[1] DING Chao WU Ying HUANG Xinyue SUN Yu ZHANG Huawei JIANG YiLI Yuze SONG Xiaomei ZHANG Dongdong,.Study on Chemical Constituents of Kunxianqi [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2022, (04): 32-36. [doi: 10.13424/j.cnki.jsctcm.2022.04.007]
Study on Chemical Constituents of Kunxianqi
- Article number:
- 2096-1340(2022)04-0032-05
- Keywords:
- Key words：Kunxianqi; Extraction and separation; Chemical composition; Structural identification; Fatty acid
- ZTFLH:
- R284.1?
- Code:
- A
- Abstract:
- Abstract： Objective To study the chemical constituents of Herba pachysandrae terminalis. Methods Silica gel，dextran gel，reverse phase ODS C18，semi preparative liquid chromatography and other chromatographic techniques were used for separation and purification，and 1D/2D-NMR，MS，IR and other spectroscopy techniques were used to analyze the structure. Results Nine compounds were isolated and identified as 4β-methyl-3-methylenepentane-1,2,5-triol（1），4α-methy-3-methylenepentane-1,2,5-triol（2），magnolioside（3），vanillin (4)，3,4-dihydroxybenzoic acid (5)，apocynin (6)，(E)-methyl 12-hydroxyladec-10E-enoate (7)，(E)-11-hydroxy-octadeca-12-enoic acid (8)，palmitic acid (9). Conclusion Compounds 3，6~9 were isolated from the genus Stephania for the first time.
References:
[1］宋小妹,唐志书,王薇,等.太白“七药”研究进展[J］.亚太传统医药,2009,5(2):120-123.
[2］陕西省革命委员会卫生局商业局.陕西中草药[M］.北京:科学出版社,1971.
[3］Sun Y,Ding C,Wang FR,et al.Pregnane alkaloids with BRD4 inhibitory and cytotoxic activities from Pachysandra terminalis[J］.Phytochemistry Letters,2021,45:63-67.
[4］邱明华,聂瑞麟,李忠荣.Pachysandra型生物碱的化学结构及活性筛选[J］.云南植物研究,1994,16(3):296-300.
[5］Maeda-Hagiwara M,Watanabe K,Watanabe H,et al.Effects on gastric acid secretion of a steroidal alkaloid,epipachysamine-A,extracted from Pachysandra terminalis Sieb.et Zucc[J］.Journal of Pharmacobio-Dynamics,1984,7(4):263-267.
[6］Watanabe H,Watanabe K,Shimadzu M,et al.Anti-ulcer effect of steroidal alkaloids extracted from Pachysandra terminalis[J］.Planta Medica,1986(1):56-58.
[7］Qiu MH,Nakamura N,Min BS,et al.Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra axillaris[J］.Chemistry & Biodiversity,2005,2(7):866-871.
[8］Funayama S,Noshita T,Shinoda K,et al.Cytotoxic alkaloids of Pachysandra terminalis[J］.Biological & Pharmaceutical Bulletin,2000,23(2):262-264.
[9］马胜男.转筋草紫罗兰酮型生物碱的抗肿瘤转移活性及作用机制[D］.天津:天津医科大学,2013.
[10］Jin MN,Ma SN,Zhai HY,et al.A new megastigmane alkaloid from Pachysandra terminalis with antitumor metastasis effect[J］.Chemistry of Natural Compounds,2015,51(2):311-315.
[11］Zhai HY,Zhao C,Zhang N,et al.Alkaloids from Pachysandra terminalis inhibit breast cancer invasion and have potential for development as antimetastasis therapeutic agents[J］.Journal of Natural Products,2012,75(7):1305-1311.
[12］邱明华,李德铢.黄杨科植物化学分类学初探[J］.应用与环境生物学报,2002,8(4):387-391.
[13］Zhang YY,Li YZ,Huang SQ,et al.Two new pregnane alkaloids from Pachysandra terminalis Sieb.et Zucc[J］.Natural Product Research,2020,35:1-7.
[14］Zhao H,Wang XY,Li MK,et al.A novel pregnanetype alkaloid from Pachysandra terminalis inhibits methicillinresistant Staphylococcus aureus in vitro and in vivo[J］.Phytotherapy Research:PTR,2015,29(3):373-380.
[15］杜金,朱明彦.人类非洲锥虫病的治疗研究进展[J］.现代生物医学进展,2015,15(6):1154-1159.
[16］Flittner D,Kaiser M,Mser P,et al.The alkaloid-enriched fraction of Pachysandra terminalis (Buxaceae) shows prominent activity against Trypanosoma brucei rhodesiense[J］.Molecules (Basel,Switzerland),2021,26(3):591.
[17］黄仕其,郭琳,李玉泽,等.响应面法优化捆仙绳总生物碱提取工艺[J］.陕西中医药大学学报,2021,44(5):69-73.
[18］李晨阳.转筋草中极性化学成分及生物活性研究[D］.天津:天津医科大学,2010.
[19］Kamoldinov KS,Eshbakova KA,Aisa HA.Fatty acids and coumarins of Fraxinus syriaca[J］.Chemistry of Natural Compounds,2018,54(1):166-167.
[20］郑俊霞,王乃利,陈海峰,等.翠云草中酚性成分的分离与鉴定[J］.中国药物化学杂志,2007,17(5):302-305.
[21］邵泽艳,赵娜夏,夏广萍,等.芫花醋酸乙酯部位的化学成分研究[J］.现代药物与临床,2013,28(3):278-281.
[22］赏后勤,秦民坚,吴靳荣.川射干的化学成分研究[C］.2006海峡两岸暨CSNR全国第七届天然药物资源学术研讨会论文集,2006,323-326.
[23］Zha SJ,Kuwano K,Shibahara T,et al.Algicidal hydroxylated C18 unsaturated fatty acids from the red alga Tricleocarpa jejuensis:Identification,synthesis and biological activity[J］.Fitoterapia,2020,145:104639.
[24］AbouElwafa GSE,Shaaban M,Shaaban KA,et al.Three new unsaturated fatty acids from the marine green alga Ulva fasciata delile[J］.Zeitschrift Für Naturforschung B,2009,64(10):1199-1207.
[25］吴石丽,张凡,任嘉佳,等.山楝果实的化学成分研究[J］.中草药,2022,53(3):671-677
Memo
基金项目：国家自然科学基金项目（82104368）；陕西省科技厅自然科学基础研究计划项目（2021JQ-744）；陕西中医药大学研究生创新项目（2021CX06）；陕西中医药大学学科创新团队项目（2019-YL12）