[1] SU Hongxia DUAN Yuhong ZHANG Yan GAO Yan BAI Xian CHEN Yao LEI Ting,.Effect of Yiqi Guben Decoction Combined with Exercise Intervention on the Regulation of Blood Glucose in diabetes Model Rats [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2024, (05): 24-29. [doi: 10.13424/j.cnki.jsctcm.2024.05.004]
Effect of Yiqi Guben Decoction Combined with Exercise Intervention on the Regulation of Blood Glucose in diabetes Model Rats
- Article number:
- 2096-1340(2024)05-0024-06
- Keywords:
- Key words： Diabetes; Exercise intervention; Blood glucose homeostasis; Yiqi Guben decoction; Qi tonifying and Yin nourishing method
- ZTFLH:
- R285.5
- Code:
- A
- Abstract:
- Abstract： Objective To explore the effect of Yiqi Guben Decoction on blood glucose regulation in diabetes model rats,and further study its effect on the level of blood glucose regulating hormone.Methods The model of diabetes rats was established with high-fat diet and streptozotocin.The experiment was set up with exercise group,Yiqi Guben decoction group and Yiqi Guben decoction+exercise group.The effects of exercise group,Yiqi Guben decoction+exercise group on the general situation,fasting blood glucose (FBG),fasting insulin level,glucagon level,cortisol and liver glycogen level of diabetes rats were observed.Results Compared with the model group,the exercise group,Yiqi Guben decoction group,and Yiqi Guben decoction+exercise group showed significant reductions in serum levels of glucagon and cortisol in FBg,with statistical significance (P<0.01,P<0.05).Fasting insulin and liver glycogen levels increased,with statistical significance (P<0.01,P<0.05).The Yiqi Guben decoction+exercise group had a synergistic effect on changes in FBg,fasting insulin levels,glucagon levels,cortisol and liver glycogen levels in rats (P<0.05).Conclusion Yiqi Guben decoction combined with exercise intervention can effectively improve the general state of diabetes rats,reduce the blood sugar of diabetes rats and maintain their blood sugar homeostasis,and have a recovery effect on the function of pancreatic islets of diabetes rats;This may be related to the fact that Yiqi Guben decoction increases insulin secretion,reduces and regulates serum glucagon and cortisol secretion,and increases liver glycogen content.
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Memo
基金项目：咸阳市科技局科研计划项目（2019k02-95）