[1] ZHANG Li LIANG Zhuofei ZHANG Huawei HUANG WenliSONG Xiaomei SONG Bei,.Effects of Total Saponins of Panax Japonicus on Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2021, (03): 75-79. [doi: 10.13424/j.cnki.jsctcm.2021.03.017]
Effects of Total Saponins of Panax Japonicus on Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats
- Article number:
- 2096-1340(2021)03-0075-05
- Keywords:
- Total Saponins of Panax japonicus; Liver fibrosis; CCl4; Lipid peroxidation; Antioxidation
- ZTFLH:
- R575. 2
- Code:
- A
- Abstract:
- Objective To investigate the protective effects of total saponins of Panax japonicus on hepatic fibrosis in- duced by carbon tetrachloride ( CCl4). Methods Liver fibrosis model was established by intraperitoneal injection of CCl4. After the experiment, liver function and liver fibrosis indexes were detected by biochemical method and ELISA method, and pathological changes of liver tissue were compared by HE and Masson staining. Results Total saponins of Panax japonicus could significantly reduce the levels of AST, ALT, LN, HA and MDA in serum, increase the levels of SOD and GSH - px, and decrease the level of HYP in liver tissue. Conclusion Total saponins of Panax japonicus can prevent liver fibrosis to some extent, and its mechanism may be related to inhibiting lipid peroxidation, reducing the gen- eration of free radicals and improving the antioxidant capacity of tissues.
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Memo
基金项目:陕西省科技厅重点研发计划项目(2018SF - 324);陕西省科技厅计划项目(202400002);陕西中医药大学 学科创新团队项目(2019 - YL12)