[1] Wang Yaguo, Wang Guanlin, Dong Bo, et al. Effect of Gufusheng on Clinical Efficacy and Hemorheology of Patients with Osteonecrosis [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2020, (5): 70-75. [doi: 10.13424/j.cnki.jsctcm.2020.05.018]
Effect of Gufusheng on Clinical Efficacy and Hemorheology of Patients with Osteonecrosis
- Article number:
- 2096-1340(2020)05-0070-06
- Keywords:
- TCM; CAG; syndrome differentiation; review; distention and fullness; noisy; stomachache
- ZTFLH:
- R681.8
- Code:
- A
- Abstract:
- Objective Combining with the detection and analysis of hemorheology indexes, to evaluate the clinical curative effect and hemorheology of osteonecrosis before and after treatment to explore the clinical effect of Gufusheng and hemorheology of patients in the early and middle stage as well as its possible mechanism, providing the basis for the clinical application of the prescription. Methods 68 patients with osteonecrosis were divided into treatment group and control group according to their registration time with 34 cases in each group. The treatment group was treated with Chinese medicine Gufusheng, and the control group was treated with alendronate sodium tablets. The VAS score of hip joint pain ( rest pain and activity pain) , Harris score of hip joint and hemorheology related indexes were observed before and after treatment in each group. Result ① The VAS scores of hip joint pain at rest and activity in the two groups after treatment were lower than those before treatment with significant difference ( P < 0. 05) ; The VAS score of the treatment group decreased more significantly, and the difference between the two groups was statistically significant ( P < 0. 05) . ② Harris scores and total scores of hip joint ( pain, daily activities and walking ability, deformity, joint range of motion) and total scores of the two groups after treatment were higher than those before treatment with statistical significance ( P < 0. 05) . The Harris scores and total scores in the treatment group were slightly higher than those in the control group with statistical significance ( P < 0. 05) . ③ After treatment, the whole blood viscosity 200 ( 1 / s) , TK, FB, ESR - K, re ( erythrocyte aggregation index) , HC ( Casson viscosity) , HRV, LRV, η P, ESR, EPT ( erythrocyte electrophoresis time) of the two groups were decreased after treatment ( P < 0. 05) , and the decrease in the treatment group was more obvious, the difference between the two groups was statistically significant ( P < 0. 05) . However, the whole blood viscosity 3 ( 1 / s) , 30( 1 / s) , HCT, γ C, IR, MRV had no significant changes after treatment ( P > 0. 05) . Conclusion Gufusheng can relieve the pain of patients with avascular necrosis of the femoral head in the early and middle stage, improve the joint activity limitation and other discomfort symptoms, and also can improve some indexes of hemorheology。
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Memo
基金项目:国家中管局科研专项(JDZX2015280);全国名老中医药专家传承工作室建设项目(国中医药人教发[2018]134号);陕西省教育厅计划项目(18JK0226);陕西省重点科技创新团队项目(2013KJT-26);关中李氏骨伤流派传承工作室项目(陕中医药发[2018]40号)
通信作者:王官林(1980-)男,硕士,副主任医师,研究方向:中医骨伤?E_mail:924643331@QQ.com