[1] LIU Yaxiao LI Xinzhuo TANG Jiamei ZHANG Huawei JIANG YiZHANG Dongdong SONG Xiaomei WANG Wei LI Yuze,.Research Progress on Chemical Components and Pharmacological Effects of Sedum Notoginseng [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2024, (03): 21-33. [doi: 10.13424/j.cnki.jsctcm.2024.03.003]
Research Progress on Chemical Components and Pharmacological Effects of Sedum Notoginseng
- Article number:
- 2096-1340(2024)03-0021-13
- Keywords:
- Key words：Sedum notoginseng; Chemical composition; Pharmacological effects; Flavonoids; Terpenes; Phenols
- ZTFLH:
- R285.5
- Code:
- A
- Abstract:
- Abstract：Sedum notoginseng is a plant of the Sedum family,and its entire herb can be used as medicine.It was once included in the 1977 edition of the Chinese Pharmacopoeia and is also one of the “Taibai Seven Medicines”.Research has shown that Sedum notoginseng has a certain therapeutic effect on various diseases such as bleeding,cardiovascular and cerebrovascular diseases,and acute joint sprains.We are currently reviewing relevant literature at home and abroad to review the chemical components of Sedum notoginseng,such as flavonoids,terpenoids,phenols,and its pharmacological effects such as hemostasis,antibacterial,anti-inflammatory,and antioxidant properties.This provides a reference for further in-depth research and development of this medicinal herb in the future.
References:
［1］宋小妹,刘海静.太白七药研究与应用［M］.北京:人民卫生出版社,2011.
［2］中国科学院中国植物志编辑委员会.中国植物志［M］.北京:科学出版社,2010.
［3］韩瑞杰,赵晨,陈豪杰,等.景天三七化学成分研究［J］.中华中医药杂志,2021,36(7):4223-4226.
［4］XU TY,WANG ZH,LEI TL,et al.New flavonoid glycosides from Sedum aizoon L.［J］.Fitoterapia,2015,101:125-132.
［5］KORULKIN DY.Chemical Composition of Certain Sedum Species of Kazakhstan［J］.Chemistry of Natural Compounds,2001,37(3):219-223.
［6］韩炜,李明晓,吕重宁,等.景天三七茎叶的化学成分研究［J］.中国医药导报,2017,14(27):33-36.
［7］张晶晶,王晶,薛娇,等.费菜茎叶的化学成分［J］.沈阳药科大学学报,2010,27(8):635-638.
［8］LIN ZC,FANG YJ,HUANG AY,et al.Chemical constituents from Sedum aizoon and their hemostatic activity.［J］.Pharmaceutical Biology,2014,52(11):1429-1434.
［9］于志斌,杨广义,吴霞,等.救心草的化学成分研究［J］.天然产物研究与开发,2007,19(1):67-69.
［10］李乔,于洋,李明晓,等.费菜根茎化学成分的分离与鉴定［J］.中国现代中药,2020,22(3):353-357.
［11］熊燕,杜彩霞,段玉书,等.黔产景天三七的化学成分及药理活性研究［J］.中草药,2019,50(22):5404-5410.
［12］贾凌云,徐昙烨,王晶,等.费菜茎叶化学成分的分离与鉴定(Ⅱ)［J］.沈阳药科大学学报,2014,31(9):673-676.
［13］林珠灿,黄华花,陈达炜,等.养心草宁心安神活性部位的化学成分研究［J］.中华中医药杂志,2011,26(12):3000-3002.
［14］马娇.费菜总黄酮的分离与抗氧化活性研究［D］.绵阳:西南科技大学,2019.
［15］LUO QY,LI WL,WU LQ.Acylated flavonol glycosides from Sedum aizoon［J］.Chemistry of Natural Compounds,2012,48(1):23-25.
［16］MARIA W.Polyphenolic Compounds from sedum aizoon L.［J］.Acta Pol.Pharm,1996,53(3):225-227.
［17］LI WL,LUO QY,WU LQ,et al.Two new flavonol glycosides from Sedum aizoon L［J］.HETEROCYCLES,2011,83(1):135.
［18］林珠灿,邱麒,房英娟,等.景天三七乙酸乙酯部位化学成分研究［J］.中药材,2014,37(10):1792-1795.
［19］LI WL,LUO QY,WU LQ.Two new prenylated isoflavones from Sedum aizoon L［J］.Fitoterapia,2011,82(3):405-407.
［20］陈迩东,王小明,巩丽丽,等.气相色谱-质谱联用法分析费菜地上部分挥发性成分［J］.山东中医杂志,2014,33(6):491-492.
［21］李忠红,胡浩彬,廖学威,等.气相色谱-质谱法分析景天三七挥发性成分［J］.医药导报,2007,26(10):1228-1229.
［22］钱宇欣,李燕,郭东贵.景天三七挥发油化学成分分析［J］.贵阳中医学院学报,2018,40(1):47-49.
［23］郭素华,车苏容,竺叶青,等.养心草挥发油化学成分气相-质谱联用技术分析［J］.中华中医药杂志,2006,21(11):689-690.
［24］赵秀玲,朱帅.救心菜精油中主要成分的GC-MS分析［J］.贵州师范大学学报(自然科学版),2017,35(2):65-69.
［25］李乔,于洋,徐昙烨,等.费菜正丁醇部位化学成分的分离与鉴定［J］.沈阳药科大学学报,2020,37(3):240-245.
［26］李卫林,荆云,罗秋燕,等.景天三七的化学成分研究［J］.新乡医学院学报,2008,25(6):558-561.
［27］KRASNOV EA,PETROVA LV.Arbutin in some plants of the genus Sedum［J］.Chemistry of Natural Compounds,1970,6(4):491.
［28］曹乃锋.费菜和地锦草生物活性成分研究［D］.开封:河南大学,2011.
［29］KRASNOV EA,PETROVA LV,BEKKER EF.Alkaloids of sedum species［J］.Khim.Prir.Soedin,1977,10(4):585.
［30］冀涛.MMP-9在土三七致肝窦阻塞综合征中的表达及意义［D］.杭州:浙江大学,2009.
［31］马娇,高蕾,施月,等.景天三七总黄酮的纯化、自由基清除活性及初步鉴定［J］.食品工业科技,2019,40(4):207-213,219.
［32］SHNIAKINA GP.Qualitative composition of fenolic compounds of Far East species of Sedum L［J］.Rastitelnye Resursy,1979.
［33］陈克克,强毅.费菜不同部位脂溶性成分的GC-MS比较［J］.中国实验方剂学杂志,2017,23(20):77-81.
［34］强毅,李江林,王晟昱,等.费菜不同部位氨基酸组成及含量分析［J］.光谱实验室,2013,30(2):1000-1003.
［35］王立业,王艳艳,吴玉琦,等.河南产景天三七根、茎、花、叶中钙含量的测定［J］.洛阳师范学院学报,2021,40(11):14-17.
［36］张九东,徐伟君,刘君侠.九种野菜在不同贮藏环境中维生素C含量的变化［J］.陕西农业科学,2022,68(4):67-69.
［37］江苏南通中成药厂中草药研究小组.草药景天三七止血功效的临床观察［J］.新医学,1971,2(3):14-15.
［38］江苏省南通中成药厂.止血药景天三七糖浆［J］.中草药通讯,1971,2(3):50.
［39］许智超,温燕华,李美娟,等.景天三七对阿司匹林大鼠的止血活血功效及作用机制研究［J］.时珍国医国药,2016,27(1):84-85.
［40］白以琳,孙涛,王颖娴,等.景天三七对阿司匹林所致胃出血大鼠血小板及血管壁功能的影响［J］.检验医学,2016,31(2):131-134.
［41］刘芷伊,王颖娴,孙涛,等.景天三七对胃出血大鼠的止、凝血疗效观察及最佳剂量筛选［J］.中国中医药现代远程教育,2015,13(13):142-144.
［42］陈卫琳,邱麒,林珠灿,等.养心草止血有效部位的筛选研究［J］.浙江中医药大学学报,2012,36(2):182-183.
［43］林珠灿.景天三七止血、抗炎物质基础与质量评价的研究［D］.南京:南京中医药大学,2014.
［44］张彦霞,乔海霞,单永强,等.景天三七醇提物体外抗菌作用的研究［J］.河北北方学院学报(自然科学版),2011,27(5):78-80.
［45］谭苹,姚丽芳,彭承秀.40种秦岭“七药”最低抑菌浓度的测试［J］.时珍国医国药,2001,12(6):484-485.
［46］强毅,王政军,陈克克,等.费菜多酚含量的测定及体外抗菌活性研究［J］.食品工业科技,2013,34(5):53-56.
［47］罗洁,王鸿飞,许凤,等.费菜不同组织总黄酮抗氧化与抑菌活性的研究［J］.天然产物研究与开发,2018,30(11):1957-1962,1970.
［48］WANG HX,XU F,ZHANG X,et al.Transcriptomic analysis reveals antibacterial mechanism of flavonoids from Sedum aizoon L.against Pseudomonas fragi［J］.Food Control,2022,134:108755.
［49］WANG J,CHI ZY,ZHAO K,et al.A transcriptome analysis of the antibacterial mechanism of flavonoids from Sedum aizoon L.against Shewanella putrefaciens［J］.World Journal of Microbiology & Biotechnology,2020,36(7):94.
［50］XU F,WANG CX,WANG HF,et al.Antimicrobial action of flavonoids from Sedum aizoon L.against lactic acid bacteria in vitro and in refrigerated fresh pork meat［J］.Journal of Functional Foods,2018,40:744-750.
［51］黄安玉.养心草水提乙酸乙酯部位止血和抗炎活性的筛选［D］.福州:福建中医药大学,2014.
［52］GONG JY,QIU SP,WENG QA,et al.Effect of different drying methods on phenolic compounds and antioxidant capacity in different fractions of Sedum aizoon L［J］.Journal of Food Processing and Preservation,2020,44(9):1-8.
［53］JIN CB,WEI XC,YANG SHL,et al.Microwave-assisted Extraction and Antioxidant Activity of Flavonoids from Sedum aizoon Leaves［J］.Food Science and Technology Research,2017,23(1):111-118.
［54］QI X,LU XT,SUN XH,et al.The regulatory effect of total flavonoids of Sedum aizoon L.on oxidative stress in type 1 diabetic mice［J］.Current Research in Food Science,2022,5:1140-1147.
［55］路欣彤.养心菜总黄酮对高血糖小鼠氧化应激的调节作用研究［D］.延吉:延边大学,2022.
［56］刘晔峰,马峥嵘,吴晓琴,等.养心草的有效成分及功能性化合物研究进展［J］.中华中医药杂志,2012,27(8):2135-2138.
［57］王佰灵,罗伦,邱婧然,等.景天三七总多酚提取工艺的优化及活性研究［J］.化学研究与应用,2021,33(8):1485-1493.
［58］陈惠卿,杨安平,任吉君,等.土三七总酚酸抗氧化活性的研究［J］.中医药导报,2013,19(11):78-79,82.
［59］王鸿飞,刘飞,徐超,等.费菜总黄酮调节血脂及对肝癌细胞增殖的作用［J］.中国食品学报,2013,13(4):23-27.
［60］付煜荣,薄爱华,孙犁,等.土三七对食管癌细胞超微结构的影响［J］.时珍国医国药,2008,19(2):368-369.
［61］LI MX,QI ZHY,HAO YM,et al.New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L.with Potential Antitumor Activity［J］.Molecules,2017,22(11):1859.
［62］丁琼.景天三七抗运动性疲劳的实验研究［D］.北京:首都体育学院,2019.
［63］任梦洁.景天三七对小鼠与人运动疲劳的预防作用研究［D］.北京:首都体育学院,2020.
［64］吴符火,刘雪梅,郭素华.养心草胶囊调血脂机制的实验研究［J］.中国中西医结合杂志,2006(2):131-134.
［65］朱博杰,潘天箫,黄子冬,等.景天三七抗动脉粥样硬化作用［J］.亚太传统医药,2023,19(1):41-44.
［66］黄睿.费菜多糖的免疫活性研究［D］.延吉:延边大学,2019.
［67］韩文东,薛爽,陈姜艳,等.景天三七对高血压的治疗作用及其有效成分分析［J］.名医,2022(7):42-44.
［68］张旭静,李攀,文泽军.CT与MRI对土三七致肝窦阻塞综合征的诊断价值［J］.临床心身疾病杂志,2020,26(6):124-126.
［69］耿雯倩,朱浩,杨鑫,等.肝窦阻塞综合征成功诊治1例报告［J］.临床肝胆病杂志,2023,39(2):397-400.
Memo
基金项目：陕西省科技厅重点研发计划项目(2022SF-254)；陕西中医药大学学科创新团队项目（2019-YL12）;陕西中医药大学一般项目（2021GP27）