[1] Wang Qian, Zhang Huan, Zhang Xiaoke,.A Research Progress on Zhimu Indications for Xiaoke Rezhong and Blood Sugar - Reducing [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2020, (06): 94-97,107. [doi: 10.13424/j.cnki.jsctcm.2020.06.021]
A Research Progress on Zhimu Indications for Xiaoke Rezhong and Blood Sugar - Reducing
- Article number:
- 2096-1340(2020)06-0094-05
- Keywords:
- Xiaoke Rezhong; processed Zhimu; active ingredients and possible mechanism for reducing blood sugar; dosage; research progress
- ZTFLH:
- R282.71
- Code:
- A
- Abstract:
- Anemarrhenae ( Zhimu) ? is categorized into lung, stomach and kidney meridians with simultaneous clearing and moistening functions, which is primarily used in treating Xiaoke( diabetes in Western Medicine) and heat in the middle. Professor Zhang proposes that dry mouth and thirst which are the usual symptoms manifested in patients suffering from Xiaoke can be mitigated by anemarrhenae. This paper makes a summary of the treatment of Xiaoke diseases by anemarrhenae in history and the recent blood sugar - reducing medicine research as well as the dosage of decoction based on the literature review in the last decade. The results demonstrate that the treatment of Xiaoke and middle heat by anemarrhenae is its fundamental function and the blood sugar - reducing effect of salt - dried Zhimu is significantly better than that of liquor anemarrhenae and raw Anemarrhenae. The effective ingredient of anemarrhena is total phenols. Hopefully this paper can provide reference for the in - depth research and development of anemarrhenae.
References:
[1]钟赣生.中药学[M].3版.北京:中国中医药出版社,2012:90.
[2]森立之辑,柳长华.神农本草经:日森立之辑本[M].北京:北京科学技术出版社,2016:41,63.
[3]王菁,何灿封,陈汉锐,等.神农本草经论知母下水的本草溯源及证药浅析[J].长春中医药大学学报,2019,35(1):178-181.
[4]吴勉华,王新月.中医内科学[M].3版.北京:中国中医药出版社,2012:384.
[5]邢玉瑞,张登本.内经选读[M].北京:人民卫生出版社,2013:187.
[6](清)黄元御.长沙药解[M].北京:中国医药科技出版社,2017:114.
[7]崔玲玲,季德,袁永亮,等.知母酒炙前后指纹图谱的比较及对α-葡萄糖苷酶抑制作用的比较研究[J].海峡药学,2016,28(4):43-48.
[8]张爽,高雁,王晓婷,等.知母盐炙前后体外降血糖作用的研究[J].现代药物与临床,2016,31(12):1883-1886.
[9]王晓婷.盐知母增量成分降糖活性及药代动力学研究[D].沈阳:辽宁中医药大学,2018.
[10]张爽,曲琰,吴莹,等.盐知母降血糖活性部位作用研究[J].中国医院药学杂志,2016,36(10):791-794.
[11]陈丽,孙紫薇,宿莹,等.酒炙知母炮制工艺研究[J].人参研究,2017,29(6):51-53.
[12]笔雪艳.知母性味的物质基础研究[D].哈尔滨:黑龙江中医药大学,2014.
[13]陆兔林,宋王申,季德,等.知母盐炙工艺研究[J].中国中药杂志,2007,32(11):1098-1099.
[14]张中社.中药炮制技术[M].北京:人民卫生出版社,2012:102-104.
[15]冯菲.知母的药理作用研究进展[J].中医临床研究,2017,9(12):133,137.(下转第107页)
[16]朱建新,李旺.知母的研究进展[J].河北北方学院学报(自然科学版),2018,34(2):56-60.
[17]孙建宁,彭成.中药药理学专著[M].北京:人民卫生出版社,2017:144-145.
[18]黄芳,徐丽华,郭建明,等.知母提取物的降血糖作用[J].中国生化药物杂志,2005,25(6):332-335.
[19]蓝萍.知母中降糖活性成分的提取?结构修饰及ACE抑制活性的构效关系研究[D].重庆:西南大学,2010.
[20]刘健,喻凯,王明奎,等.知母中OfficinalisininⅠ降糖机制及中枢神经保护研究[J].中华中医药杂志,2017,32(2):782-785.
[21]张静.知母提取物改善3型糖尿病作用机制初探[D].广州:广州中医药大学,2015.
[22]张智圆.黄芪知母口服吸收有效成分分析鉴定及药理作用研究[D].哈尔滨:哈尔滨商业大学,2010.
[23]卢盛华,孙洪伟,王菊英,等.知母聚糖降糖作用及其机理研究[J].中国生化药物杂志,2003,23(2):81-83.
[24]金惠杰,邱昆成,李嘉华,等.药对知母-黄柏对胰岛素抵抗的改善作用[J].中国药理学通报,2019,35(7):1020-1024.
[25]向才红,樊讯,蒋跃文,等.基于民国中医名家临床用药的知母剂量研究[J].湖北中医杂志,2012,34(2):3-4.
[26]丁齐又,赵林华,邸莎,等.知母临床应用及其用量[J].吉林中医药,2019,39(1):32-35.
[27]宋佳,张林,陈传蓉,等.知母历代临床用量评述[J].上海中医药杂志,2014,48(10):74-78.
[28]施今墨.临床经验集[M].北京:人民卫生出版社,2005:166-179.
Memo
基金项目:国家自然科学基金(81774304)
通讯作者:张效科,教授?E-mail:zhangxiaoke12340@163.com