References:

[1]Depoortere I.Taste receptors of the gut:emerging roles in health and disease[J].Gut,2014,63(1):179-190.
[2]Lee RJ,Kofonow JM,Rosen PL,et al.Bitter and sweet taste receptors regulate human upper respiratory innate immunity[J].The Journal of Clinical Investigation,2014,124(3):1393-1405.
[3]Deckmann K,Krasteva-Christ G,Rafiq A,et al.Cholinergic urethral brush cells are widespread throughout placental mammals[J].International Immunopharmacology,2015,29(1):51-56.
[4]Liu X,Gu F,Jiang L,et al.Expression of bitter taste receptor Tas2r105 in mouse kidney[J].Biochemical and Biophysical Research Communications,2015,458(4):733-738.
[5]Lund TC,Kobs AJ,Kramer A,et al.Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression[J].PLoS One,2013,8(3):e58945.
[6]Voigt A,Bojahr J,Narukawa M,et al.Transsynaptic tracing from taste receptor cells reveals local tastereceptor gene expression in gustatory Ganglia and brain[J].The Journal of Neuroscience:the Official Journal of the Society for Neuroscience,2015,35(26):9717-9729.
[7]Clark AA,Dotson CD,Elson AE,et al.TAS2R bitter taste receptors regulate thyroid function[J].FASEB Journal,2015,29(1):164-172.
[8]Devillier P,Naline E,Grassin-Delyle S.The pharmacology of bitter taste receptors and their role in human airways[J].Pharmacology & Therapeutics,2015,155:11-21.
[9]Harada Y,Koseki J,Sekine H,et al.Role of bitter taste receptors in regulating gastric accommodation in Guinea pigs[J].The Journal of Pharmacology and Experimental Therapeutics,2019,369(3):466-472.
[10]Avau B,Rotondo A,Thijs T,et al.Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation[J].Scientific Reports,2015,5:15985.
[11]Janssen S,Laermans J,Verhulst PJ,et al.Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(5):2094-2099.
[12]李俊川,姜淮芜.胆囊收缩素临床研究进展[J].现代医药卫生,2012,28(3):407-408.
[13]Yoshida R,Shin M,Yasumatsu K,et al.The role of cholecystokinin in peripheral taste signaling inmice[J].Frontiers in Physiology,2017,8:866.
[14]Grau-Bové C,Miguéns-Gómez A,González-Quilen C,et al.Modulation of food intake by differential TAS2R stimulation in rat[J].Nutrients,2020,12(12):E3784.
[15]Andreozzi P,Sarnelli G,Pesce M,et al.The bitter taste receptor agonist quinine reduces calorie intake and increases the postprandial release of cholecystokinin in healthy subjects[J].Journal of Neurogastroenterology and Motility,2015,21(4):511-519.
[16]Yamazaki T,Takahashi C,Taniguchi Y,et al.Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells[J].Biochemical and Biophysical Research Communications,2020,533(4):704-709.
[17]Jeon TI,Seo YK,Osborne TF.Gut bitter taste receptorsignalling induces ABCB1 through a mechanism involving CCK[J].The Biochemical Journal,2011,438(1):33-37.
[18]Singaram K,Gold-Smith FD,Petrov MS.Motilin:a panoply of communications between the gut,brain,and pancreas[J].Expert Review of Gastroenterology & Hepatology,2020,14(2):103-111.
[19]Deloose E,Corsetti M,Van Oudenhove L,et al.Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers[J].Neurogastroenterology & Motility,2018,30(1):e13171.
[20]张乐,白洁.胰高血糖素样肽-1在药物成瘾中的作用及机制[J].中国药理学通报,2020,36(4):488-491.
[21]Kim KS,Egan JM,Jang HJ.Denatonium induces secretion of glucagonlike peptide-1 through activation of bitter taste receptor pathways[J].Diabetologia,2014,57(10):2117-2125.
[22]Park J,Kim KS,Kim KH,et al.GLP-1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell[J].Biochemical and Biophysical Research Communications,2015,468(1/2):306-311.
[23]Pham H,Hui HX,Morvaridi S,et al.A bitter pill for type 2 diabetes?The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells[J].Biochemical and Biophysical Research Communications,2016,475(3):295-300.
[24]Huang J,Wang XL,Zhang YD.Specific types of alcoholic beverage consumption and risk of type 2 diabetes:a systematic review and meta-analysis[J].Journal of Diabetes Investigation,2017,8(1):56-68.
[25]Kok BP,Galmozzi A,Littlejohn NK,et al.Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits[J].Molecular Metabolism,2018,16:76-87.
[26]Yu YL,Liu L,Wang XT,et al.Modulation of glucagon-like peptide-1 release by berberine:in vivo and in vitro studies[J].Biochemical Pharmacology,2010,79(7):1000-1006.
[27]Yu YL,Hao G,Zhang QY,et al.Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways[J].Biochemical Pharmacology,2015,97(2):173-177.
[28]Chou WL.Therapeutic potential of targeting intestinal bitter taste receptors in diabetes associated with dyslipidemia[J].Pharmacological Research,2021,170:105693.
[29]Li JY,Xu J,Hou RF,et al.Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice[J].Biomedecine & Pharmacotherapie,2017,89:10-17.
[30]Tack J,Depoortere I,Bisschops R,et al.Influence of ghrelin on interdigestive gastrointestinal motility in humans[J].Gut,2006,55(3):327-333.
[31]Avau B,Carbone F,Tack J,et al.Ghrelin signaling in the gut,its physiological properties,and therapeutic potential[J].Neurogastroenterology & Motility,2013,25(9):720-732.
[32]Hao SZ,Sternini C,Raybould HE.Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastricadministration of bitter taste receptor ligands[J].American Journal of Physiology Regulatory,Integrative and Comparative Physiology,2008,294(1):R33-R38.
[33]Behrens M,Gu M,Fan SJ,et al.Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors[J].Chemical Biology & Drug Design,2018,91(2):422-433.
[34]Yue X,Liang J,Gu F,et al.Berberine activates bitter taste responses of enteroendocrine STC1 cells[J].Molecular and Cellular Biochemistry,2018,447(1/2):21-32.
[35]杨超.基于现代文献对中医药治疗功能性消化不良诊治规律的研究[D].南京:南京中医药大学,2018.
[36]祝捷,李宇航,王庆国,等.半夏泻心汤对功能性消化不良大鼠胃排空及血浆胃动素的影响[J].中华中医药杂志,2005,20(6):335-337.
[37]沈天华,沈洪,吴坚,等.半夏泻心汤对功能性消化不良大鼠模型血浆P物质及胃窦黏膜CGRP的影响[J].中华中医药杂志,2011,26(11):2737-2739.
[38]吴坚,张星星,沈洪.半夏泻心汤对功能性消化不良大鼠胃排空率和胃窦组织Ghrelin的影响[J].四川中医,2014,32(1):70-72.
[39]Turner A,Veysey M,Keely S,et al.Interactions between bitter taste,diet and dysbiosis:consequences for appetite and obesity[J].Nutrients,2018,10(10):E1336.
[40]Tran HTT,Herz C,Ruf P,et al.Human T2R38 bitter taste receptor expression in resting and activated lymphocytes[J].Frontiers in Immunology,2018,9:2949.

Memo

基金项目:国家自然科学基金项目(82074312)

Last Update: 2022-04-06
Copyright @ 2020 Journal of Shaanxi University of Chinese Medicine
 Address: Middle Section of Century Avenue, Xianyang, Shaanxi Province. Post Code: 712046
Tel: 029-38185250 Fax: 029-38185250 E-mail: shxzhzs@163.com Powered by: www.editorhome.cn