[1] CHENG Chunya MA Yanzhu LI Ran WU Haixu SHAO Jing CUI Zhijia,.Research Progress and Development Status of Chemical Composition and Pharmacological Effects of Pollen [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2023, (03): 108-118. [doi: 10.13424/j.cnki.jsctcm.2023.03.022]
Copy

Research Progress and Development Status of Chemical Composition and Pharmacological Effects of Pollen

Journal of Shaanxi University of Traditional Chinese Medicine[ISSN: 2096-1340/ CN: 61-1501/R] Volumes & Issues: 2023 03 pagination: 108-118 Column: Publication date: 2023-05-31
Article number:
2096-1340(2023)03-0108-11
Author(s):
CHENG Chunya1 MA Yanzhu1 LI Ran1 WU Haixu1 SHAO Jing1; 2; 3 CUI Zhijia1; 2; 3
1.Gansu University of Chinese Medicine,Lanzhou 730000,China;
2.Northwest China Tibetan Medicine Provincial Collaborative Innovation Center,Lanzhou 730000,China;
3.Gansu Traditional Chinese Medicine Research Center,Lanzhou 730000,China
Keywords:
Key words： Pollen; Chemical composition; Pharmacological effects; Develop applications; Research progress
ZTFLH:
R282.71
DOI:
10.13424/j.cnki.jsctcm.2023.03.022
Code:
A
Abstract:
Abstract： With the widespread application of analytical techniques such as thin layer chromatography,highperformance liquid chromatography,and gas chromatographymass spectrometry,significant progress has been made in the analysis of pollen components and their pharmacological effects.Research has shown that flavonoids,phenols,polysaccharides,and other components in pollen are the main material basis for pollens pharmacological effects in antiinflammatory,antiviral,antitumor,antioxidant,liver protection,and cardiovascular disease prevention.In addition,pollen also contains various components such as proteins,amino acids,lipids,minerals,vitamins,and can be developed for use in various fields such as food,health,medicine,cosmetics,and feed processing,The development and utilization prospects are broad.Due to its good pharmacological effects and health value,the demand for pollen has been increasing in recent years.However,due to the lack of systematic basic research,many plant species of pollen have not been effectively utilized,which has become a key issue restricting the development of the pollen industry.This article reviews the achievements in the chemical composition,main pharmacological effects,and safety evaluation of pollen,and reviews and prospects the current development and utilization of pollen.Two directions for future research on pollen are proposed:firstly,to accelerate the identification of the applied varieties and effective components of pollen;The second is to strengthen the research on pollen quality standards,in order to provide theoretical basis for indepth research and development and utilization of pollen resources.

References:

［1］Kenel A,Zimmermann B.Chemical analysis of pollen by FTRaman and FTIR spectroscopies［J］.Frontiers in Plant Science,2020,11:352.
［2］Denisow B,DenisowPietrzyk M.Biological and therapeutic properties of bee pollen:a review［J］.Journal of the Science of Food and Agriculture,2016,96(13):4303-4309.
［3］张朵,闫荣玲,罗志威,等.山茶花花粉中稀土与重金属元素含量及花粉多糖的提取与生物活性研究［J］.天然产物研究与开发,2019,31(8):14181424.
［4］Shi PY,Geng QQ,Chen LF,et al.Schisandra chinensis bee pollen & apos;s chemical profiles and protective effect against H2O 2induced apoptosis in H9c2 cardiomyocytes［J］.BMC Complementary Medicine and Therapies,2020,20(1):274.
［5］李淑英,高洁,侯丽真,等.破壁对西藏高原油菜蜂花粉胃肠道消化吸收特性的影响［J］.食品科技,2020,45(10):76-81.
［6］Pascoal A,Rodrigues S,Teixeira A,et al.Biological activities of commercial bee pollens:Antimicrobial,antimutagenic,antioxidant and antiinflammatory［J］.Food and Chemical Toxicology,2014,63:233-239.
［7］戴承恩,何小平,郑芬芬,等.松花粉主要活性成分及保健作用的研究进展［J］.食品研究与开发,2019,40(8):212-219.
［8］Yang K,Wu D,Ye XQ,et al.Characterization of chemical composition of bee pollen in China［J］.Journal of Agricultural and Food Chemistry,2013,61(3):708-718.
［9］张金振,吴黎明,赵静,等.13种植物源蜂花粉蛋白质的营养学评价［J］.食品科学,2014,35(1):254-257.
［10］黄新球,杨有仙,卢焕仙,等.5种云南产蜂花粉矿质元素分析及蛋白质营养评价［J］.西南农业学报,2020,33(5):980-986.
［11］Yang SF,Wei K,Jia FJ,et al.Characterization and biological activity of Taishan Pinus massoniana pollen polysaccharide in vitro［J］.PLoS One,2015,10(3):e0115638.
［12］周望庭,米佳,禄璐,等.枸杞蜂花粉主要化学成分与抗氧化作用［J］.食品科学,2018,39(4):219-224.
［13］耿兴敏,裘建宇,王良桂.球根花卉花粉萌发过程中糖类物质及相关酶活性的变化［J］.南京林业大学学报(自然科学版),2013,37(4):34-38.
［14］李娟,钟平娟,万仁口,等.荞麦蜂花粉多糖的分离纯化及结构鉴定［J］.食品工业科技,2020,41(12):35-40.
［15］王博,张梦珊,张中玉,等.菊花蜂花粉多糖的分离纯化及抗肿瘤活性研究［J］.食品工业科技,2016,37(5):358-360,364.
［16］佟进.玫瑰蜂花粉多糖的分离纯化及理化性质分析［D］.长春:东北师范大学,2011:11-15.
［17］刘恩绪.山茶蜂花粉多糖的分离纯化和免疫活性研究［D］.长春:东北师范大学,2011:24-26.
［18］王昀,李月,唐春兰,等.红花蜂花粉多糖PBPC-Ⅱ结构分析及抗氧化活性［J］.食品工业,2019,40(5):325-330.
［19］赵昌辉,李泳财,何东,等.玉米花粉成分、功能及其应用的研究［J］.食品工业科技,2010,31(9):414-416,421.
［20］李敏.油菜花粉多糖的分离、纯化、结构鉴定及抗氧化活性的研究［D］.南昌:南昌大学,2007:58-59.
［21］Li SS,Yang G,Yan JM,et al.Polysaccharide structure and immunological relationships of RG-I pectin from the bee pollen of Nelumbo nucifera［J］.International Journal of Biological Macromolecules,2018,111:660-666.
［22］Chen F,Ran LW,Mi J,et al.Isolation,characterization and antitumor effect on DU145 cells of a main polysaccharide in pollen of Chinese wolfberry［J］.Molecules (Basel,Switzerland),2018,23(10):2430.
［23］牛靓洁.玉米种子、花粉和叶片中淀粉粒的分离纯化及其特征的比较研究［D］.郑州:河南农业大学,2020:23.
［24］李奉.荞麦蜂花粉中化学成分研究［D］.西安:西北大学,2018:30-54.
［25］李敏.银杏花的化学成分及生物活性研究［D］.北京:军事科学院,2019:12-15.
［26］巢蕾,高明亮,曹雨诞,等.水烛香蒲不同部位黄酮类化合物的动态分析［J］.广西植物,2021,41(5):831-842.
［27］吴倩,邵帅,李珊珊,等.荷花花粉的类黄酮组成［J］.植物学报,2015,50(6):721-732.
［28］王晖,耿越,徐宏楠,等.松花粉中非营养生物活性物质研究［J］.食品研究与开发,2016,37(21):208-211.
［29］李娟.荞麦蜂花粉多糖对肠道菌群的影响［D］.南昌:南昌大学,2020:12-15.
［30］唐雨,张瑜,袁久志,等.松花粉化学成分的分离与鉴定［J］.沈阳药科大学学报,2011,28(6):429432.
［31］朱高峰,陈瑞,张倚鸣,等.UPLC-Q-TOFMSE技术结合UNIFI数据库快速定性分析蒲黄化学成分［J］.广州化工,2021,49(11):79-84.
［32］裘纪莹,陈相艳,闫慧娇,等.银杏花粉黄酮组分分离纯化及其清除DPPH自由基能力［J］.农业工程学报,2018,34(10):289-295.
［33］冯绪强,曾光尧,谭健兵,等.水烛香蒲花粉镇痛活性部位化学成分研究［J］.中南药学,2012,10(3):201-204.
［34］邵丽丽,徐德平.茶蜂花粉抗氧化活性与成分［J］.天然产物研究与开发,2016,28(12):1919-1923,1988.
［35］任顺成,查磊.玉米花粉黄酮类的精制及其质谱分析［J］.河南工业大学学报(自然科学版),2010,31(4):1-4,28.
［36］徐夙侠,黄青云,林春松,等.不同育性三角梅品种之间的形态、花粉活力、造访昆虫及黄酮醇含量的比较研究［J］.植物研究,2018,38(6):860-868.
［37］Zhang H,Liu R,Lu Q.Separation and characterization of phenolamines and flavonoids from rape bee pollen,and comparison of their antioxidant activities and protective effects against oxidative stress［J］.Molecules (Basel,Switzerland),2020,25(6):E1264.
［38］郭丽梅,王盼盼.板栗花粉黄酮的精制及其质谱分析［J］.天津科技大学学报,2013,28(2):15-18.
［39］彭定利.油菜蜂花粉保肝活性成分的分离及其保肝机制初探［D］.福州:福建农林大学,2013.
［40］孙岩,郭庆兴,童群义.超声微波协同萃取法提取油菜蜂花粉中黄酮类物质［J］.食品与发酵工业,2014,40(10):238-244.
［41］邵帅.油菜及牡丹花粉抗良性前列腺增生活性成分分析［D］.南京:南京农业大学,2015.
［42］马鹏媛,代思月,张稳刚,等.伊犁地区蜂花粉中脂肪酸成分分析［J］.伊犁师范学院学报(自然科学版),2016,10(3):57-61.
［43］Villette C,Berna A,Compagnon V,et al.Plant sterol diversity in pollen from angiosperms［J］.Lipids,2015,50(8):749-760.
［44］秦玉琴,李羽晗,张旭,等.马尾松花粉的化学成分研究［J］.华西药学杂志,2018,33(1):13-16.
［45］徐元元,王悦,杨二林,等.3种蜂花粉酚类化合物组成及抗氧化活性研究［J］.西北大学学报(自然科学版),2021,51(2):303-313.
［46］Li QQ,Wang K,Marcucci MC,et al.Nutrientrich bee pollen:a treasure trove of active natural metabolites［J］.Journal of Functional Foods,2018,49:472-484.
［47］蒋欣杭,梁君玲,李建伟,等.浙贝母花及花粉中8种E族维生素的高效液相色谱—荧光分析［J］.安徽农业科学,2011,39(14):8319-8321.
［48］温力力,任露陆,郭新东,等.ICPMS法测定蜂花粉中的微量元素含量［J］.现代食品科技,2012,28(8):1076-1079.
［49］杨开,何晋浙,胡君荣,等.12种花粉中20种常量和微量元素的ICPAES法测定［J］.中国食品学报,2010,10(3):227-232.
［50］Heiling JM,Cook D,Lee ST,et al.Pollen and vegetative secondary chemistry of three pollenrewarding lupines［J］.American Journal of Botany,2019,106(5):643-655.
［51］Mohamadi M,Shamspur T,Mostafavi A.Comparison of the essential oil content and composition of the spathe,buds and pollen of Phoenix dactylifera［J］.Natural Product Research,2014,28(3):205-207.
［52］戴志乔,徐德平.油菜蜂花粉中皂苷化学成分的研究［J］.天然产物研究与开发,2013,25(3):352-354.
［53］王丹.核桃花粉化学和营养成分提取及抗氧化活性研究［D］.杨凌:西北农林科技大学,2014:14.
［54］Kim KH,Kim KH,Jeong SJ,et al.Effects of gamma irradiation on quality characteristic and microbiological safety of rape (Brassica napus) pollen［J］.Journal of the Korean Society of Food Science and Nutrition,2013,42(11):1843-1847.
［55］孙亚真,张孟琴,尤芳芳,等.牡丹花粉中4种重金属含量的测定与分析［J］.食品安全质量检测学报,2021,12(10):4174-4178.
［56］Kalayco gˇlu Z,Kaygusuz H,Dker S,et al.Characterization of Turkish honeybee pollens by principal component analysis based on their individual organic acids,sugars,minerals,and antioxidant activities［J］.LWT,2017,84:402-408.
［57］Li Q,Sun M,Wan Z,et al.Bee pollen extracts modulate serum metabolism in lipopolysaccharideinduced acute lung injury mice with antiinflammatory effects［J］.Journal of Agricultural and Food Chemistry,2019,67(28):7855-7868.
［58］陈立府,孟菲,李志良,等.油菜蜂花粉乙醇提取物对异丙肾上腺素致心肌细胞肥大的保护作用及机制研究［J］.天然产物研究与开发,2021,33(10):1741-1750.
［59］王亚莉.松花粉多糖酯化前后对小鼠结肠炎的作用及肠道菌群的研究［D］.济南:山东师范大学,2020.
［60］Shang HQ,Sha Z,Wang H,et al.Taishan Pinus massoniana pollen polysaccharide inhibits H9N2 subtype influenza virus infection both in vitro and in vivo［J］.Veterinary Microbiology,2020,248:108803.
［61］Yu CL,Wei K,Liu LP,et al.Taishan Pinus massoniana pollen polysaccharide inhibits subgroup J avian leucosis virus infection by directly blocking virus infection and improving immunity［J］.Scientific Reports,2017,7:44353.
［62］Yang XP,Guo DY,Zhang JM,et al.Characterization and antitumor activity of pollen polysaccharide［J］.International Immunopharmacology,2007,7(3):401408.
［63］左绍远,钱金栿,方淑环,等.红花蜂花粉多糖抗肿瘤活性研究［J］.医药前沿,2014(1):42-43.
［64］李北林.松花粉诱导人肝癌细胞株SKHep1细胞增殖、凋亡和自噬及其机制研究［D］.百色:右江民族医学院,2020.
［65］Tuoheti T,Rasheed HA,Meng L,et al.High hydrostatic pressure enhances the antiproliferative properties of Lotus bee pollen on the human prostate cancer PC3?cells via increased metabolites［J］.Journal of Ethnopharmacology,2020,261:113057.
［66］左绍远,林春榕,万顺康,等.云南产两种蜂花粉多糖对小鼠免疫功能的影响［J］.时珍国医国药,2017,28(1):7-9.
［67］Niu XY,Shang HQ,Chen SY,et al.Effects of Pinus massoniana pollen polysaccharides on intestinal microenvironment and colitis in mice［J］.Food & Function,2021,12(1):252-266.
［68］田应娟,朱良,尹业充.马尾松花粉总黄酮对小鼠急性酒精性肝损伤的保护作用［J］.食品科技,2010,35(8):255-258.
［69］黄爱招,李亦聪,梁超峰,等.松花粉总黄酮对小鼠化学性肝损伤保护效应探析［J］.世界中医药,2020,15(16):2373-2376.
［70］Cheng N,Ren NY,Gao H,et al.Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4induced acute liver damage in mice［J］.Food and Chemical Toxicology,2013,55:234-240.
［71］张会芳,杨亚琛,张久亮,等.油菜蜂花粉加工副产物多酚对小鼠急性肝损伤的保护作用［J］.食品安全质量检测学报,2018,9(9):2033-2040.
［72］杨悦,刘鸣畅,王凯,等.油菜蜂花粉总黄酮对体外TBHP诱导细胞氧化损伤的保护作用［J］.沈阳农业大学学报,2018,49(1):108-113.
［73］章定生,马丽萍,章琦,等.油菜花粉内酯对高脂血症大鼠降脂作用的研究［J］.蜜蜂杂志,2014,34(7):1-3.
［74］RzepeckaStojko A,Stojko J,Jasik K,et al.Antiatherogenic activity of polyphenolrich extract from bee pollen［J］.Nutrients,2017,9(12):1369.
［75］林春榕,张翠香,左绍远.荞麦蜂花粉多糖对糖尿病大鼠血糖、血脂的影响［J］.亚太传统医药,2013,9(3):7-9.
［76］钱明辉,达热卓玛,徐德平.荞麦蜂花粉多糖A的分离及其降血糖活性［J］.食品与生物技术学报,2019,38(6):80-85.
［77］Li XZ,Gong HQ,Yang SW,et al.Pectic bee pollen polysaccharide from Rosa rugosa alleviates dietinduced hepatic steatosis and insulin resistance via induction of AMPK/mTORmediated autophagy［J］.Molecules (Basel,Switzerland),2017,22(5):699.
［78］梁瑞锋,李丽红,李倩,等.松花粉饮料的加工工艺研究［J］.饮料工业,2014,17(5):11-18.
［79］闾怀中.花粉运动饮料配方研究［J］.现代农业科技,2012(17):279-280.
［80］苏博,陈凤瑞,姚沛琳,等.茶花粉韧性饼干加工工艺研究［J］.农产品加工,2020(15):18-22.
［81］不公告发明人.一种含有超微茶花粉的保健品:CN 103181510B［P］.201511-25.
［82］何德枫.一种花粉保健品及其制备方法:CN102871015B［P］.201405-07.
［83］吴丽芳,贾会领,陈雪,等.一种杜仲花粉发酵液的制备方法及其化妆品中的应用:CN112870130A［P］.2021-06-01.
［84］KurekGórecka A,Górecki M,RzepeckaStojko A,et al.Bee products in dermatology and skin care［J］.Molecules (Basel,Switzerland),2020,25(3):556.
［85］Oliveira MCD,Silva DMD,Loch FC,et al.Effect of Bee Pollen on The Immunity and Tibia Characteristics in Broilers Author(s) Loch FC I Martins PC［J］.Revista Brasileira de Ciência Avícola,2013,15(4):323-328.
［86］Fleming JC,Schmehl DR,Ellis JD.Characterizing the impact of commercial pollen substitute diets on the level of Nosema spp.in honey bees (Apis mellifera L.)［J］.PLoS One,2015,10(7):e0132014.

Memo

基金项目：甘肃省高等学校科研项目青年博士基金项目（2022QB-090）；甘肃省高等学校创新基金项目（2021A-083）；甘肃省教育厅双一流重大科研项目（GSSYLXM-05）

Last Update: 2023-05-19
Copyright @ 2020 Journal of Shaanxi University of Chinese Medicine
 Address: Middle Section of Century Avenue, Xianyang, Shaanxi Province. Post Code: 712046
Tel: 029-38185250 Fax: 029-38185250 E-mail: shxzhzs@163.com Powered by: www.editorhome.cn