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[1] TIAN Xiaoming YAN Lihong JIANG Liyuan XIANG Guangfeng LI Gaofei WU Jia,.Screening and Component Analysis of Antiinflammatory and Analgesic Active Parts of Banfenghe [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2021, (05): 63-68. [doi: 10.13424/j.cnki.jsctcm.2021.05.013]

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Screening and Component Analysis of Antiinflammatory and Analgesic Active Parts of Banfenghe

Journal of Shaanxi University of Traditional Chinese Medicine[ISSN: 2096-1340/ CN: 61-1501/R] Volumes & Issues: 2021 05 pagination: 63-68 Column: Publication date: 2021-09-30

Article number:: 2096-1340(2021)05-0063-06

Author(s):: TIAN Xiaoming¹ YAN Lihong¹ JIANG Liyuan¹ XIANG Guangfeng¹ LI Gaofei1 WU Jia²; 1.Hunan Forest Botanical Garden,Changsha 410116,China;
2.School of Computer Science,Central South University,Changsha 410083,China

Keywords:: Banfenghe; Anti inflammatory; Analgesia; Active site; Component analysis

ZTFLH:: R284.3?

DOI:: 10.13424/j.cnki.jsctcm.2021.05.013

Code:: A

Abstract:: Objective This paper studies the pharmacological activity of Banfenghe from the perspective of anti-inflammatory and analgesic,screens the active parts of its anti-inflammatory and analgesic effect,and analyzes its chemical components.Methods The anti-inflammatory and analgesic activities of Banfenghe ethanol extract,petroleum ether part group,ethyl acetate part group,n-butanol part group and water-soluble part group were screened by xylene induced mouse ear swelling,acetic acid induced mouse abdominal permeability increase test,acetic acid induced mouse writhing and hot plate induced mouse pain test.LC-MS/MS analysis was used to identify the chemical components of the active parts.Results Different doses of alcohol extract of Banfenghe and ethyl acetate could significantly reduce the ear swelling induced by xylene and inhibit the increase of peritoneal capillary permeability induced by acetic acid; Intragastric administration of high-dose Banfenghe ethanol extract and ethyl acetate can significantly reduce the number of writhing induced by acetic acid and prolong the pain threshold of mice induced by hot plate method,but the analgesic effect of acetic acid writhing method is far less than that of hot plate method,which indicating that its analgesic effect may be mainly central analgesia.44 compounds were identified by LC-MS/MS.Conclusion Ethyl acetate fraction is the main active fraction of Banfenghe,which has obvious antiinflammatory and analgesic effects; The chemical constituents of ethyl acetate mainly include flavonoids,triterpenes,cycloterpenes,monoterpenes and so on.This study provides a scientific basis for the further development and utilization of medicinal resources of Banfenghe.

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Memo

基金项目：湖南省自然科学基金资助项目(2018JJ3299，2018JJ3682)；湖南省林业科技计划项目（XLK201978）

Last Update: 2021-09-23