[1] LIU Yuanyuan TIAN Xuying ZHOU Yigang LI Yuze ZHANG HuaweiDENG Chong SONG Xiaomei ZHANG Dongdong WANG Wei,.Studies on Chemical Constituents of Simple Phenylpropanoidsfrom Changshengqi [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2022, (04): 27-31. [doi: 10.13424/j.cnki.jsctcm.2022.04.006]
Studies on Chemical Constituents of Simple Phenylpropanoidsfrom Changshengqi
- Article number:
- 2096-1340(2022)04-0027-05
- Keywords:
- Key words：Changshengqi; Chemical composition; Simple phenylpropanol; Cinnamic acid; Cytotoxic activity
- ZTFLH:
- R284.1
- Code:
- A
- Abstract:
- Abstract： Objective To study the chemical constituents and cytotoxic activity of Changshengqi. Methods 80% ethanol extract of Changshengqi was separated and purified by silica gel，sephadexlh-20 and RP-HPLC. The chemical structure was identified by1H-NMR,13C-NMR and mass spectrometry. The cytotoxicity of the compound was determined by MTT method. Results Nine simple phenylpropanoids were isolated and identified aslawsorosemarinol（1），cinnamic acid（2），erythro-7-methoxyguaiacylglycerol（3），erythro-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol（4），3-(4-hydroxy-3-methoxy-phenyl)-propan-1,2-diol（5），threo-1-(3-methoxy-4-ydroxy-phenyl)-propan-1,2diol（6），C-veratroylglycol（7），guaiacylglycerol（8），erythroguaiacylglycerol（9），compound 3 had cytotoxic activity against HCT116 cell line，IC50 value was (20.40±1.37) μM. Conclusion Compounds 1~5，8，9 were isolated from Schisandra chinensis for the first time. Compound 3 has cytotoxic activity.
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Memo
基金项目：国家自然科学基金项目（82174111）；陕西省科技厅重点研发计划项目（2022SF-254）；陕西中医药大学学科创新团队项目（2019-YL12）