[1] ZHANG Panpan LIN Jingyu ZHOU Fan XU Jinshen CHENG Youmin,.Effects of Zusanli Point Injection on Gsh-Px,EGF,Gas, Nrf2,GSTm1 Genes in Rats with Gastric Ulcer [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2023, (01): 87-93. [doi: 10.13424/j.cnki.jsctcm.2023.01.016]
Effects of Zusanli Point Injection on Gsh-Px,EGF,Gas, Nrf2,GSTm1 Genes in Rats with Gastric Ulcer
- Article number:
- 2096-1340(2023)01-0087-07
- Keywords:
- Key words:Zusanli; Electroacupuncture pretreatment; Point injection; Gastric ulcer; Gas; EGF; GSTm1
- ZTFLH:
- R245.9+5
- Code:
- A
References:
［1］程佑民,林静瑜,周凡,等.预针刺结合穴位注射对胃溃疡大鼠胃黏膜的损伤修复作用及机制探讨［J］.中国医药科学,2021,11(3):20-24.
［2］于婧妍,李静.NSAIDs相关性胃病研究进展［J］.锦州医科大学学报,2018,39(1):104-107.
［3］梁丽珠,杨良俊,樊湘珍.针灸足三里的分子生物学效应机制研究［J］.国际中医中药杂志,2020,42(11):1125-1129.
［4］向杜炼. 电针治疗对AD小鼠行为学及海马区突触相关蛋白PSD-95、SYP表达的影响［D］.北京：北京中医药大学,2019.
［5］李忠仁.实验针灸学［M］.2版.北京：中国中医药出版社，2007.
［6］刘密,雷毅军,潘思安,等.艾灸预处理对大鼠应激性胃黏膜损伤中保护因子的调节作用［J］.中华中医药学刊,2015,33(9):2068-2071.
［7］Sabiu S,Garuba T,Sunmonu T,et al.Indomethacininduced gastric ulceration in rats:protective roles of Spondias mombin and Ficus exasperata［J］.Toxicology Reports,2015,2:261-267.
［8］徐叔云，卞如濂，陈修．药理实验方法学［M］．2版．北京：人民卫生出版社，1994:1157-1160．
［9］肖韦，许昂，季晖. 胃溃疡药理模型的研究进展［J］. 药学与临床研究，2016，24（2）：145-150.
［10］Guth PH,Aures D,Paulsen G.Topical aspirin plus HCl gastric lesions in the rat:cytoprotective effect of prostaglandin,cimetidine,and probanthine［J］.Gastroenterology,1979,76(1):88-93.
［11］周华,周美启. 针灸治未病特点及作用机制研究进展［C］∥2019中国针灸学会年会暨40周年回顾论文集，湖北武汉，中国针灸学会，2019：908-911
［12］高璇,鲁海,高霄英,等.“预针刺”的现代作用机制研究进展［J］.针灸临床杂志，2020,36(8):87-90.
［13］华金双,邵素菊,王培育,等.逆针灸对过敏性哮喘大鼠血清IL-2含量及肺组织GATA-3蛋白表达的影响［J］.中医研究,2020,33(5):63-67.
［14］邓伊健,曾丽莹,曲姗姗,等.针灸治未病浅谈［J］.河南中医,2018,38(4):505-507.
［15］Dengiz GO,Odabasoglu F,Halici Z,et al.Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats［J］.Journal of Pharmacological Sciences,2007,105(1):94-102.
［16］Lanas A,GarcíaRodríguez LA,Arroyo MT,et al.Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors,traditional non-aspirin non-steroidal anti-inflammatory drugs,aspirin and combinations［J］.Gut,2006,55(12):17311738.
［17］谢慧臣,刘芬,杨强.加味四逆散对慢性心理性应激胃溃疡模型大鼠胃黏膜的保护作用［J］.中国实验方剂学杂志,2012,18(19):252256.
［18］马鸿雁.应激与非应激状态下急性酒精中毒大鼠洗胃及其效果的研究［D］.长春:吉林大学,2006.
［19］胡明曦,张栩,陈畅.细胞氧化还原调控与衰老 ［J］.生物化学与生物物理进展,2014,41(3):288-294.
［20］Tanaka J,Yuda Y.Lipid peroxidation in gastric mucosal lesions induced by indomethacin in rat［J］.Biological & Pharmaceutical Bulletin,1996,19(5):716-720.
［21］Tarnawski A,Ahluwalia A,Jones MK.Gastric cytoprotection beyond prostaglandins:cellular and molecular mechanisms of gastroprotective and ulcer healing actions of antacids［J］.Current Pharmaceutical Design,2013,19(1):126-132.
［22］Tonelli C,Chio IIC,Tuveson DA.Transcriptional regulation by Nrf2［J］.Antioxidants & Redox Signaling,2018,29(17):1727-1745.
［23］杨志国,鲍春花.谷胱甘肽转硫酶 M1 和 T1 基因多态性与肝癌易感性关系的研究［J］.中国医学工程,2020,28(10):26-28.
［24］Chang VC,Cotterchio M,Bondy SJ,et al.Iron intake,oxidative stressrelated genes and breast cancer risk［J］.International Journal of Cancer,2020,147(5):1354-1373.
［25］李会庆，周涛，温培娥，等. CYP1A1 和GSTM1与胃癌、萎缩性胃炎和胃溃疡等易感性的研究［J］,中国肿瘤，2002,11(1):25-28.
Memo
基金项目：福建省自然科学基金资助项目（2018J01853，2021J01918）；福建省卫计委中青年人才骨干项目（2018-ZQN-73）