[1] Tong Dan Hong Yan Zhan Ning Zhang Lisheng Chen Runying Hong Xia,.Effect of Clearing Lung - Heat and Relieve Panting Decoction on Eotaxin and IL -17 in Children with Respiratory Syncytial Virus Pneumonia [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2019, (01): 115-118. [doi: 10.13424/j.cnki.jsctcm.2019.01.035]
Effect of Clearing Lung - Heat and Relieve Panting Decoction on Eotaxin and IL -17 in Children with Respiratory Syncytial Virus Pneumonia
- Article number:
- 2096-1340(2019)01-0115-04
- Keywords:
- Clearing Lung - Heat and Relieve Panting Decoction; respiratory syncytial virus pneumonia; phlegm -heat lung blocking; Eotaxin; IL -17
- ZTFLH:
- R725.6
- Code:
- A
- Abstract:
- To study the effect and significance of Clearing Lung - Heat and Relieve Panting Decoction on eosinophil chemokines ( Eotaxin) and interleukin 17 ( IL -17) in serum and sputum of infants with respiratory syncytial virus pneumonia due to phlegm - heat lung blocking before and after treatment. Method: 160 children with respiratory syncytial virus pneumonia ( TCM syndrome differentiation as phlegm - heat lung blocking type of pneumonia with dyspnea and cough) were randomly divided into self - made Clearing Lung - Heat and Relieve Panting Decoction treatment group ( 68 cases) and conventional treatment control group ( 66 cases) . The changes of Eotaxin and IL -17 in serum and sputum of children with respiratory syncytial virus pneumonia before and after treatment in both groups were detected and analyzed. Result: Compared with the control group, Eotaxin and IL -17 in the treatment group decreased significantly before and after treatment ( P < 0. 01) . Conclusion: Studies have shown that the expression of Eotaxin and IL -17 in respiratory syncytial virus pneumonia is significantly increased. Clearing Lung - Heat and Relieve Panting Decoction can reduce the level of Eotaxin and IL -17 in children and the local infiltration of inflammatory cells in lung tissue to inhibit airway inflammation. It can also effectively reduce systemic inflammatory response and production of inflammatory related factors in children with respiratory syncytial virus pneumonia, and reverse the process of airway remodeling, with positive clinical significance.
References:
[1]胡亚美,江载芳,诸福棠. 实用儿科学[ M]. 7 版. 北京:人民卫生出版社,2002:1180.
[2]国家中医药管理局. 中医病证诊断疗效标准[ M]. 南京:南京大学出版社,1994:78 - 79.
[3]易阳,钟闻燕,熊建新,等. 嗜酸性粒细胞趋化因子在呼吸道合胞病毒性毛细支气管炎中的作用和意义[ J]. 临床儿科杂志,2011,29(2):136 - 138.
[4]Tanaka S, Yoshimoto T, Naka T, etal . Natural occurringIL - 17 producing T cells regulate the initial phase of neu-trophil mediated airway responses[ J]. J Immunol,2009,183(11): 7523 - 7530.
[5]Besnard AG, Togbe D, Guillou N, etal. IL - 33 - activa-ted dendritic cells are critical for allergic airway inflamma-tion[J]. Eur J Immunol, 2011, 41(6): 1675 - 1686.
[6]洪岩,陈垣,欧静琳,等,中药清肺平喘汤对呼吸道合胞病毒肺炎患儿临床及诱导痰细胞学的影响[ J]. 陕西中医,2012,33(11):1140 - 1141.
[7]李堆淑. 中药黄芩化学成分的研究进展[ J]. 江西农业学报 2013,25(8) : 51 - 54.
[8]黄楦槟,陈金水. 苏子油的药理作用研究进展[ J]. 光明中医,2015,30(9):2039 - 2041.
[9]冯志毅,杨梦,白义萍,等. 桑白皮化学拆分组分免疫调节作用研究[J]. 世界科学技术 - 中医药现代化,2014,16(9):1968 - 1973.
[10]马艳芳,刘云昊. 中西医结合治疗小儿肺炎喘嗽风热闭肺证 49 例[J]. 陕西中医药大学学报,2017,40(4):56 - 58.
[11]李海涛, 张伟. 张伟教授运用苏子降气汤治疗老年慢性喘息性支气管炎经验[ J]. 陕西中医药大学学报,2017,40(5):24 - 26.
[12]高晔珩,党力纳. 麻黄研究进展[ J]. 陕西中医学院学报,2003,26(6):60—61.
Memo
基金项目:国家名老中医药专家传承工作室建设专项经费资助项目(国中医药人教发[2014]20号);安康市科技局《安康市 2015年科学技术发展计划》项目,项目编号(2015AK04-06)