[1] Sun Lijun, Jiang Mei, Sun Yuru, et al. Experimental Study on Learning and Memory Ability and Expression of Caveolin - 1 Protein in Hippocampus of Rats with Kidney Deficiency [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2018, (06): 91-96. [doi: 10.13424/j.cnki.jsctcm.2018.06.030]
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Journal of Shaanxi University of Traditional Chinese Medicine[ISSN: 2096-1340/ CN: 61-1501/R]
Volumes & Issues:
2018 06
pagination:
91-96
Column:
Publication date:
2019-01-10
- Article number:
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2096-1340(2018)06-0091-06
- Author(s):
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Sun Lijun1; Jiang Mei2; Sun Yuru1; Li Cuijuan1; Zhang Qi1; Sun Yaoguang1
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1. Shaanxi University of Chinese Medicine,Xianyang China,712046; 2. Postgraduate School of Shaanxi University of Chinese Medicine,Xianyang China,712046
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- Keywords:
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“kidney storing will” ; constitution of kidney deficiency; learning and memory; hippocampus; Caveolin -1
- ZTFLH:
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R2 -031
- DOI:
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10.13424/j.cnki.jsctcm.2018.06.030
- Code:
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A
- Abstract:
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Objective To study the learning and memory abilities and the expression of Caveolin -1 protein in hippocampus of rats with kidney deficiency,and to explore the material basis and neurobiological mechanism of“kidney storing
will”from the perspective of synaptic plasticity. Method The rat model of congenital insufficiency and acquired intimidation of kidney deficiency was established by "cat scare rat" model. The rats were divided into four groups: model group, kidney - invigorating group,heart - tonifying group and liver - soothing group. The kidney - invigorating group,heart - tonifying group and liver - soothing group were given Liuwei Dihuang Pills,Tianwang Buxin Bolus and Xiaoyao pills re
spectively. The blank group was produced from normal pregnant rats. Morris water maze test was used to test the learning and memory abilities of rats in each group,immunohistochemical method was used to detect the positive expression ofCaveolin -1 protein in hippocampus. Result Compared with the blank group, the escape latency,the total distance and the time of first crossing the target area in the model group increased significantly,while the stay time in the target area
and the number of Caveolin -1 immunoreactive positive cells in the hippocampus decreased significantly. Compared with the model group, the escape latency, the total distance and the time of first crossing the target area in the kidney - invigorating group and heart - tonifying group increased significantly,while the stay time in the target area and the number of
Caveolin -1 immunoreactive positive cells in the hippocampus increased significantly. Compared with the heart - tonifying and liver - soothing groups, the escape latency and the time of first crossing the target area were shortened, the total distance was significantly reduced, the stay time in the target area and the expression of Caveolin - 1 in the hippocampus
were significantly increased. Conclusion The learning and memory ability of rats with kidney deficiency was degraded and
the intrinsic mechanism might be related to the decrease of Caveolin -1 protein expression in the hippocampus of rats with kidney - deficiency syndrome; Liuwei Dihuang Pills can improve the learning and memory ability of rats with kidney - deficiency syndrome by up - regulating the expression of Caveolin -1 protein; the improvement effect of heart - tonifying and liver - soothing drugs is inferior to kidney - invigorating drugs,highlighting the kidney and learning and memory. The re
lationship between them is consistent with the theory of“kidney storing will”