[1] JIANG Xin WANG Yiping,.Clinical study of Treatment of Uremic Restless Legs Syndrome in Dialysis Patients with Chinese Medicine Foot Bath Combined with Piribedil [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2022, (04): 95-100. [doi: 10.13424/j.cnki.jsctcm.2022.04.021]
Clinical study of Treatment of Uremic Restless Legs
Syndrome in Dialysis Patients with Chinese
Medicine Foot Bath Combined with Piribedil
- Article number:
- 2096-1340(2022)04-0095-06
- Keywords:
- Key words：Chinese medicine foot bath; Restless legs syndrome; Piribedil; Dialysis; Sleep quality
- ZTFLH:
- R459.5
- Code:
- A
- Abstract:
- Abstract：Objective To observe the clinical efficacy of Chinese medicine foot bath combined with piribedil in the treatment of uremic restless legs syndrome (u-RLS) in dialysis patients. Methods 60 dialysis patients with restless legs syndrome (including hemodialysis and peritoneal dialysis) were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was given piribedil 50 mg orally before going to bed，while the treatment group was given traditional Chinese medicine foot bath on the basis of the control group for 4 weeks. The scores of international restless legs syndrome self rating scale (IRLSSG)，Pittsburgh sleep quality index (PSQI) and clinical efficacy were compared between the two groups. The adverse reactions of drugs and related blood biochemical indexes were observed during the treatment. Results The total effective rate was 86.67% (26/30) in the treatment group and 60.00% (18/30) in the control group. There was significant difference between the two groups (P<0.05)；Compared with that before treatment，IRLSSG and PSQI in the treatment group and the control group decreased (P<0.05)，and the decrease in the treatment group was more significant than that in the control group；There were no significant changes in serum calcium (Ca)，serum phosphorus (P) and parathyroid hormone (iPTH) in the two groups before and after treatment. There was no significant difference between the two groups (P>0.05)；There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Traditional Chinese medicine foot bath combined with piribedil has a significant effect on dialysis patients with restless legs syndrome，which can significantly alleviate clinical symptoms and improve sleep quality. Abstract：Objective To observe the clinical efficacy of Chinese medicine foot bath combined with piribedil in the treatment of uremic restless legs syndrome (uRLS) in dialysis patients. Methods 60 dialysis patients with restless legs syndrome (including hemodialysis and peritoneal dialysis) were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was given piribedil 50 mg orally before going to bed，while the treatment group was given traditional Chinese medicine foot bath on the basis of the control group for 4 weeks. The scores of international restless legs syndrome self rating scale (IRLSSG)，Pittsburgh sleep quality index (PSQI) and clinical efficacy were compared between the two groups. The adverse reactions of drugs and related blood biochemical indexes were observed during the treatment. Results The total effective rate was 86.67% (26/30) in the treatment group and 60.00% (18/30) in the control group. There was significant difference between the two groups (P<0.05)；Compared with that before treatment，IRLSSG and PSQI in the treatment group and the control group decreased (P<0.05)，and the decrease in the treatment group was more significant than that in the control group；There were no significant changes in serum calcium (Ca)，serum phosphorus (P) and parathyroid hormone (iPTH) in the two groups before and after treatment. There was no significant difference between the two groups (P>0.05)；There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Traditional Chinese medicine foot bath combined with piribedil has a significant effect on dialysis patients with restless legs syndrome，which can significantly alleviate clinical symptoms and improve sleep quality. Abstract：Objective To observe the clinical efficacy of Chinese medicine foot bath combined with piribedil in the treatment of uremic restless legs syndrome (uRLS) in dialysis patients. Methods 60 dialysis patients with restless legs syndrome (including hemodialysis and peritoneal dialysis) were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was given piribedil 50 mg orally before going to bed，while the treatment group was given traditional Chinese medicine foot bath on the basis of the control group for 4 weeks. The scores of international restless legs syndrome self rating scale (IRLSSG)，Pittsburgh sleep quality index (PSQI) and clinical efficacy were compared between the two groups. The adverse reactions of drugs and related blood biochemical indexes were observed during the treatment. Results The total effective rate was 86.67% (26/30) in the treatment group and 60.00% (18/30) in the control group. There was significant difference between the two groups (P<0.05)；Compared with that before treatment，IRLSSG and PSQI in the treatment group and the control group decreased (P<0.05)，and the decrease in the treatment group was more significant than that in the control group；There were no significant changes in serum calcium (Ca)，serum phosphorus (P) and parathyroid hormone (iPTH) in the two groups before and after treatment. There was no significant difference between the two groups (P>0.05)；There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Traditional Chinese medicine foot bath combined with piribedil has a significant effect on dialysis patients with restless legs syndrome，which can significantly alleviate clinical symptoms and improve sleep quality.
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Memo
基金项目：国家自然科学基金面上项目(81673931)；安徽中医药领军人才项目［中医药发展秘(2018)23号］