[1] Gao Si, Xu Pengguang, Zhou Pengjun, et al. Inhibitory Effect of Pyonex Tapping Combined with ALA – PDT Therapy on Hypertrophic Scar in Rabbit Ears [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2019, (02): 63-68. [doi: 10.13424/j.cnki.jsctcm.2019.02.020]
Inhibitory Effect of Pyonex Tapping Combined with ALA – PDT Therapy on Hypertrophic Scar in Rabbit Ears
- Article number:
- 2096-1340(2019)02-0063-06
- Keywords:
- pyonex; ALA - PDT; hypertrophic scar; matrix metalloproteinases and their tissue inhibitors; rabbit ear experiment
- ZTFLH:
- R245.3 R2 -031
- Code:
- A
- Abstract:
- Objective To study the curative effect of pyonex tapping combined with ALA - PDT therapy on hypertrophic scar in rabbit ears, and to explore its inhibitory effect on hypertrophic scar of rabbit ears. Method The experimental animals ( Japanese big ear white rabbits) were divided into normal group, negative control group, pyonex combined with ALA - PDT treatment group, ALA - PDT treatment group and PDT treatment group. The treatment group was treated with PDT intervention once a week for three times. The pyonex was pricked before each treatment. The samples were taken in January, February and March after PDT treatment for ELISA experiment and immunohistochemistry. Result The protein levels of MMP -2, MMP -9, MMP -13 and TIMP -1 in 1, 2 and 3 months after treatment with pyonex tapping combined with ALA - PDT were different between the pyonex combined with ALA - PDT group and the ALA - PDT group ( P <0. 05) . Conclusion Pyonex tapping combined with ALA - PDT can inhibit hypertrophic scar in rabbit ears.
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Memo
收稿日期：２０１８－０４－０９ 编辑：巩振东）