateral side of the root of the right hind leg once.The normal group did not do any treatment.After the body temperature rose，the images of retinal fundus blood vessels in the two groups were collected by using a blood oxygen monitor (Oxymap).The matching software was used to analyze the blood oxygen saturation of retinal vessels.Results The ratio of arterial and venous oxygen saturation (SaO2/SvO2) increased in the real heat model group （P＜0.05）.The changes of arterial oxygen saturation (SaO2)，arteriovenous oxygen saturation difference (SaO2-SvO2) and arteriovenous oxygen saturation ratio (SaO2/SvO2) in the excess heat model group before and after modeling were higher than those in the normal group (P＜0.05).Conclusion The retinal microcirculation of Bama miniature pig is characterized by high oxygen consumption and metabolism under the condition of excess heat.
References:
［1］先永利,戴云,高椿明,等.双波长视网膜血氧测量系统［J］.光电工程,2016,43(6):68-74,82.
［2］葛坚,王宁利.眼科学［M］.3版.北京:人民卫生出版社,2015:321-322.
［3］Hardarson SH,Stefánsson E.Retinal oxygen saturation is altered in diabetic retinopathy［J］.The British Journal of Ophthalmology,2012,96(4):560-563.
［4］Hammer M,Vilser W,Riemer T,et al.Diabetic patients with retinopathy show increased retinal venous oxygen saturation［J］.Graefe's Archive for Clinical and Experimental Ophthalmology=Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie,2009,247(8):1025-1030.
［5］乐毅.糖尿病性视网膜病变和Vogt-小柳原田综合征视网膜血管血氧饱和度的研究［D］.天津:天津医科大学,2016.
［6］Zong Y,Lin LL,Yi CX,et al.Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages［J］.Graefe's Archive for Clinical and Experimental Ophthalmology,2016,254(2):243-252.
［7］Hardarson SH.Retinal oximetry［D］.Reykjavik:University of Iceland,2013.
［8］肖建强.实热证动物模型小型猪视网膜血管血氧饱和度检测［D］.成都:成都中医药大学,2017.
［9］胡金亮,李建生,余学庆.中医证候诊断标准研究背景与现状［J］.河南中医学院学报,2005,20(3):77-79.
［10］王楷,侯雨君,宋玮,等.泄泻中医证候动物模型研究进展［J］.中国实验动物学报,2021,29(6):823-829.
［11］彭百承,李萍,甄丹丹,等.清热解毒剂对内毒素所致家兔发热的影响［J］.中国实验方剂学杂志,2010,16(15):166-167.
［12］贺福元,邓凯文,罗杰英,等.中药四性研究现状与设想［J］.中国实验方剂学杂志,2008,14(8):72-75.
［13］杨鸿志,梁月华,任红.温热药(附子、干姜、肉桂)复方及小复方对交感神经、肾上腺、TSH、LH等的影响［J］.中国中药杂志,1992,17(11):688-690,704.
［14］徐建广,顾玉东.失神经支配骨骼肌退变组织形态学及电生理实验研究［J］.中国修复重建外科杂志,1999,13(4):202-205.
［15］谢静涛,黎敬波,周黎华.肺胃寒热证患者经穴辐射热的检测研究［J］.中国中医药科技,1997,4(3):139-140.
［16］梅雪,李建生,张艳霞.毒素清对肺炎痰热证大鼠肺组织炎症细胞因子的影响［J］.中国实验方剂学杂志,2011,17(5):153-156.
［17］谢竹藩,唐子进,马珩.从尿中儿茶酚胺及cAMP、cGMP的排出量探讨中医寒证、热证的本质［J］.中西医结合杂志,1986,6(11):651-654,643.
［18］王笑丹,张培彤.中医证候分层诊断模式及标准初探［J］.中华中医药杂志,2017,32(3):1209-1213.
［19］官宗华,宋捷民.中医实热证的研究及改进设想［J］.中国实验方剂学杂志,2012,18(22):349-352.
［20］徐志伟,陈群,孙琪,等.中医热证实质研究［J］.中国比较医学杂志,2009,19(3):53-56.
［21］张厚检,葛倩敏,邵毅.视网膜微循环检测技术及其临床应用［J］.国际眼科杂志,2020,20(11):1898-1901.
［22］孙安会,袁肇凯,夏世靖,等.中医证候系统生物学研究的现状和展望［J］.中华中医药杂志,2016,31(1):200-204.
［23］韩晨霞.基于线粒体生物合成探讨中枢疲劳的中医证候及生物学机制［D］.北京:北京中医药大学,2017.
［24］黄仲羽,刘凤斌.基于多维计算机自适应测试的中医证候量化方法学探索［J］.时珍国医国药,2018,29(1):234-236.
［25］孙喜灵,郑秋生,于东林,等.中医证候理论内蕴的数学逻辑关系研究:兼论“证素”研究的伪命题特征［J］.世界科学技术-中医药现代化,2015,17(6):1274-1279.
Memo
国家重大科学仪器设备开发专项（2013YQ490859）