[1] LIU Sha ZHU Xiaona YANG Zhihong REN Xinrui WANG Xin,.Experimental Study on Tiaozhi Roumai Granule in Treatment of Hyperlipidemia Rats [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2022, (02): 67-70. [doi: 10.13424/j.cnki.jsctcm.2022.02.015]
Experimental Study on Tiaozhi Roumai Granule in Treatment of Hyperlipidemia Rats
- Article number:
- 2096-1340(2022)02-0067-05
- Keywords:
- Key words： Tiaozhi Roumai granule; Hyperlipidemia; Atherosclerosis; Experimental research; Rat
- ZTFLH:
- R285.5
- Code:
- A
- Abstract:
- Abstract： Objective To investigate the effects of Tiaozhi Roumai granule on blood lipid and neck vascular morphology in hyperlipidemia rats.Methods 72 SPF Rats were randomly divided into blank group (fed with ordinary diet),model group,low,medium and high dose groups of Tiaozhi Roumai and Western medicine simvastatin group (fed with high-fat diet).The hyperlipidemia rat model was established after 8 weeks,and the corresponding drugs were given by gavage.After gavage,the serum and neck blood vessels of rats were taken.Triglyceride (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were detected by automatic biochemical analyzer.The pathological changes of neck blood vessels were observed by HE staining.Results TC,TG and LDL-C in Tiaozhi Roumai low,medium and high groups and simvastatin group were significantly lower than those in model group (P<0.05),and HDL-C was higher than those in model group (P>0.05);The results of HE staining of cervical blood vessels showed that the smoothness,thickness and smooth muscle arrangement of cervical blood vessels in each dose group and simvastatin group were improved in varying degrees compared with the model group.Conclusion Tiaozhi Roumai granule can improve the condition of cervical plaque by regulating the process of lipid metabolism in rats,so as to play the role of anti atherosclerosis (AS).
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Memo
基金项目：咸阳市科技局项目（2018K02-87）