[1] Zhang Li, Zhao Rui,.Effect of Puerarin on Myocardial Energy Metabolism in Type 2 Diabetic Mice after Myocardial Infarction [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2019, (02): 46-49. [doi: 10.13424/j.cnki.jsctcm.2019.02.016]
Effect of Puerarin on Myocardial Energy Metabolism in Type 2 Diabetic Mice after Myocardial Infarction
- Article number:
- 2096-1340(2019)02-0046-04
- Keywords:
- diabetic mice; puerarin; diabetic mice with coronary ligation; GLUT4; CD36
- ZTFLH:
- R587.2
- Code:
- A
- Abstract:
- Objective To investigate the effect of puerarin on myocardial energy metabolism in type 2 diabetic mice after myocardial infarction. Method The mice model of diabetic myocardial infarction were established and divided into diabetic pseudomyocardial infarction group ( shame) , diabetic myocardial infarction group ( MI) , puerarin group ( MI + PUE) . The mice in group 3 were injected puerarin 1. 3 mL? kg-1 ? d -1 intraperitoneally for 4 weeks, and the survival rates of the three groups were counted. Total and membrane proteins were extracted from myocardial tissues of mice in each group. The expression of GLUT4 and CD36 proteins in myocardial cells was detected by Western blot. Result Four weeks after ligation, more than half of the MI mice died. The survival rate of MI + PUE group was significantly higher than that of MI group ( P =0. 048) ; the total GLUT4 and mGLUT4 protein increased in diabetic mice with coronary ligation; the total CD36 and mCD36 protein decreased; compared with MI group, the GLUT4 and mGLUT4 increased in MI + PUE group, while the CD36 and mGLUT36 decreased. Conclusion Puerarin improves cardiac function in diabetic mice with coronary artery ligation by regulating energy metabolism. Potential mechanism is that puerarin increases the transportand expression of GLUT4 and decreases the transport and expression of CD36.
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Memo
基金项目：陕西省中医药管理局资助项目（ＺＹＭＳ０１５）