[1] CHEN Yi - chen, WANG Na, WANG Wen jie,.Network Pharmacology Study on Antidepressant Mechanism of Epimedium [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2021, (02): 53-60. [doi: 10.13424/j.cnki.jsctcm.2021.02.012]
Network Pharmacology Study on Antidepressant Mechanism of Epimedium
- Article number:
- 2096-1340(2021)02-0053-08
- Keywords:
- Epimedium; Depression; Network pharmacology; Target; Protein interaction
- ZTFLH:
- R282.71
- Code:
- A
- Abstract:
- Objective To study the antidepressant mechanism of Herba Epimedii by constructing the target protein in-teraction network of active ingredients and the target network of active ingredients. MethodsThe traditional Chinese medi-cine systems pharmacy (tcmsp) database was used to search for the main active components of Epimedium, and the target of each component was obtained through drugbank. The network of active component targets was constructed by Cytoscape software. The depression related targets were searched by genecards, OMIM, NCBI and other databases, and then the tar-gets of Epimedium were mapped to depression targets. String database and Cytoscape software were used to draw the target protein interaction network, and David database was used to analyze the go and KEGG pathways. Results 21 active com- ponents of Epimedium were screened, and 188 targets were involved. The results of network analysis showed that the anti-depressant effect of Epimedium mainly involved in toxic substance reaction, metal ion reaction, extracellular stimulation reaction, oxidative stress reaction and other biological processes. The antidepressant effect was exerted by regulating PI3K Akt signaling pathway, TNF signaling pathway, IL -17 signaling pathway and other signaling pathways. Conclusion The results of this study show that the antidepressant effect of Epimedium has the characteristics of multi - component, multi -target and multi - channel, which provides a new method, idea and scientific theoretical guidance for the study of antide-pressant mechanism of Epimedium.
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Memo
基金项目:陕西省科技计划自然科学基础研究项目(2017JQ8013)
通讯作者:王文杰,主管中药师 E - mail: wangwenjie8785@163. com