[1] ZHOU Chunyu SHAN Jingyi JIANG Fengru SUN Boyun YUAN Jianye,.NLRP6 Inflammasome and Inflammatory Bowel Disease [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2024, (04): 1-6. [doi: 10.13424/j.cnki.jsctcm.2024.04.001]
NLRP6 Inflammasome and Inflammatory Bowel Disease
- Article number:
- 2096-1340(2024)04-0001-06
- Keywords:
- Key words： Nucleotide-binding oligomerization domain-like receptor protein 6; Inflammatory corpuscles; Inflammatory bowel disease; Interleukin; Intestinal microbiota
- ZTFLH:
- R364.5
- Code:
- A
- Abstract:
- Abstract： Nucleotide-binding oligomerization domainlike receptor protein (NLRP) 6 inflammasomes are composed of NLRP6，caspase-1，and apoptosis related spot like proteins.NLRP6 is the core protein that constitutes the NLRP6 inflammasome，consisting of the NACHT domain in the middle of the hot protein domain at the amino end and the leucine rich repetitive sequence domain at the carboxyl end.Due to NLRP6 being a relatively new inflammasome，many details of its role in the pathophysiology of the body remain to be determined.Currently，it is known that NLRP6 inflammasomes play an important role in the development of chronic inflammation，autoimmune syndrome，and metabolic diseases.Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease closely related to immune dysfunction，and has become a widely prevalent global epidemic in developed and developing countries.However，the detailed pathogenesis of IBD still needs to be thoroughly revealed.An increasing amount of evidence suggests that NLRP6 inflammasome is closely related to the onset of IBD.The article provides a review of current research progress in related fields.
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Memo
基金项目：国家自然科学基金项目（82104743）