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[1] DING TaoWANG Han,.Effects of Noninvasive Diagnosis on Evaluation of Hepatolenticular Degeneration and Cirrhosis and Analysis of TCM Syndrome Types [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2021, 44(05): 74-78. [doi: 10.13424/j.cnki.jsctcm.2021.05.015]

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Effects of Noninvasive Diagnosis on Evaluation of Hepatolenticular Degeneration and Cirrhosis and Analysis of TCM Syndrome Types

Journal of Shaanxi University of Traditional Chinese Medicine[ISSN: 2096-1340/ CN: 61-1501/R] Volumes & Issues: 44 2021 05 pagination: 74-78 Column: Publication date: 2021-09-30

Article number:: 2096-1340(2021)05-0074-05

Author(s):: DING Tao¹WANG Han²; 1.Anhui University of Traditional Chinese Medicine,Hefei 230031,China;
2.The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China

Keywords:: Hepatolenticular degeneration; Transient elastography; 4 items hepatic fibers; ChildPugh; TCM syndrome type

ZTFLH:: R256.42

DOI:: 10.13424/j.cnki.jsctcm.2021.05.015

Code:: A

Abstract:: Objective To investigate the role of liver transient elastography (FS) and serum liver fibrosis indexes ①hyaluronic acid (HA),②laminin (LN),③type Ⅲ procollagen Nterminal peptide (PⅢNP) and ④collagen Ⅳ (Ⅳ- C) in the evaluation of liver cirrhosis and the analysis of TCM syndrome types.Methods The subjects were 112 patients with hepatolenticular cirrhosis treated for the first time in Anhui Hospital of traditional Chinese medicine from June 2019 to January 2020.In the evaluation of the degree of liver cirrhosis,the three levels A,B and C of liver cirrhosis according to cirrhosis Child Pugh.30 healthy subjects in the control group were selected.The subjects in each group were examined by transient elastic imaging of liver and 4 indexes of serum liver fibrosis.The correlation between the indexes of each group and Child Pugh score was analyzed; In the analysis of TCM syndrome types,WD patients were divided into groups according to TCM syndrome types,and the indexes of each group were compared.Results The levels of LSM and serum HA,LN,PⅢNP and Ⅳ-C in Child Pugh grade A,B and C groups of WD cirrhosis were significantly higher than those in the control group (P<0.05).Except PⅢNP,the four indexes of serum liver fibrosis increased significantly with the increase of Child Pugh grade of cirrhosis (P<0.05).Ⅳ-C was positively correlated with the total score of Child Pugh grade (P<0.05).In the analysis of syndrome types,the indexes LSM,HA,LN and Ⅳ-C of patients with spleen and kidney Yang deficiency syndrome were higher than those of patients with damp heat accumulation syndrome and phlegm and blood stasis syndrome (P<0.05).Conclusion The higher the child Pugh grade,the higher the four indexes of serum liver fibrosis and the increase of LSM in patients with hepatolenticular cirrhosis.The indexes of patients with different syndrome types are different,and the patients with spleen and kidney Yang deficiency syndrome are significantly higher than other syndrome types.Liver transient elastography and serum liver fibrosis index can be used as effective means to evaluate the degree of liver cirrhosis and analyze TCM syndrome types.

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Memo

基金项目：国家中医药管理局区域中医（专科）诊疗中心建设项目（20180712）

Last Update: 2021-09-23