[1] Ou Li, Zuo Yangjie, Chen Jiali, et al. Effects of Ｒadix Ｒehmanniae Preparata and Astragalus Membranaceus on Bone Metabolism in Ovariectomized Ｒats [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2018, (03): 71-74. [doi: 10．13424/j．cnki．jsctcm．2018．03．023]
Effects of Ｒadix Ｒehmanniae Preparata and Astragalus Membranaceus on Bone Metabolism in Ovariectomized Ｒats
- Article number:
- 2096－1340(2018)03－0071－04
- Keywords:
- radix rehmanniae preparata; astragalus membranaceus; postmenopausal osteoporosis; bone metabolism
- ZTFLH:
- Ｒ285. 5
- Code:
- A
- Abstract:
- To observe the effects of radix rehmanniae preparata and astragalus membranaceus on bone metabolism and regulation approach in ovariectomized rats． Method: After ovariectomy，60 rats were randomly divided into six groups: astragalus membranaceus group，radix rehmanniae preparata group，radix rehmanniae preparata and as- tragalus membranaceus group，estrogen group，model control group and blank control group． Gavage with corresponding drugs was given to the groups for 16 weeks． Then the animals were sacrificed and the serum and bone tissues were taken out，the bone metabolism and related indicators of Wnt pathway expression were detected． Ｒesult: Compared with the model group，the level of serum TＲACP in the rats of Ｒadix Astragali group significantly decreased ( P ＜ 0． 05) ，and the level of IGF － 1 increased significantly ( P ＜ 0． 05) ，the expression level of Wnt2，LＲP5 and beta － catenin mＲNA in the bone tissue of rats increased significantly ( P ＜ 0． 01) ． Conclusion: The compatibility of radix rehmanniae preparata with astragalus membranaceus can activate the Wnt /LＲP/β － catenin signaling pathway，reduce the activity of osteoclasts， promote the formation of osteoblasts，and thus achieve the purpose of regulating bone metabolism．
References:
[1]Zhang SW，Li SH，Fan CH． Advance of TCM syndrome differentiation and treatment in primary osteoporosis［J]． Chinese Journal of Osteoporosis，2013，19 ( 12 ) : 1318 － 1322．
[2]Qi W，Yan YB，Lei W，et al． Prevention of disuse osteo- porosis in rats by Cordyceps sinensis extract ［J]． Osteo- poros Int，2012，23( 9) : 2347 － 2357．
[3]Zhao X，Wu ZX，Zhang Y，et al． Anti － osteoporosis ac- tivity of Cibotium barometz extract on ovariectomy － in- duced bone loss in rats［J]． J Ethnopharmacol，2011，137 ( 3) : 1083 － 1088．
[4]Cao PC，Xiao WX，Yan YB，et al． Preventive effect of crocin on osteoporosis in an ovariectomized rat model［J]． Evid BasedComplement Alternat Med，2014，( 8) : 1 － 11．
[5]欧莉，曾小红，赵鹏． 熟地、黄芪为主药治疗绝经后骨
质疏松症的临床观察［J]． 北京中医药，2011，30 ( 8) :
605 － 606．
[6]欧莉，卫培峰，苗彦霞． 黄芪配伍熟地对去势大鼠骨
质疏松的治疗作用［J]． 中国药理学与毒理学杂志， 2013，27 ( 3) : 363 － 366．
[7]欧莉，曾小红，卫培峰． 黄芪配伍熟地对去势大鼠骨
矿含量及生物力学影响的实验研究［J]． 中国医院药学
杂志，2013，34 ( 8) : 530 － 532．
[8] Ｒoy B，Curtis ME，Fears LS，et al． Molecular mecha- nisms of obesity － in － duced osteoporosis and muscle atro- phy［J]． Front Physiol，2016，7 ( 9) : 439 － 457．
[9]Du L，Nong MN，Zhao JM，et al． Polygonatum sibiricum polysaccharide inhibits osteoporosis by promoting osteo- blast formation and blocking osteoclas － togenesis through Wnt /beta － catenin signalling pathway［J]． Sci Ｒep， 2016，6( 8) : 32261 － 32263．
[10] Shi CD，Yuan PW，Yang XH． Observation of granule of kang － shu jian － gu on postmenopausal osteoporosis on 40 cases［J]． Shanxi J of TCM，2012，28( 1) : 16 － 17．
[11]徐轶尔，孙贵才，于雪峰，等． Wnt 信号传导途径与骨
质疏松［J]． 中国骨质疏松杂志，2016，22 ( 2 ) : 228 － 232．
Memo
基金项目: 陕西省科技厅社发项目 ( 2014K11 － 02 － 04 － 10)
通讯作者: 欧莉( 1980 － ) ，女，博士，副教授，主要研究方向: 中药药对配伍研究。E － mail: 23127438@ qq． com 收稿日期: 2018 － 02 － 08 编辑: 文颖娟